The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: A series of 195 cases

Bone and Joint Journal

Volumn 96 B, Issue 6, 2014, Pages 829-836

  Ferguson, J Y ^a   Dudareva, M ^a   Riley, N D ^a   Stubbs, D ^a   Atkins, B L ^a   McNally, M A ^a  

^a NUFFIELD ORTHOPAEDIC CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM SULFATE; DRUG CARRIER; GLYCOPEPTIDE; MEROPENEM; TOBRAMYCIN; VANCOMYCIN;

ADULT; AGED; ARTICLE; BIODEGRADABILITY; BONE RADIOGRAPHY; CHRONIC OSTEOMYELITIS; DISEASE CLASSIFICATION; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECURRENT INFECTION; VERY ELDERLY; WOUND HEALING; WOUND HEALING IMPAIRMENT;

BONE INFECTION; OSTEOMYELITIS; ANTIBIOTIC CARRIER; CALCIUM SULPHATE; BIODEGRADABLE;

ABSORBABLE IMPLANTS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTIC PROPHYLAXIS; CALCIUM SULFATE; CHRONIC DISEASE; COHORT STUDIES; DEBRIDEMENT; DRUG CARRIERS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTRAOPERATIVE CARE; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; OSTEOMYELITIS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TOBRAMYCIN; TREATMENT OUTCOME; WOUND HEALING;

EID: 84902588840     PISSN: 20494394     EISSN: 20494408     Source Type: Journal    
DOI: 10.1302/0301-620X.96B6.32756     Document Type: Article

References (45)

1. Romanò CL, Romanò D, Logoluso N, Drago L. Bone and joint infections in adults: a comprehensive classification proposal. Eur Orthop Traumatol 2011;1:207-217.
2. Berendt A, McNally MA. Osteomyelitis. In: Warrell DA, Cox TM, Firth JD, ed. Oxford Textbook of Medicine. 5th Ed. Oxford: Oxford University Press, 2010: 3788-95.
3. Spangehl MJ, Masri BA, O'Connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg [Am] 1999;81-A:672-683.
4. Cierny G 3rd, DiPasquale D. Treatment of chronic infection. J Am Acad Orthop Surg 2006;14:S105-S110.
5. McNally M, Nagarajah K. Osteomyelitis. Orthop Trauma 2010;24:416-429.
6. Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res 2003;414:7-24.
7. McNally MA, Matthews P, Bejon P. Infection of the bones and joints. In: Williams NS, Bulstrode CJK, O'Connell PR, editors. Bailey & Love's Short Practice of Surgery. 26th Ed. Florida: Taylor & Francis group, 2013: 541-549.
8. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop Relat Res 1984;190:96-108.
9. Cho SH, Song HR, Koo KH, Jeong ST, Park YJ. Antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis. Bull Hosp Jt Dis 1997;56:140-144.
10. Evans RP, Nelson CL. Gentamicin-impregnated polymethylmethacrylate beads compared with systemic antibiotic therapy in the treatment of chronic osteomyelitis. Clin Orthop Relat Res 1993;295:37-42.
11. Walenkamp GH, Kleijn LL, de Leeuw M. Osteomyelitis treated with gentamicin-PMMA beads: 100 patients followed for 1-12 years. Acta Orthop Scand 1998;69:518-522.
12. Peltier LF. The use of plaster of paris to fill large defects in bone. Am J Surg 1959;97:311-315.
13. Coetzee AS. Regeneration of bone in the presence of calcium sulfate. Arch Otolaryngol 1980;106:405-409.
14. Sidqui M, Collin P, Vitte C, Forest N. Osteoblast adherence and resorption activity of isolated osteoclasts on calcium sulphate hemihydrate. Biomaterials 1995;16:1327-1332.
15. Turner TM, Urban RM, Gitelis S, Haggard WO, Richelsoph K. Resorption evaluation of a large bolus of calcium sulfate in a canine medullary defect. Orthopedics 2003;26:577-579.
16. Walsh WR, Morberg P, Yu Y, et al. Response of a calcium sulfate bone graft substitute in a confined cancellous defect. Clin Orthop Relat Res 2003;406:228-236.
17. Chambers HF, Sande MA. Antimicrobial Agents: The Aminoglycodsides. In: Hardman JG, Limbird, LE, eds. The Pharmacological Basis of Therapeutics. McGraw-Hill: 1996:1103-1121.
18. Beardmore AA, Brooks DE, Wenke JC, Thomas DB. Effectiveness of local antibiotic delivery with an osteoinductive and osteoconductive bone-graft substitute. J Bone Joint Surg [Am] 2005;87-A:107-112.
19. Thomas DB, Brooks DE, Bice TG, et al. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds. Clin Orthop Relat Res 2005;441:366-371.
20. Turner TM, Urban RM, Hall DJ, et al. Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets. Clin Orthop Relat Res 2005;437:97-104.
21. No authors listed. Wright Medical Technology, Inc. Osteoset® T medicated bone graft substitute technical monograph. http://www.ossano.com/ Produkter/Bensubstitut/Osteoset/Osteoset.html (accessed 12 February 2014).
22. McKee MD, Wild LM, Schemitsch EH, Waddell JP. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma 2002;16:622-627.
23. Atkins BL, Athanasou N, Deeks JJ, et al. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group. J Clin Microbiol 1998;36:2932-2939.
24. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004;351:1645-1654.
25. Sheehy SH, Atkins BA, Bejon P, et al. The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. J Infect 2010;60:338-343.
26. Blaha JD. Calcium sulfate bone-void filler. Orthopedics 1998;21:1017-1019.
27. Turner TM, Urban RM, Gitelis S, Kuo KN, Andersson GB. Radiographic and histologic assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery. One institution's experience. J Bone Joint Surg [Am] 2001;83-A:8-18.
28. Nelson CL, McLaren SG, Skinner RA, et al. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res 2002;20:643-647.
29. Chang W, Colangeli M, Colangeli S, et al. Adult osteomyelitis: debridement versus debridement plus Osteoset T pellets. Acta Orthop Belg 2007;73:238-243.
30. McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma 2010;24:483-490.
31. McNally MA, Small JO, Tofighi HG, Mollan RA. Two-stage management of chronic osteomyelitis of the long bones. The Belfast technique. J Bone Joint Surg [Br] 1993;75-B:375-380.
32. Cierny G 3rd. Chronic osteomyelitis: results of treatment. Instr Course Lect 1990;39:495-508.
33. Caesar BC, Morgan-Jones RL, Warren RE, et al. Closed double-lumen suction irrigation in the management of chronic diaphyseal osteomyelitis: long-term follow-up. J Bone Joint Surg [Br] 2009;91-B:1243-1248.
34. Robinson D, Alk D, Sandbank J, Farber R, Halperin N. Inflammatory reactions associated with a calcium sulfate bone substitute. Ann Transplant 1999;4:91-97.
35. Lee GH, Khoury JG, Bell JE, Buckwalter JA. Adverse reactions to Osteoset bone graft substitute, the incidence in a consecutive series. Iowa Orthop J 2002;22:35-38.
36. Nystrom L, Raw R, Buckwalter J, Morcuende JA. Acute intraoperative reactions during the injection of calcium sulfate bone cement for the treatment of unicameral bone cysts: a review of four cases. Iowa Orthop J 2008;28:81-84.
37. Borrelli J Jr, Prickett WD, Ricci WM. Treatment of nonunions and osseous defects with bone graft and calcium sulfate. Clin Orthop Relat Res 2003;411:245-254.
38. Kelly CM, Wilkins RM, Gitelis S, et al. The use of a surgical grade calcium sulfate as a bone graft substitute: results of a multicenter trial. Clin Orthop Relat Res 2001;382:42-50.
39. Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong) 2002;10:53-60.
40. Kwong FN, Porter RM, Griffin DR, Evans CH. Effect of tobramycin on the osteogenesis of stem cells derived from human bone marrow. J Bone Joint Surg [Br] 2009;91-B(Supp I):130-131.
41. Gitelis S, Piasecki P, Turner T, et al. Use of a calcium sulfate-based bone graft substitute for benign bone lesions. Orthopedics 2001;24:162-166.
42. Gitelis S, Virkus W, Anderson D, Piasecki P, Yao TK. Functional outcomes of bone graft substitutes for benign bone tumors. Orthopedics 2004;27:141-144.
43. Mik G, Arkader A, Manteghi A, Dormans JP. Results of a minimally invasive technique for treatment of unicameral bone cysts. Clin Orthop Relat Res 2009;467:2949-2954.
44. Urban RM, Turner TM, Hall DJ, Inoue N, Gitelis S. Increased bone formation using calcium sulfate-calcium phosphate composite graft. Clin Orthop Relat Res 2007;459:110-117.
45. Allison DC, Lindberg AW, Samimi B, Mirzayan R, Menendez LR. A comparison of mineral bone graft substitutes for bone defects. US Oncol Hematol 2011;7:38-49.