HIV-1 cell-to-cell transmission and broadly neutralizing antibodies;Les anticorps anti-VIH-1 et la transmission virale de cellule à cellule

Medecine/Sciences

Volumn 30, Issue 5, 2014, Pages 508-510

  Malbec, Marine ^a   Mouquet, Hugo ^a   Schwartz, Olivier ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; VIRUS ANTIBODY;

ARTICLE; CELL JUNCTION; DRUG EFFECT; HELA CELL LINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; PHYSIOLOGY; VIROLOGY; VIRUS ENTRY;

ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; HELA CELLS; HIV INFECTIONS; HIV-1; HUMANS; INTERCELLULAR JUNCTIONS; VIRUS INTERNALIZATION;

EID: 84902793497     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/20143005011     Document Type: Article

References (11)

1. Euler Z, van den Kerkhof TL, van Gils MJ, et al. Longitudinal analysis of early HIV-1-specific neutralizing activity in an elite neutralizer and in five patients who developed cross-reactive neutralizing activity. J Virol 2012; 86: 2045-2055.
2. Klein F, Mouquet H, Dosenovic P, et al. Antibodies in HIV-1 vaccine development and therapy. Science 2013; 341: 1199-1204.
3. Sourisseau M, Sol-Foulon N, Porrot F, et al. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J Virol 2007; 81: 1000-1012.
4. Dale BM, Alvarez RA, Chen BK. Mechanisms of enhanced HIV spread through T-cell virological synapses. Immunol Reviews 2013; 251: 113-124.
5. Rudnicka D, Feldmann J, Porrot F, et al. Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses. J Virol 2009; 83: 6234-6246.
6. Sigal A, Kim JT, Balazs AB, et al. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 2011; 477: 95-98.
7. Malbec M, Porrot F, Rua R, et al. Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission. J Exp Med 2013; 210: 2813-2821.
8. Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503: 224-228.
9. Shingai M, Nishimura Y, Klein F, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 2013; 503: 277-280.
10. Horwitz JA, Halper-Stromberg A, Mouquet H, et al. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci USA 2013; 110: 16538-16543.
11. Peressin M, Holl V, Moog C. Les anticorps anti-VIH: multiples activités antivirales. Med Sci (Paris) 2014; 30: 69-75.