Patch testing with methylchloroisothiazolinone/methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group

Contact Dermatitis

Volumn 71, Issue 1, 2014, Pages 31-34

  Bruze, Magnus ^a   Isaksson, Marléne ^a   Gruvberger, Birgitta ^a   Andersen, Klaus E ^b   Gonçalo, Margarida ^c   Goossens, An ^d   Johansen, Jeanne D ^e   Maibach, Howard I ^f   Rustemeyer, Thomas ^g   Le Coz, Christophe J ^h   White, Ian R ⁱ  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^h Cabinet de Dermatologie and Laboratoire de Dermatochimie   (France)

ⁱ ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

adverse reactions; allergic contact dermatitis; contact allergy; delayed hypersensitivity; European baseline series; MCI MI; micropipette; patch test sensitization

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; 2-METHYL-4-ISOTHIAZOLIN-3-ONE; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; ALLERGEN; KATHON 886; PRESERVATIVE; THIAZOLE DERIVATIVE;

ADULT; ARTICLE; CONTACT ALLERGY; CONTACT DERMATITIS; FEMALE; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; PATCH TEST; SKIN IRRITATION; SPAIN; SWEDEN; UNITED KINGDOM; CLINICAL TRIAL; DERMATITIS, ALLERGIC CONTACT; MULTICENTER STUDY; PROCEDURES;

ALLERGENS; DERMATITIS, ALLERGIC CONTACT; FEMALE; HUMANS; MALE; PATCH TESTS; PRESERVATIVES, PHARMACEUTICAL; THIAZOLES;

EID: 84902535679     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/cod.12241     Document Type: Article

References (10)

1. ® CG in the guinea pig. Acta Derm Venereol (Stockh) 1987: 67: 315-320.
2. ® CG. Contact Dermatitis 1987: 16: 183-188.
3. Bruze M, Dahlquist I, Gruvberger B,. Contact allergy to dichlorinated methylisothiazolinone. Contact Dermatitis 1989: 20: 219-220.
4. Hasson A, Guimaraens D, Condé-Salazar L,. Patch test sensitivity to the preservative Kathon CG in Spain. Contact Dermatitis 1990: 22: 257-261.
5. Davies E, Orton D,. Identifying the optimal patch test concentration for methylchloroisothiazolinone and methylisothiazolinone. Contact Dermatitis 2009: 60: 288-289.
6. Higgins E, Kirby B, Rogers S, et al. Methylchloroisothiazolinone and methylisothiazolinone allergic contact dermatitis and the effect of patch test concentration. Dermatitis 2013: 24: 73-76.
7. Fregert S,. Manual of Contact Dermatitis, 2nd edition: Copenhagen, Munksgaard, 1981.
8. Färm G, Wahlberg J E,. Isothiazolinones (MCI/MI): 200 ppm versus 100 ppm in the standard series. Contact Dermatitis 1991: 25: 104-107.
9. ® CG - an unusual contact sensitizer. In: Exogenous Dermatoses: Environmental Dermatitis, Menné T, Maibach HI, (eds): Boca Raton, CRC Press, Inc., 1990: pp. 283-298.
10. Isaksson M, Gruvberger B, Bruze M,. Patch testing with serial dilutions of various isothiazolinones in patients hypersensitive to methylchloroisothiazolinone/methylisothiazolinone. Contact Dermatitis 2014: 70: 269-274.