Electronic health records for intervention research: A cluster randomized trial to reduce anti biotic prescribing in primary care (eCRT study)

Annals of Family Medicine

Volumn 12, Issue 4, 2014, Pages 344-351

  Gulliford, Martin C ^a,d   van Staa, Tjeerd ^b,c   Dregan, Alex ^a   McDermott, Lisa ^e   McCann, Gerard ^b   Ashworth, Mark ^a   Charlton, Judith ^a   Little, Paul ^e   Moore, Michael V ^e   Yardley, Lucy ^e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Antibiotic; Electronic health records; Primary health care; Randomized controlled trial; Respiratory tract infection

Indexed keywords

ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; CLINICAL PRACTICE; CLUSTER ANALYSIS; CONTROLLED STUDY; DECISION SUPPORT SYSTEM; ELECTRONIC MEDICAL RECORD; FEMALE; GENERAL PRACTICE; HUMAN; MALE; MIDDLE AGED; PRIMARY HEALTH CARE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTIONS; STATISTICS AND NUMERICAL DATA; UNITED KINGDOM; UTILIZATION; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; CLUSTER ANALYSIS; DECISION SUPPORT TECHNIQUES; ELECTRONIC HEALTH RECORDS; ENGLAND; FAMILY PRACTICE; FEMALE; HUMANS; MALE; MIDDLE AGED; PRACTICE PATTERNS, PHYSICIANS'; PRIMARY HEALTH CARE; RESPIRATORY TRACT INFECTIONS; SCOTLAND; YOUNG ADULT;

EID: 84902674498     PISSN: 15441709     EISSN: 15441717     Source Type: Journal    
DOI: 10.1370/afm.1659     Document Type: Article

References (27)

1. Collier R. Rapidly rising clinical trial costs worry researchers. CMAJ. 2009;180(3):277-278.
2. Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutical trials. J Clin Epidemiol. 2009;62(5):499-505.
3. Donner A, Klar N. Pitfalls of and controversies in cluster randomization trials. Am J Public Health. 2004;94(3):416-422.
4. van Staa T P, Goldacre B, Gulliford M, et al. Pragmatic randomised trials using routine electronic health records: putting them to the test. BMJ. 2012;344:e55.
5. Vickers AJ, Scardino PT. The clinically-integrated randomized trial: proposed novel method for conducting large trials at low cost. Trials. 2009;10:14.
6. D'Avolio L, Ferguson R, Goryachev S, et al. Implementation of the Department of Veterans Affairs' frst point-of-care clinical trial. J Am Med Inform Assoc. 2012;19 (e1): e170-e176.
7. Gulliford MC, van Staa T, McDermott L, et al; electronic Cluster Randomised Trial Research Team. Cluster randomised trial in the General Practice Research Database: 1. Electronic decision support to reduce antibiotic prescribing in primary care (eCRT study). Trials. 2011;1 2:115.
8. Williams T, van Staa T, Puri S, Eaton S. Recent advances in the utility and use of the General Practice Research Database as an example of a UK Primary Care Data resource. Ther Adv Drug Saf. 2012;3(2):89-99.
9. Herrett E, Thomas SL, Schoonen WM, Smeeth L, Hall AJ. Validation and validity of diagnoses in the General Practice Research Database: a systematic review. Br J Clin Pharmacol. 2010;69(1):4-14.
10. Gulliford M, Latinovic R, Charlton J, Little P, van Staa T, Ashworth M. Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006. J Public Health (Oxf). 2009;31(4):512-520.
11. Altman DG, Bland JM. Treatment allocation by minimisation. BMJ. 2005;330(7495):843.
12. National Institute for Health and Clinical Excellence. Prescribing of Antibiotics for Self-Limiting Respiratory Tract Infections in Adults and Children in Primary Care. London, England: National Institute for Health and Clinical Excellence; 2008.
13. McDermott L, Yardley L, Little P, Ashworth M, Gulliford M; eCRT Research Team. Developing a computer delivered, theory based intervention for guideline implementation in general practice. BMC Fam Pract. 2010;11: 90.
14. Kumar S, Little P, Britten N. Why do general practitioners prescribe antibiotics for sore throat? Grounded theory interview study. BMJ. 2003;326(7381):138.
15. Hrisos S, Eccles M, Johnston M, et al. An intervention modelling experiment to change GPs' intentions to implement evidence-based practice: using theory-based interventions to promote GP management of upper respiratory tract infection without prescribing antibiotics #2. BMC Health Serv Res. 2008; 8:10.
16. Simpson SA, Wood F, Butler CC. General practitioners' perceptions of antimicrobial resistance: a qualitative study. J Antimicrob Che-mother. 2007;59(2):292-296.
17. Ranji SR, Steinman MA, Shojania KG, et al. Closing the Quality Gap: A Critical Analysis of Quality Improvement Strategies. Volume 4: Antibiotic Prescribing Behaviour. AHRQ Publication number 04(06)-0051-4. Rockville, MD: Agency for Healthcare Research and Quality; 2006.
18. Ashworth M, Charlton J, Ballard K, Latinovic R, Gulliford M. Variations in antibiotic prescribing and consultation rates for acute respiratory infection in UK general practices 1995-2000. Br J Gen Pract. 2005;55(517):603-608.
19. Hayes RJ, Bennett S. Simple sample size calculation for cluster-randomized trials. Int J Epidemiol. 1999;28(2):319-326.
20. Kerry SM, Bland JM. Unequal cluster sizes for trials in English and Welsh general practice: implications for sample size calculations. Stat Med. 2001;20(3):377-390.
21. Roshanov PS, Fernandes N, Wilczynski JM, et al. Features of effective computerised clinical decision support systems: meta-regression of 162 randomised trials. BMJ. 2013;346:f657.
22. Mair FS, May C, O'Donnell C, Finch T, Sullivan F, Murray E. Factors that promote or inhibit the implementation of e-health systems: an explanatory systematic review. Bull World Health Organ. 2012; 90(5):357-364.
23. Little P, Stuart B, Francis N, et al; GRACE consortium. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet. 2013; 382 (9899):1175-1182.
24. Gonzales R, Anderer T, McCulloch CE, et al. A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. JAMA Intern Med. 2013;173(4):267-273.
25. Ranji SR, Steinman MA, Shojania KG, Gonzales R. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care. 2008;46(8):847-862.
26. Butler CC, Simpson SA, Dunstan F, et al. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. BMJ. 2012; 344:d8173.
27. Gjelstad S, Høye S, Straand J, Brekke M, Dalen I, Lindbæk M. Improving antibiotic prescribing in acute respiratory tract infections: cluster randomised trial from Norwegian general practice (prescription peer academic detailing (Rx-PAD) study). BMJ. 2013; 347:f4403.