The use of a placebo in vaccine trials

The Lancet

Volumn 383, Issue 9935, 2014, Pages 2101-2102

  Greenwood, Brian ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HAEMOPHILUS INFLUENZAE TYPE B VACCINE; MALARIA VACCINE; PLACEBO; PNEUMOCOCCUS VACCINE; RABIES VACCINE; ROTAVIRUS VACCINE; VACCINE;

CLINICAL FEATURE; CONTROLLED CLINICAL TRIAL (TOPIC); HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; IMMUNIZATION; INFLUENZA; NOTE; PRIORITY JOURNAL; ROTAVIRUS; ROTAVIRUS INFECTION; STREPTOCOCCUS PNEUMONIAE; AFRICA; CLINICAL TRIAL (TOPIC); COMMUNITY; DRUG SAFETY; IMMUNE RESPONSE; LOWEST INCOME GROUP; PLACEBO EFFECT; PROFESSIONAL STANDARD; VACCINATION; WORLD HEALTH ORGANIZATION;

CLINICAL TRIALS AS TOPIC; DEVELOPED COUNTRIES; HUMANS; INFANT; PLACEBOS; VACCINES;

EID: 84902669921     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)60926-0     Document Type: Note

References (10)

1. WHO. Expert consultation on the use of placebos in vaccine trials. Geneva: World Health Organization, 2013.
2. Rid A, Saxena A, Baqui AH, et al. Placebo use in vaccine trials: recommendations of a WHO expert panel. Vaccine 2014; published online April 25. DOI:10.1016/j.vaccine.2014.04.022.
3. Madhi SA, Cunliffe NA, Steele D, et al. Effect of human rotavirus vaccine on severe diarrhea in African infants. N Engl J Med 2010; 362: 289-98.
4. Mulholland K, Hilton S, Adegbola R, et al. Randomised trial of Haemophilus infl uenzae type-b tetanus protein conjugate vaccine for prevention of pneumonia and meningitis in Gambian infants. Lancet 1997; 349: 1191-97.
5. Klugman KP, Madhi SA, Huebner RE, et al. A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med 2003; 349: 134-48.
6. Cutts FT, Zaman SM, Enwere G, et al. Efficacy of a nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo controlled trial. Lancet 2005; 365: 1139-46.
7. Gessner BD, Sutanto A, Linehan M, et al. Incidence of vaccine-preventable Haemophilus infl uenzae type b pneumonia and meningitis in Indonesian children: hamlet-randomised vaccine-probe trial. Lancet 2005; 365: 43-52.
8. Feikin DR, Scott JA, Gessner BD. Use of vaccines as probes to define disease burden. Lancet 2014; 383: 1762-70.
9. Agnandji ST, Lell B, Soulanoudjingar SS, for the RTS,S Clinical Trials Partnership. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med 2011; 365: 1863-75.
10. Daugla DM, Gami JP, Gamougam K, et al. Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study. Lancet 2014; 383: 40-47.