High-sensitivity cardiac troponin i assay to screen for acute rejection in patients with heart transplant

Circulation: Heart Failure

Volumn 7, Issue 3, 2014, Pages 463-469

  Patel, Parag C ^a   Hill, Douglas A ^b   Ayers, Colby R ^b   Lavingia, Bhavna ^b   Kaiser, Patricia ^b   Dyer, Adrian K ^b   Barnes, Aliessa P ^b   Thibodeau, Jennifer T ^b   Mishkin, Joseph D ^b   Mammen, Pradeep P A ^b   Markham, David W ^b   Stastny, Peter ^b   Ring, W Steves ^b   De Lemos, James A ^b   Drazner, Mark H ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Biopsy; Diagnosis; Graft rejection; Transplants; Troponin

Indexed keywords

TROPONIN I;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CARDIAC GRAFT REJECTION; CROSS-SECTIONAL STUDY; FEMALE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DETERMINATION; SENSITIVITY AND SPECIFICITY;

BIOPSY; DIAGNOSIS; GRAFT REJECTION; TRANSPLANTS; TROPONIN;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; MYOCARDIUM; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 84902813204     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.113.000697     Document Type: Article

References (37)

1. Gradek WQ, D'Amico C, Smith AL, Vega D, Book WM. Routine surveillance endomyocardial biopsy continues to detect significant rejection late after heart transplantation. J Heart Lung Transplant. 2001;20:497-502.
2. Stehlik J, Starling RC, Movsesian MA, Fang JC, Brown RN, Hess ML, Lewis NP, Kirklin JK; Cardiac Transplant Research Database Group. Utility of long-term surveillance endomyocardial biopsy: a multi-institutional analysis. J Heart Lung Transplant. 2006;25:1402-1409.
3. Taylor DO, Stehlik J, Edwards LB, Aurora P, Christie JD, Dobbels F, Kirk R, Kucheryavaya AY, Rahmel AO, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: Twenty-sixth Official Adult Heart Transplant Report-2009. J Heart Lung Transplant. 2009;28:1007-1022.
4. Sloan KP, Bruce CJ, Oh JK, Rihal CS. Complications of echocardiography- guided endomyocardial biopsy. J Am Soc Echocardiogr. 2009;22:324.e1-324.e4.
5. Baraldi-Junkins C, Levin HR, Kasper EK, Rayburn BK, Herskowitz A, Baughman KL. Complications of endomyocardial biopsy in heart transplant patients. J Heart Lung Transplant. 1993;12(1 Pt 1):63-67.
6. Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J, Andersen CB, Angelini A, Berry GJ, Burke MM, Demetris AJ, Hammond E, Itescu S, Marboe CC, McManus B, Reed EF, Reinsmoen NL, Rodriguez ER, Rose AG, Rose M, Suciu-Focia N, Zeevi A, Billingham ME. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710-1720.
7. Chance JJ, Segal JB, Wallerson G, Kasper E, Hruban RH, Kickler TS, Chan DW. Cardiac troponin T and C-reactive protein as markers of acute cardiac allograft rejection. Clin Chim Acta. 2001;312:31-39.
8. Hossein-Nia M, Mascaro J, McKenna WJ, Murday AJ, Holt DW. Troponin T as a non-invasive marker of cardiac allograft rejection. Lancet. 1993;341:838.
9. Mullen JC, Bentley MJ, Scherr KD, Chorney SG, Burton NI, Tymchak WJ, Koshal A, Modry DL. Troponin T and I are not reliable markers of cardiac transplant rejection. Eur J Cardiothorac Surg. 2002;22:233-237.
10. Wang CW, Steinhubl SR, Castellani WJ, Van Lente F, Miller DP, James KB, Young JB. Inability of serum myocyte death markers to predict acute cardiac allograft rejection. Transplantation. 1996;62:1938-1941.
11. Moran AM, Lipshultz SE, Rifai N, O'Brien P, Mooney H, Perry S, Perez- Atayde A, Lipsitz SR, Colan SD. Non-invasive assessment of rejection in pediatric transplant patients: serologic and echocardiographic prediction of biopsy-proven myocardial rejection. J Heart Lung Transplant. 2000;19:756-764.
12. Vazquez-Rodriguez JM, Crespo-Leiro MG, Pampin-Conde MF, Calvino-Santos R, Peteiro-Cartelle J, Gonzalez-Cuesta M, Juffe-Stein A, Castro- Beiras A, Colvino-Santos R. Cardiac troponin T is not a marker of biopsy-proven cellular rejection. J Heart Lung Transplant. 1999;18:172.
13. Wahlander H, Kjellström C, Holmgren D. Sustained elevated concentrations of cardiac troponin T during acute allograft rejection after heart transplantation in children. Transplantation. 2002;74:1130-1135.
14. Forni A, Faggian G, Luciani GB, Lamascese N, Gatti G, Dorizzi RM, Chiominto B, Mazzucco A. Correlation between troponin I serum level and acute cardiac allograft rejection: a preliminary report. Transplant Proc. 2000;32:167-168.
15. Walpoth BH, Celik B, Printzen G, Peheim E, Colombo JP, Schaffner T, Althaus U, Carrel T, Reichenspurner H, Reitz B. Assessment of troponin- T for detection of clinical cardiac rejection. Transpl Int. 1998;11(suppl 1):S502-S507.
16. Mohammed AA, Januzzi JL Jr. Clinical applications of highly sensitive troponin assays. Cardiol Rev. 2010;18:12-19.
17. Morrow DA. Clinical application of sensitive troponin assays. N Engl J Med. 2009;361:913-915.
18. Montgomery RA, Hardy MA, Jordan SC, Racusen LC, Ratner LE, Tyan DB, Zachary AA; Antibody Working Group on the Diagnosis, Reporting, and Risk Assessment for Antibody-Mediated Rejection and Desensitization Protocols. Consensus opinion from the antibody working group on the diagnosis, reporting, and risk assessment for antibody-mediated rejection and desensitization protocols. Transplantation. 2004;78:181-185.
19. Wu AH, Shea E, Lu QT, Minyard J, Bui K, Hsu JC, Agee SJ, Todd J. Short- and long-term cardiac troponin I analyte stability in plasma and serum from healthy volunteers by use of an ultrasensitive, single-molecule counting assay. Clin Chem. 2009;55:2057-2059.
20. Keller T, Zeller T, Ojeda F, Tzikas S, Lillpopp L, Sinning C, Wild P, Genth-Zotz S, Warnholtz A, Giannitsis E, Möckel M, Bickel C, Peetz D, Lackner K, Baldus S, Münzel T, Blankenberg S. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA. 2011;306:2684-2693.
21. Mills NL, Churchhouse AM, Lee KK, Anand A, Gamble D, Shah AS, Paterson E, MacLeod M, Graham C, Walker S, Denvir MA, Fox KA, Newby DE. Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome. JAMA. 2011;305:1210-1216.
22. Gupta S, Mitchell JD, Markham DW, Mammen PP, Patel PC, Kaiser P, Ring WS, DiMaio JM, Drazner MH. High incidence of cytomegalovirus disease in D+/R- heart transplant recipients shortly after completion of 3 months of valganciclovir prophylaxis. J Heart Lung Transplant. 2008;27:536-539.
23. Patel PC, Reimold SC, Araj FG, Ayers CR, Kaiser PA, Peshock RM, Yancy CW, Ring WS, Gupta S, Mishkin JD, Mammen PP, Markham DW, Drazner MH. Concentric left ventricular hypertrophy as assessed by cardiac magnetic resonance imaging and risk of death in cardiac transplant recipients. J Heart Lung Transplant. 2010;29:1369-1379.
24. Schisterman EF, Perkins NJ, Liu A, Bondell H. Optimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples. Epidemiology. 2005;16:73-81.
25. Zimmermann R, Baki S, Dengler TJ, Ring GH, Remppis A, Lange R, Hagl S, Kübler W, Katus HA. Troponin T release after heart transplantation. Br Heart J. 1993;69:395-398.
26. Labarrere CA, Nelson DR, Cox CJ, Pitts D, Kirlin P, Halbrook H. Cardiac-specific troponin I levels and risk of coronary artery disease and graft failure following heart transplantation. JAMA. 2000;284:457-464.
27. Dengler TJ, Zimmermann R, Braun K, Müller-Bardorff M, Zehelein J, Sack FU, Schnabel PA, Kübler W, Katus HA. Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation. J Am Coll Cardiol. 1998;32:405-412.
28. Muñoz-Esparza C, Garrido IP, Blanco R, Casas T, González-Cánovas C, Pastor-Pérez F, Peñafiel P, Minguela A, Valdés M, Pascual-Figal DA. Usefulness of high sensitivity troponin T assay in detecting acute allograft rejection after heart transplantation. Rev Esp Cardiol. 2011;64:1109-1113.
29. Dyer AK, Barnes AP, Fixler DE, Shah TK, Sutcliffe DL, Hashim I, Drazner MH, de Lemos JA. Use of a highly sensitive assay for cardiac troponin T and N-terminal pro-brain natriuretic peptide to diagnose acute rejection in pediatric cardiac transplant recipients. Am Heart J. 2012;163:595-600.
30. Deng MC, Eisen HJ, Mehra MR, Billingham M, Marboe CC, Berry G, Kobashigawa J, Johnson FL, Starling RC, Murali S, Pauly DF, Baron H, Wohlgemuth JG, Woodward RN, Klingler TM, Walther D, Lal PG, Rosenberg S, Hunt S; CARGO Investigators. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150-160.
31. Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Deng MC, Cappola TP, Kao A, Anderson AS, Cotts WG, Ewald GA, Baran DA, Bogaev RC, Elashoff B, Baron H, Yee J, Valantine HA; IMAGE Study Group. Geneexpression profiling for rejection surveillance after cardiac transplantation. N Engl J Med. 2010;362:1890-1900.
32. Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S, Fedson S, Fisher P, Gonzales-Stawinski G, Martinelli L, McGiffin D, Smith J, Taylor D, Meiser B, Webber S, Baran D, Carboni M, Dengler T, Feldman D, Frigerio M, Kfoury A, Kim D, Kobashigawa J, Shullo M, Stehlik J, Teuteberg J, Uber P, Zuckermann A, Hunt S, Burch M, Bhat G, Canter C, Chinnock R, Crespo-Leiro M, Delgado R, Dobbels F, Grady K, Kao W, Lamour J, Parry G, Patel J, Pini D, Towbin J, Wolfel G, Delgado D, Eisen H, Goldberg L, Hosenpud J, Johnson M, Keogh A, Lewis C, O'Connell J, Rogers J, Ross H, Russell S, Vanhaecke J; International Society of Heart and Lung Transplantation Guidelines. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29:914-956.
33. Jarcho JA. Fear of rejection-monitoring the heart-transplant recipient. N Engl J Med. 2010;362:1932-1933.
34. Wu AH, Johnson ML, Aaronson KD, Gordon D, Dyke DB, Koelling TM. Brain natriuretic peptide predicts serious cardiac allograft rejection independent of hemodynamic measurements. J Heart Lung Transplant. 2005;24:52-57.
35. Mehra MR, Uber PA, Walther D, Vesely M, Wohlgemuth JG, Prentice J, Tayama D, Billingham M. Gene expression profiles and B-type natriuretic peptide elevation in heart transplantation: more than a hemodynamic marker. Circulation. 2006;114(1 Suppl):I21-I26.
36. Knecht KR, Alexander ML, Swearingen CJ, Frazier EA. NTproBNP as a marker of rejection in pediatric heart transplant recipients. Pediatr Transplant. 2012;16:335-339.
37. Mehra MR, Parameshwar J. Gene expression profiling and cardiac allograft rejection monitoring: is IMAGE just a mirage? J Heart Lung Transplant. 2010;29:599-602.