Failure of oral tyrosine supplementation to improve exercise performance in the heat

Medicine and Science in Sports and Exercise

Volumn 46, Issue 7, 2014, Pages 1417-1425

  Tumilty, Les ^a   Davison, Glen ^b   Beckmann, Manfred ^c   Thatcher, Rhys ^a  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Amino acids; catecholamines; central fatigue; mild hyperthermia; prolonged exercise

Indexed keywords

AMINO ACID; PHENYLALANINE; TYROSINE;

ADULT; BEVERAGE; BLOOD; BODY TEMPERATURE; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYCLING; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EXERCISE TOLERANCE; HEART RATE; HEAT; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SKIN TEMPERATURE; TEMPERATURE SENSE; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; AMINO ACIDS; BEVERAGES; BICYCLING; BODY TEMPERATURE; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE TOLERANCE; HEART RATE; HOT TEMPERATURE; HUMANS; MALE; PHENYLALANINE; SKIN TEMPERATURE; THERMOSENSING; TYROSINE; YOUNG ADULT;

EID: 84902549475     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000243     Document Type: Article

References (39)

1. Banderet LE, Lieberman HR. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull. 1989;22(4):759-62.
2. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol. 1986;60(6):2020-7.
3. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377-81.
4. BurgessML, Davis JM, Borg TK, Buggy J. Intracranial self-stimulation motivates treadmill running in rats. J Appl Physiol. 1991;71(4):1593-7.
5. Charles Murrin L, Morgenroth VH III, Roth RH. Dopaminergic neurons: effects of electrical stimulation on tyrosine hydroxylase. Mol Pharmacol. 1976;12(6):1070-81.
6. Cheung SS, McLellan TM. Heat acclimation, aerobic fitness, and hydration effects on tolerance during uncompensable heat stress. J Appl Physiol. 1998;84(5):1731-9.
7. Chinevere TD, Sawyer RD, Creer AR, Conlee RK, Parcell AC. Effects of L-tyrosine and carbohydrate ingestion on endurance exercise performance. J Appl Physiol. 2002;93(5):1590-7.
8. Cooper JR, Bloom FE, Roth RH. The Biochemical Basis of Neuropharmacology. London: Oxford University Press; 2003. pp. 225-70.
9. Cox B, Lee T. Further evidence for a physiological role for hypothalamic dopamine in thermoregulation in the rat. J Physiol. 1980; 300:7-17.
10. De Pauw K, Cheung SS, de Geus B, Rietjens G, Meeusen R. Guidelines to classify subject groups in sport-science research. Int J Sports Physiol Perform. 2013;8(2):111-22.
11. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974; 37(2):247-8.
12. During MJ, Acworth IN, Wurtman RJ. Dopamine release in rat striatum: physiological coupling to tyrosine supply. J Neurochem. 1989;52(5):1449-54.
13. Fernstrom JD, Faller DV. Neutral amino acids in the brain: changes in response to food ingestion. J Neurochem. 1978;30(6): 1531-8.
14. Freed CR, Yamamoto BK. Regional brain dopamine metabolism: A marker for the speed, direction, and posture of moving animals. Science. 1985;229(4708):62-5.
15. Hasegawa H, Meeusen R, Sarre S, Diltoer M, Piacentini MF, Michotte Y. Acute dopamine/norepinephrine reuptake inhibition increases brain and core temperature in rats. J Appl Physiol. 2005; 99(4):1397-401.
16. Jones AM, Poole DC. Introduction to oxygen uptake kinetics and historical development of the discipline. In: Jones AM, Poole DC, editors. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. London: Routledge; 2005. pp. 3-35.
17. Lehnert H, Reinstein DK, Strowbridge BW, Wurtman RJ. Neurochemical and behavioral consequences of acute, uncontrollable stress: effects of dietary tyrosine. Brain Res. 1984;303(2):215-23.
18. Lieberman HR, Georgelis JH, Maher TJ, Yeghiayan SK. Tyrosine prevents effects of hyperthermia on behavior and increases norepinephrine. Physiol Behav. 2005;84(1):33-8.
19. Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. 2007;92(4):575-82.
20. Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995;66(4): 313-9.
21. Nybo L. Brain temperature and exercise performance. Exp Physiol. 2012;97(3):333-9.
22. Parsons K. Human Thermal Environments. London: Taylor and Francis; 2003. pp. 81-4.
23. Perronet F, Massicote D. Table of non-protein respiratory quotient: An update. Can J Sports Sci. 1991;16:23-9.
24. Ramanathan NL. A new weighting system for mean surface temperature of the human body. J Appl Physiol. 1964;19:531-3.
25. Roelands B, Goekint M, Heyman E, et al. Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature. J Appl Physiol. 2008;105(1):206-12.
26. Roth RH, Tam SY, Ida Y, Yang JX, Deutch AY. Stress and the mesocorticolimbic dopamine systems. Ann N Y Acad Sci. 1988;537: 138-47.
27. Roth RH, Walters JR, Morgenroth VH III. Effects of alteration in impulse flow on transmitter metabolism in central dopaminergic neurons. In: Usdin E, editor. Neuropsychopharmacology of Monamines and Their Regulatory Enzymes. New York: Raven Press; 1974. pp. 369-84.
28. Sawka MN, Cheuvront SN, Kenefick RW. High skin temperature and hypohydration impair aerobic performance. Exp Physiol. 2012; 97(3):327-32.
29. St Clair Gibson A, Lambert EV, Rauch LH, et al. The role of information processing between the brain and peripheral physiological systems in pacing and perception of effort. Sports Med. 2006;36(8):705-22.
30. Strüder HK, Hollmann W, Platen P, Donike M, Gotzmann A, Weber K. Influence of paroxetine, branched-chain amino acids and tyrosine on neuroendocrine system responses and fatigue in humans. Horm Metab Res. 1998;30(4):188-94.
31. Sutton EE, Coill MR, Deuster PA. Ingestion of tyrosine: effects on endurance, muscle strength, and anaerobic performance. Int J Sport Nutr Exerc Metab. 2005;15(2):173-85.
32. Sved AF, Fernstrom JD, Wurtman RJ. Tyrosine administration reduces blood pressure and enhances brain norepinephrine release in spontaneously hypertensive rats. Proc Natl Acad Sci USA. 1979a;76(7):3511-4.
33. Tatterson AJ, Hahn AG, Martin DT, Febbraio MA. Effects of heat stress on physiological responses and exercise performance in elite cyclists. J Sci Med Sport. 2000;3(2):186-93.
34. Tumilty L, Davison G, Beckmann M, Thatcher R. Oral tyrosine supplementation improves exercise capacity in the heat. Eur J Appl Physiol. 2011;111(12):2941-50.
35. Watson P, Enever S, Page A, Stockwell J, Maughan RJ. Tyrosine supplementation does not influence the capacity to perform prolonged exercise in a warm environment. Int J Sp Nutr Exerc Metab. 2012;22(5):363-73.
36. Watson P, Hasegawa H, Roelands B, Piacentini MF, Looverie R, Meeusen R. Acute dopamine/noradrenaline reuptake inhibition enhances human exercise performance in warm, but not temperate conditions. J Physiol. 2005;565(Pt 3):873-83.
37. Welkowitz J, Cohen BH, Lea RB. Introductory Statistics for the Behavioural Sciences. 7th ed. New Jersey: Wiley; 2012. pp. 281-311.
38. Wurtman RJ, Larin F, Mostafapour S, Fernstrom JD. Brain catechol synthesis: control by brain tyrosine concentration. Science. 1974;185(146):183-4.
39. Yeghiayan SK, Luo S, Shukitt-Hale B, Lieberman HR. Tyrosine improves behavioral and neurochemical deficits caused by cold exposure. Physiol Behav. 2001;72(3):311-6.