Cardiovascular effects of ethanol extract of Rubus chingii hu (rosaceae) in rats: An in vivo and in vitro approach

Journal of Physiology and Pharmacology

Volumn 65, Issue 3, 2014, Pages 417-424

  Su, X H ^a   Duan, R ^a   Sun, Y Y ^a   Wen, J F ^a   Kang, D G ^b   Lee, H S ^b   Cho, K W ^a   Jin, S N ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b Wonkwang University   (South Korea)

Author keywords

5' cyclic monophosphate; Akt signaling; Endothelial nitric oxide synthase; Guanosine 3'; Nitric oxide; Potassium channels; Rubus chingii; Soluble guanylyl cyclase; Store operated calcium entry

Indexed keywords

1H 1, 2, 4 OXADIAZOLO [4, 3 A] QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; ADRENERGIC RECEPTOR; ATROPINE; DILTIAZEM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLIBENCLAMIDE; GUANYLATE CYCLASE; MUSCARINIC RECEPTOR; N (G) NITROARGININE METHYL ESTER; PLANT EXTRACT; PROPRANOLOL; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; RUBUS CHINGII EXTRACT; TETRYLAMMONIUM; THAPSIGARGIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; WORTMANNIN; ALCOHOL; HERBACEOUS AGENT;

ANIMAL BEHAVIOR; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CALCIUM DEPLETION; CALCIUM SIGNALING; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG EFFECT; FORCE TRANSDUCER; HEART RATE; MALE; NONHUMAN; PRESSURE TRANSDUCER; RAT; RUBUS; RUBUS CHINGII; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; VASCULAR RING; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FRUIT; ISOLATION AND PURIFICATION; ROSACEAE; SPRAGUE DAWLEY RAT;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ETHANOL; FRUIT; HEART RATE; MALE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; ROSACEAE; VASODILATION;

EID: 84902467243     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Rosamond W, Flegal K, Furie K, et al. American Heart Association. Heart disease and stroke statistics - 2008 update. a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008; 117: 125-146.
2. Lefkowitz RJ, Willerson JT. Prospects for cardiovascular research. JAMA 2001; 285: 581-587.
3. Liu H, Chen YF, Li F, Zhang HY. Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development. J Asian Nat Prod Res 2013; 15: 94-110.
4. Biala A, Finckenberg P, Korpi A, et al. Cardiovascular effects of the combination of levosimendanand valsartan in hypertensive Dahl/Rapp rats. J Physiol Pharmacol 2011; 62: 275-285.
5. Del Rio D, Costa LG, Lean ME, Crozier A. Polyphenols and health: what compounds are involved? Nutr Metab Cardiovasc 2010; 20: 1-6.
6. Hajhashemi V, Ghannadi A, Peseshkian SK. Antinociceptive and anti-inflammatory effects of Satureya hortensis L. extracts and essential oil. J Ethnopharmacol 2002; 82: 83-87.
7. Jakala P, Pere E, Lehtinen R, Turpeinen A, Korpela R, Vapataalo H. Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats. J Physiol Pharmacol 2009; 60: 11-20.
8. Patel AV, Rojas-Vera J, Dacke CG. Therapeutic constituents and actions of Rubus species. Curr Med Chem 2004; 11: 1501-1512.
9. Halliwell B. Antioxidants and human diseases: a general introduction. Nutr Rev 1997; 55: S44-S52.
10. Hadi SM, Asad SF, Singh S, Ahmad A. Putative mechanism for anticancer and apoptosis-inducing properties of plant derived polyphenolic compounds. IUBMB Life 2000; 50: 167-177.
11. Guo QL, Gao J Y, Yang JS. Analysis of bioactive triterpenes from Rubus chingii by cyclodextrin-modified capillary electrophoresis. Chromatographia 2005; 62: 145-150.
12. Guo QL, Yang JS. Studies on chemical constituents in fruit of Rubus chingii. [in Chinese]. Zhongguo Zhong Yao Za Zhi 2005; 30: 198-200.
13. Guo QL, Yang JS, Liu JX. Studies on chemical constituents in fruit of Rubus chingii. [in Chinese]. Zhongguo Zhong Yao Za Zhi 2007; 42: 1141-1143.
14. Rocabado GO, Bedoya LM, Abad MJ, Bermejo P. Rubus-a review of its phytochemical and pharmacological profile. Nat Prod Commun 2008; 3: 423-436.
15. Liu JS, Wang G, Wang GK. Study on chemical constituents of Rubus chingii. [in Chinese]. Zhongguo Zhong Yao Za Zhi 2008; 15: 197-199.
16. You MT, Li YK, Guo ML. Study on chemical constituents of methylene dichloride extract of Rubus chingii. Acad J Second Mil Med Univ 2009; 30: 1199-1202.
17. Choi J, Lee KT, Ha J, et al. Antinociceptive and antiinflammatory effects of Niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus. Biol Pharm Bull 2003; 26: 1436-1441.
18. Wang YC, Li F, Tao L. Inhibiting effect of Rubus chingii Hu extract on matrix metalloprotease in vitro. Chin J Clin Pharmacol 2011; 27: 291-292.
19. Ding HY. Extracts and constituents of Rubus chingii with 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity. Int J Mol Sci 2011; 12: 3941-3949.
20. Xie XM, Pang XB. Effects of Rubi Fructus extract on glucose and blood lipid metabolisms and protective effects on liver in type 2 diabetic rats. Chin Tradit Pat Med 2013; 35: 460-465.
21. Tirapelli CR, Legros E, Brochu I, et al. Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats. Br J Pharmacol 2008; 154: 971-981.
22. Jin SN, Wen JF, Wang TT, Kang DG, Lee HS, Cho KW. Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta. J Ethnopharmacol 2012; 142: 188-193.
23. Torok J. Histamine-induced relaxation in pulmonary artery of normotensive and hypertensive rats: relative contribution of prostanoids, nitric oxide and hyperpolarization. Physiol Res 2000; 49: 107-114.
24. Luksha L, Agewall S, Kublickiene K. Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease. Atherosclerosis 2009; 202: 330-344.
25. Bian K, Doursout MF, Murad F. Vascular system: role of nitric oxide in cardiovascular diseases. J Clin Hypertens (Greenwich) 2008; 10: 304-310.
26. Bredt DS, Ferris CD, Snyder SH. Nitric oxide synthase regulatory sites: phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase, identification of flavin and calmodulin binding sites. J Biol Chem 1992; 267: 10976-10981.
27. Buchwalow IB, Podzuweit T, Samoilova VE, Wellner M, Haller H, Grote S, Aleth S, Boecker W, Schmitz W, Neumann J. An in situ evidence for autocrine function of NO in the vasculature. Nitric Oxide 2004; 10: 203-212.
28. Cacanyiova S, Dovinova I, Kristek F. The role of oxidative stress in acetylcholine-induced relaxation of endothelium-denuded arteries. J Physiol Pharmacol 2013; 64: 241-247.
29. Murphy ME, Brayden JE. Apamin-sensitive K+ channels mediate an endothelium-dependent hyperpolarization in rabbit mesenteric arteries. J Physiol 1995; 489: 723-734.
30. Loeb AL, Izzo NJ, Jr., Johnson RM, Garrison JC, Peach MJ. Endothelium-derived relaxing factor release associated with increased endothelial cell inositoltrisphosphate and intracellular calcium. Am J Cardiol 1988; 62: 36G-40G.
31. Berridge MJ. Cell signalling. A tale of two messengers. Nature 1993; 365: 388-389.
32. Parekh AB, Putney JW, Jr. Store-operated calcium channels. Physiol Res 2005; 85: 757-810.
33. Dolor RJ, Hurwitz LM, Mirza Z, Strauss HC, Whorton AR. Regulation of extracellular calcium entry in endothelial cells: role of intracellular pool. Am J Physiol 1992; 262: C171-C181.
34. Lin S, Fagan KA, Li KX, Shaul, PW, Cooper DMF, Rodman DM. Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry. J Biol Chem 2000; 275: 17979-17985.
35. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AN. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-605.
36. Fluton D, Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597-601.
37. Fleming I, Busse R. Signal transduction of eNOS activation. Cardiovasc Res 1999; 43: 532-541.
38. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268: C799-C822.
39. Ledoux J, Werner ME, Brayden JE, Nelson MT. Calcium activated potassium channels and the regulation of vascular tone. Physiology 2006; 21: 69-78.