JK1 (FAM134B) represses cell migration in colon cancer: A functional study of a novel gene

Experimental and Molecular Pathology

Volumn 97, Issue 1, 2014, Pages 99-104

  Kasem, Kais ^a   Sullivan, Emily ^a   Gopalan, Vinod ^a   Salajegheh, Ali ^a   Smith, Robert A ^a   Lam, Alfred K Y ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Colon cancer; FAM134B; JK1; Migration

Indexed keywords

COLLAGEN TYPE 1; FIBRONECTIN; MESSENGER RNA; SHORT HAIRPIN RNA;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL ASSAY; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE FUNCTION; GENE SILENCING; GENETIC ANALYSIS; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; JK1 GENE; MIGRATION INHIBITION; REPRESSOR GENE; TUMOR INVASION;

COLON CANCER; FAM134B; JK1; MIGRATION;

CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; NEOPLASM PROTEINS; RNA, SMALL INTERFERING;

EID: 84902590630     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2014.06.002     Document Type: Article

References (15)

1. Akiyama S.K., Olden K., Yamada K.M. Fibronectin and integrins in invasion and metastasis. Cancer Metastasis Rev. 1995, 14:173-189.
2. Forster S.J., Talbot I.C., Critchley D.R. Laminin and fibronectin in rectal adenocarcinoma: relationship to tumour grade, stage and metastasis. Br. J. Cancer 1984, 50:51-61.
3. Gopalan V., Pillai S., Ebrahimi F., Salajegheh A., Lam T.C., Le T.K., Langsford N., Ho Y.H., Smith R.A., Lam A.K. Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance. Mol. Carcinog. 2014, 53:E36-E44.
4. Humphries M.J., Obara M., Olden K., Yamada K.M. Role of fibronectin in adhesion, migration, and metastasis. Cancer Invest. 1989, 7:373-393.
5. Hunt G. The role of laminin in cancer invasion and metastasis. Exp. Cell Biol. 1989, 57:165-176.
6. Jiang X.N., Zhou R.L., Zhang S. Effects of laminin glycopeptides on metastasis-related behaviors of cancer cells. Cell Res. 1998, 8:231-240.
7. Kasem K., Lam A. Analysis of a novel JK-1 gene expression in benign and malignant colorectal tumors. Virchows Arch. 2010, 457:165.
8. Kasem K., Gopalan V., Salajegheh A., Lu C.T., Smith R.A., Lam A.K. JK1 (FAM134B) gene and colorectal cancer: a pilot study on the gene copy number alterations and correlations with clinicopathological parameters. Exp. Mol. Pathol. 2014, 97:31-36.
9. Lam A.K., Gopalan V., Nassiri M.R., Kasim K., Dissanayake J., Tang J.C., Smith R.A. Altered JS-2 expression in colorectal cancers and its clinical pathological relevance. Mol. Oncol. 2011, 5:475-481.
10. Miles F.L., Sikes R.A. Insidious changes in stromal matrix fuel cancer progression. Mol. Cancer Res. 2014, 12:297-312.
11. Ridley A.J., Schwartz M.A., Burridge K., Firtel R.A., Ginsberg M.H., Borisy G., Parsons J.T., Horwitz A.R. Cell migration: integrating signals from front to back. Science 2003, 302:1704-1709.
12. Ritzenthaler J.D., Han S., Roman J. Stimulation of lung carcinoma cell growth by fibronectin-integrin signalling. Mol. Biosyst. 2008, 4:1160-1169.
13. Sabeh F., Shimizu-Hirota R., Weiss S.J. Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J. Cell Biol. 2009, 185:11-19.
14. Seiki M. Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer Lett. 2003, 194:1-11.
15. Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S., Tsao S.W., Lam K.Y., Beh P.S., Srivastava G., Chan A.S., Ho K.P., Tang J.C. Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma. Int. J. Mol. Med. 2007, 19:915-923.