Emerging parameters of the insulin and glucose response on the oral glucose tolerance test: Reproducibility and implications for glucose homeostasis in individuals with and without diabetes

Diabetes Research and Clinical Practice

Volumn 105, Issue 1, 2014, Pages 88-95

  Kramer, Caroline Kaercher ^a,b   Vuksan, Vladimir ^b,c   Choi, Haysook ^a   Zinman, Bernard ^a,b,d   Retnakaran, Ravi ^a,b,d  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Beta cell function; Oral glucose tolerance test; Patterns; Reproducibility; Time to glucose peak

Indexed keywords

INSULIN; INSULIN ASPART; INSULIN DETEMIR; GLUCOSE;

ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE DURATION; ENDOCRINE FUNCTION; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE RESPONSE; HUMAN; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; REPRODUCIBILITY; CELL FUNCTION; INSULIN SECRETION SENSITIVITY INDEX 2; RATING SCALE;

BETA-CELL FUNCTION; ORAL GLUCOSE TOLERANCE TEST; PATTERNS; REPRODUCIBILITY; TIME TO GLUCOSE PEAK;

ADULT; BLOOD GLUCOSE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS;

EID: 84902536393     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2014.04.023     Document Type: Article

References (37)

1. American Diabetes Association Standards of medical care in diabetes-2013. Diabetes Care 2013, 36(Suppl 1):S11-S66.
2. Mooy J.M., Grootenhuis P.A., Vries H., et al. Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study. Diabetologia 1996, 39:298-305.
3. Gordon B.A., Fraser S.F., Bird S.R., Benson A.C. Reproducibility of multiple repeated oral glucose tolerance tests. Diabetes Res Clin Pract 2011, 94:e78-e82.
4. Olefsky J.M., Reaven G.M. Insulin and glucose responses to identical oral glucose tolerance tests performed forty-eight hours apart. Diabetes 1974, 23:449-453.
5. Kosaka K., Mizuno Y., Kuzuya T. Reproducibility of the oral glucose tolerance test and the rice-meal test in mild diabetics. Diabetes 1966, 15:901-904.
6. Trenchard P.M., Jennings R.D. Diurnal variation in glucose tolerance and its reversal by lengthened fasting. BMJ 1974, 2:640-642.
7. Toeller M., Knußmann R. Reproducibility of oral glucose tolerance tests with three different loads. Diabetologia 1973, 9:102-107.
8. Abdul-Ghani M.A., Williams K., DeFronzo R., Stern M. Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose. Diabetes Care 2006, 29:1613-1618.
9. Abdul-Ghani M.A., Lyssenko V., Tuomi T., DeFronzo R.A., Groop L. Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study. Diabetes Care 2009, 32:281-286.
10. Frøslie K.F., Røislien J., Qvigstad E., Godang K., Bollerslev J., Voldner N., et al. Shape information from glucose curves: functional data analysis compared with traditional summary measures. BMC Med Res Methodol 2013, 13:6.
11. Hayashi T., Boyko E.J., Sato K.K., McNeely M.J., Leonetti D.L., Kahn S.E., et al. Patterns of insulin concentration during the OGTT predict the risk of type 2 diabetes in Japanese Americans. Diabetes Care 2013, 36:1229-1235.
12. Kim J.Y., Coletta D.K., Mandarino L.J., Shaibi G.Q. Glucose response curve and type 2 diabetes risk in Latino adolescents. Diabetes Care 2012, 35:1925-1930.
13. Nolfe G., Spreghini M.R., Sforza R.W., Morino G., Manco M. Beyond the morphology of the glucose curve following an oral glucose tolerance test in obese youth. Eur J Endocrinol 2012, 166:107-114.
14. Retnakaran R., Qi Y., Connelly P.W., Sermer M., Hanley A.J., Zinman B. Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum. Clin Endocrinol 2010, 73:476-483.
15. Tschritter O., Fritsche A., Shirkavand F., Machicao F., Haring H., Stumvoll M. Assessing the shape of the glucose curve during an oral glucose tolerance test. Diabetes Care 2003, 26:1026-1033.
16. Bartoli E., Fra G.P., Carnevale Schianca G.P. The oral glucose tolerance test (OGTT) revisited. Eur J Intern Med 2011, 22:8-12.
17. Sievenpiper J.L., Jenkins D.J., Josse R.G., Vuksan V. Dilution of the 75-g oral glucose tolerance test improves overall tolerability but not reproducibility in subjects with different body compositions. Diabetes Res Clin Pract 2001, 51:87-95.
18. Kramer C.K., Choi H., Zinman B., Retnakaran R. Determinants of reversibility of beta-cell dysfunction in response to short-term intensive insulin therapy in patients with early type 2 diabetes. Am J Physiol Endocrinol Metab 2013, 305:E1398-E1407.
19. Kramer C.K., Choi H., Zinman B., Retnakaran R. Glycemic variability in patients with early type 2 diabetes: the impact of improvement in beta-cell function. Diabetes Care 2014, 37:1116-1123.
20. Retnakaran R., Shen S., Hanley A.J., Vuksan V., Hamilton J.K., Zinman B. Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test. Obesity 2008, 16:1901-1907.
21. Retnakaran R., Qi Y., Goran M.I., Hamilton J.K. Evaluation of proposed oral disposition index measures in relation to the actual disposition index. Diabet Med 2009, 26:1198-1203.
22. Kayaniyil S., Retnakaran R., Harris S.B., Vieth R., Knight J.A., Gerstein H.C., Perkins B.A., et al. Prospective associations of vitamin D with beta-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study. Diabetes 2011, 60:2947-2953.
23. Retnakaran R., Qi Y., Harris S.B., Hanley A.J., Zinman B. Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance. Diabetes Care 2011, 34:1601-1604.
24. Zinman B., Harris S.B., Neuman J., Gerstein H.C., Retnakaran R.R., Raboud J., Qi Y., et al. Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study. Lancet 2010, 376:103-111.
25. Matsuda M., DeFronzo R.A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999, 22:1462-1470.
26. Lachin J.M. The role of measurement reliability in clinical trials. Clin Trials 2004, 1:553-566.
27. McGinn T., Wyer P.C., Newman T.B., Keitz S., Leipzig R., For G.G. Tips for learners of evidence-based medicine: 3. Measures of observer variability (kappa statistic). CMAJ 2004, 171:1369-1373.
28. Weng J., Li Y., Xu W., Shi L., Zhang Q., Zhu D., et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008, 371:1753-1760.
29. Kramer C.K., Zinman B., Retnakaran R. Short-term intensive insulin therapy in type 2 diabetes mellitus: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 2013, 1:28-34.
30. Barrett-Connor E. The oral glucose tolerance test (revisited). Eur Heart J 2002, 23:1229-1231.
31. Brohall G., Behre C.J., Hulthe J., Wikstrand J., Fagerberg B. Prevalence of diabetes and impaired glucose tolerance in 64-year-old Swedish women: experiences of using repeated oral glucose tolerance tests. Diabetes Care 2006, 29:363-367.
32. Libman I.M., Barinas-Mitchell E., Bartucci A., Robertson R., Arslanian S. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab 2008, 93:4231-4237.
33. Roman R., Zeitler P.S. Oral glucose tolerance testing in asymptomatic obese children: more questions than answers. J Clin Endocrinol Metab 2008, 93:4228-4230.
34. Caumo A., Luzi L. First-phase insulin secretion: does it exist in real life? Considerations on shape and function. Am J Physiol Endocrinol Metab 2004, 287:E371-E385.
35. Mitrakou A., Kelley D., Mokan M., Veneman T., Pangburn T., Reilly J., et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 1992, 326:22-29.
36. Baggio L.L., Drucker D.J. Biology of incretins. GLP-1 and GIP. Gastroenterology 2007, 132:2131-2157.
37. Woerle H.J., Carneiro L., Derani A., Goke B., Schirra J. The role of endogenous incretin secretion as amplifier of glucose-stimulated insulin secretion in healthy subjects and patients with type 2 diabetes. Diabetes 2012, 61:2349-2358.