Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

Science

Volumn 344, Issue 6190, 2014, Pages 1405-1410

  Lee, Kwangkook ^a   Zhong, Xiaofen ^b   Gu, Shenyan ^a   Kruel, Anna Magdalena ^c   Dorner, Martin B ^d   Perry, Kay ^e   Rummel, Andreas ^c   Dong, Min ^b   Jin, Rongsheng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d ROBERT KOCH INSTITUTE   (Germany)

^e Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; CARBOHYDRATE; HEMAGGLUTININ; UVOMORULIN; CADHERIN; RECOMBINANT PROTEIN;

ADHESION; CHEMICAL BINDING; CRYSTAL STRUCTURE; MOLECULAR ANALYSIS; PROTEIN; TOXICITY; TOXIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL JUNCTION; CELL SURFACE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DIMERIZATION; HT 29 CELL LINE; HUMAN; INTESTINE EPITHELIUM CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; ANIMAL; CHEMISTRY; GENE SILENCING; GENETICS; MOUSE; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BOTULINUM TOXINS, TYPE A; CADHERINS; CRYSTALLOGRAPHY, X-RAY; GENE KNOCKDOWN TECHNIQUES; HEMAGGLUTININS; HT29 CELLS; HUMANS; MICE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS;

EID: 84902682720     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1253823     Document Type: Article

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