Evaluation of antifungal use in a tertiary care institution: Antifungal stewardship urgently needed

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 7, 2014, Pages 1993-1999

  Valerio, Maricela ^a,b   Rodriguez Gonzalez, Carmen Guadalupe ^a,b   Muñoz, Patricia ^a,b,c   Caliz, Betsabe ^a,b   Sanjurjo, Maria ^a,b   Bouza, Emilio ^a,b,c   Anaya, F ^d   Banares R ^d   Bustinza, A ^d   Escribano, P ^d   Fernandez Cruz A ^d   Fernandez Quero J ^d   Frias, I ^d   Gayoso, J ^d   Gijon P ^d   Guinea, J ^d   Hortal, J ^d   Martinez M C ^d   Marquez I ^d   Menarguez M C ^d   Navarro, M ^d   Padilla, B ^d   Palomo, J ^d   Pelaez T ^d   Peral, J ^d   Pinilla, B ^d   Rincon D ^d   Rodriguez M ^d   Salcedo, M ^d   Sanchez Somolinos M ^d   Verde, E ^d   Vilalta, E ^d   Zamora, E ^d   more..

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

^d Medicine Department School of Medicine Universidad Complutense de Madrid ^*

Author keywords

Candidaemia; Economic savings; Invasive aspergillosis

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; ANTIFUNGAL AGENT; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; MICAFUNGIN; POSACONAZOLE; VORICONAZOLE;

ADULT; AGED; ANTIFUNGAL SUSCEPTIBILITY; ANTIMICROBIAL THERAPY; ARTICLE; CANDIDA; CANDIDIASIS; COST CONTROL; CRITICALLY ILL PATIENT; DRUG COST; DRUG INDICATION; DRUG UTILIZATION; FEMALE; HUMAN; INTENSIVE CARE UNIT; INVASIVE ASPERGILLOSIS; LEISHMANIASIS; MAJOR CLINICAL STUDY; MALE; MOUTH INFECTION; MYCOSIS; ORAL DRUG ADMINISTRATION; PRESCRIPTION; TERTIARY HEALTH CARE; TREATMENT DURATION; VAGINITIS; ADOLESCENT; HEALTH CARE COST; HEALTH CARE POLICY; HEALTH SERVICES RESEARCH; MIDDLE AGED; STANDARDS; STATISTICS AND NUMERICAL DATA; TERTIARY CARE CENTER; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIFUNGAL AGENTS; DRUG UTILIZATION; FEMALE; HEALTH CARE COSTS; HEALTH POLICY; HEALTH SERVICES RESEARCH; HUMANS; MALE; MIDDLE AGED; TERTIARY CARE CENTERS; YOUNG ADULT;

EID: 84902489353     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku053     Document Type: Article

References (34)

1. Horn DL, Neofytos D, Anaissie EJ et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis 2009; 48: 1695-703.
2. Hennen CR. Pharmacoeconomic evaluations of antifungal therapies. Curr Med Res Opin 2009; 25: 1751-8.
3. Lopez-Medrano F, San Juan R, Lizasoain M et al. A non-compulsory stewardship programme for the management of antifungals in a university-affiliated hospital. Clin Microbiol Infect 2013; 19: 56-61.
4. Nivoix Y, Launoy A, Lutun P et al. Adherence to recommendations for the use of antifungal agents in a tertiary care hospital. J Antimicrob Chemother 2012; 67: 2506-13.
5. Sutepvarnon A, Apisarnthanarak A, Camins B et al. Inappropriate use of antifungal medications in a tertiary care center in Thailand: a prospective study. Infect Control Hosp Epidemiol 2008; 29: 370-3.
6. Ananda-Rajah MR, Slavin MA, Thursky KT. The case for antifungal stewardship. Curr Opin Infect Dis 2012; 25: 107-15.
7. Mondain V, Lieutier F, Hasseine L et al. A 6-year antifungal stewardship programme in a teaching hospital. Infection 2013; 41: 621-8.
8. Apisarnthanarak A, Yatrasert A, Mundy LM. Impact of education and an antifungal stewardship program for candidiasis at a Thai tertiary care center. Infect Control Hosp Epidemiol 2010; 31: 722-7.
9. Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts-Third Edition: Approved Standard M27-A3. CLSI, Wayne, PA, USA, 2008.
10. Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Fourth Informational Supplement M27-S4. CLSI, Wayne, PA, USA, 2012.
11. WHO Collaborating Centre for Drug Statistics Methodology. International Language for Drug Utilization Research. http://www.whocc. no/ (21 January 2014, date last accessed).
12. Almyroudis NG, Segal BH. Prevention and treatment of invasive fungal diseases in neutropenic patients. Curr Opin Infect Dis 2009; 22: 385-93.
13. Ostrosky-Zeichner L. Prophylaxis or preemptive therapy of invasive candidiasis in the intensive care unit? Crit Care Med 2004; 32: 2552-3.
14. Playford EG, Lipman J, Sorrell TC. Prophylaxis, empirical and preemptive treatment of invasive candidiasis. Curr Opin Crit Care 2010; 16: 470-4.
15. Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 503-35.
16. Walsh TJ, Anaissie EJ, Denning DW et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008; 46: 327-60.
17. Maertens J, Marchetti O, Herbrecht R et al. European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3-2009 update. Bone Marrow Transplant 2011; 46: 709-18.
18. Warren JW, Abrutyn E, Hebel JR et al. Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis 1999; 29: 745-58.
19. Lundstrom T, Sobel J. Nosocomial candiduria: a review. Clin Infect Dis 2001; 32: 1602-7.
20. Leon C, Ruiz-Santana S, Saavedra P et al. A bedside scoring system ('Candida score') for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med 2006; 34: 730-7.
21. Pavese P, Ouachi Z, Vittoz JP et al. [Adequacy of new systemic antifungal agents prescriptions in a teaching hospital]. Med Maladies Infect 2007; 37 Suppl 3: S223-8.
22. Zilberberg MD, Kollef MH, Arnold H et al. Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study. BMC Infect Dis 2010; 10: 150.
23. Arnold HM, Micek ST, Shorr AF et al. Hospital resource utilization and costs of inappropriate treatment of candidemia. Pharmacotherapy 2010; 30: 361-8.
24. Patel M, Kunz DF, Trivedi VM et al. Initial management of candidemia at an academic medical center: evaluation of the IDSA guidelines. Diagn Microbiol Infect Dis 2005; 52: 29-34.
25. Antworth A, Collins CD, Kunapuli A et al. Impact of an antimicrobial stewardship program comprehensive care bundle on management of candidemia. Pharmacotherapy 2013; 33: 137-43.
26. Raymond S, Henon T, Grenouillet F et al. [Clinical audit on the use of expensive systemic antifungals in the Besançon University Hospital]. Med Maladies Infect 2009; 39: 125-32.
27. Gutierrez F,Wall PG, Cohen J. An audit of the use of antifungal agents. J Antimicrob Chemother 1996; 37: 175-85.
28. Zarb P, Goossens H. European Surveillance of Antimicrobial Consumption (ESAC): value of a point-prevalence survey of antimicrobial use across Europe. Drugs 2011; 71: 745-55.
29. Charani E, Castro-Sanchez E, Sevdalis N et al. Understanding the determinants of antimicrobial prescribing within hospitals: the role of 'prescribing etiquette'. Clin Infect Dis 2013; 57: 188-96.
30. Clancy CJ, Yu VL, Morris AJ et al. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob Agents Chemother 2005; 49: 3171-7.
31. Pai MP, Turpin RS, Garey KW. Association of fluconazole area under the concentration-time curve/MIC and dose/MIC ratios with mortality in nonneutropenic patients with candidemia. Antimicrob Agents Chemother 2007; 51: 35-9.
32. Baddley JW, Patel M, Bhavnani SM et al. Association of fluconazole pharmacodynamics with mortality in patients with candidemia. Antimicrob Agents Chemother 2008; 52: 3022-8.
33. Rodriguez-Tudela JL, Almirante B, Rodriguez-Pardo D et al. Correlation of the MIC and dose/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia. Antimicrob Agents Chemother 2007; 51: 3599-604.
34. Dellit TH, Owens RC, McGowan JE Jr et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 2007; 44: 159-77.