Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis

Thrombosis Research

Volumn 134, Issue 1, 2014, Pages 63-67

  Piccin, Andrea ^a,b,c   O'Marcaigh, Aengus ^a   Mc Mahon, Corrina ^a   Murphy, Ciaran ^c   Okafor, Ikechukwu ^a   Marcheselli, Luigi ^d   Casey, William ^a   Claffey, Liam ^e   Smith, Owen Patrick ^a,c  

^a OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^b BMT Unit Hospital San Maurizio   (Italy)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^e Temple St Hospital   (Ireland)

Author keywords

amputation; Neisseria Meningitides; neutropenia; protein C; sepsis

Indexed keywords

ANTINEOPLASTIC AGENT; FIBRINOGEN; FRESH FROZEN PLASMA; OCTAPLAS; PROTEIN C;

ADOLESCENT; ARTICLE; BELOW KNEE AMPUTATION; CANCER CHEMOTHERAPY; CARDIOVASCULAR DISEASE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; INTENSIVE CARE; KIDNEY FAILURE; LANGERHANS CELL HISTIOCYTOSIS; LEUKOCYTE COUNT; LIMB AMPUTATION; LOADING DRUG DOSE; LYMPHATIC LEUKEMIA; MALE; MALIGNANT NEOPLASTIC DISEASE; NEISSERIA MENINGITIDIS; NEUROBLASTOMA; NEUTROPENIA; NEUTROPHIL COUNT; PARTIAL THROMBOPLASTIN TIME; PLASMA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTHROMBIN TIME; RETROSPECTIVE STUDY; RHABDOMYOSARCOMA; SCHOOL CHILD; SEPSIS; STREPTOCOCCUS GROUP A; SUBSTITUTION THERAPY; AMPUTATION; BLOOD; ISOLATION AND PURIFICATION; MENINGITIS, MENINGOCOCCAL; METABOLISM; MICROBIOLOGY; PROCEDURES;

ADOLESCENT; AMPUTATION; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEUKOCYTE COUNT; MALE; MENINGITIS, MENINGOCOCCAL; NEISSERIA MENINGITIDIS; PROTEIN C; RETROSPECTIVE STUDIES; SEPSIS;

EID: 84902540436     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.04.019     Document Type: Article

References (19)

1. F. Fourrier, C. Chopin, J. Goudemand, S. Hendrycx, C. Caron, and A. Rime et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies Chest 101 3 Mar 1992 816 823
2. J.A. Hazelzet, I.M. Risseeuw-Appel, R.F. Kornelisse, W.C. Hop, I. Dekker, and K.F. Joosten et al. Age-related differences in outcome and severity of DIC in children with septic shock and purpura Thromb Haemost 76 6 Dec 1996 932 938
3. A. Pettenazzo, and T. Malusa Use of protein C concentrate in critical conditions: clinical experience in pediatric patients with sepsis Minerva Anestesiol 70 5 May 2004 357 363
4. P.L. Havens, J.S. Garland, M.M. Brook, B.A. Dewitz, E.S. Stremski, and T.J. Troshynski Trends in mortality in children hospitalized with meningococcal infections, 1957 to 1987 Pediatr Infect Dis J 8 1 Jan 1989 8 11
5. T. Giraud, J.F. Dhainaut, B. Schremmer, B. Regnier, P. Desjars, and P. Loirat et al. Adult overwhelming meningococcal purpura. A study of 35 cases, 1977-1989 Arch Intern Med 151 2 Feb 1991 310 316
6. E.A. Kirsch, R.P. Barton, L. Kitchen, and B.P. Giroir Pathophysiology, treatment and outcome of meningococcemia: a review and recent experience Pediatr Infect Dis J 15 11 Nov 1996 967 978
7. M.C. Genoff, M.M. Hoffer, B. Achauer, and P. Formosa Extremity amputations in meningococcemia-induced purpura fulminans Plast Reconstr Surg 89 5 May 1992 878 881
8. M. Dreyfus, J.F. Magny, F. Bridey, H.P. Schwarz, C. Planché, and M. Dehan et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate N Engl J Med 325 22 Nov 28 1991 1565 1568
9. B. White, W. Livingstone, C. Murphy, A. Hodgson, M. Rafferty, and O.P. Smith An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia Blood 96 12 Dec 1 2000 3719 3724
10. O.P. Smith, B. White, D. Vaughan, M. Rafferty, L. Claffey, and B. Lyons et al. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans Lancet 350 9091 Nov 29 1997 1590 1593
11. E. Abraham, P.F. Laterre, R. Garg, H. Levy, D. Talwar, and B.L. Trzaskoma et al. Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death N Engl J Med 353 13 Sep 29 2005 1332 1341
12. P. Barton, A.C. Kalil, S. Nadel, B. Goldstein, R. Okhuysen-Cawley, and R.J. Brilli et al. Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis Pediatrics 113 1 Pt 1 Jan 2004 7 17
13. E.D. de Kleijn, R. de Groot, C.E. Hack, P.G. Mulder, W. Engl, and B. Moritz et al. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study Crit Care Med 31 6 Jun 2003 1839 1847
14. A.J. Martí-Carvajal, I. Solà, D. Lathyris, and A.F. Cardona Human recombinant activated protein C for severe sepsis Cochrane Database Syst Rev 14 3 Mar 2012 CD004388 10.1002/14651858.CD004388.pub5 [Review. Update in: Cochrane Database Syst Rev. 2012;12:CD004388]
15. V.M. Ranieri, B.T. Thompson, P.S. Barie, J.F. Dhainaut, I.S. Douglas, and S. Finfer et al. PROWESS-SHOCK Study Group. Drotrecogin alfa (activated) in adults with septic shock N Engl J Med 366 22 May 31 2012 2055 2064
16. http://www.ema.europa.eu/docs/en-GB/document-library/Press-release/2011/ 10/WC500116970.pdf
17. G.R. Bernard, J.L. Vincent, P.F. Laterre, S.P. LaRosa, J.F. Dhainaut, and A. Lopez-Rodriguez et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 10 Mar 8 2001 699 709
18. J.L. Vincent, G.R. Bernard, R. Beale, C. Doig, C. Putensen, and J.F. Dhainaut et al. Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment Crit Care Med 33 10 Oct 2005 2266 2277
19. P. Schellongowski, E. Bauer, U. Holzinger, T. Staudinger, M. Frass, and K. Laczika et al. Treatment of adult patients with sepsis-induced coagulopathy and purpura fulminans using a plasma-derived protein C concentrate (Ceprotin) Vox Sang 90 4 May 2006 294 301