Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

Cell Host and Microbe

Volumn 15, Issue 6, 2014, Pages 768-778

  Maekawa, Tomoki ^a   Krauss, Jennifer L ^b   Abe, Toshiharu ^a   Jotwani, Ravi ^b   Triantafilou, Martha ^c   Triantafilou, Kathy ^c   Hashim, Ahmed ^d   Hoch, Shifra ^e   Curtis, Michael A ^d   Nussbaum, Gabriel ^e   Lambris, John D ^f   Hajishengallis, George ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR C5AR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE A; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; C5AR1 PROTEIN, HUMAN; COMPLEMENT; COMPLEMENT COMPONENT C5A RECEPTOR; MYD88 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; TLR2 PROTEIN, HUMAN; TLR2 PROTEIN, MOUSE;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOKINE RESPONSE; DYSBIOSIS; FUSOBACTERIUM NUCLEATUM; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; MACROPHAGE; MOUSE; NONHUMAN; PATTERN RECOGNITION; PHAGOCYTOSIS; PHENOTYPE; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; BACTEROIDACEAE INFECTION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTANT MOUSE STRAIN; NEUTROPHIL; PATHOGENICITY; PERIODONTITIS;

ANIMALS; BACTEROIDACEAE INFECTIONS; COMPLEMENT SYSTEM PROTEINS; DYSBIOSIS; HOST-PATHOGEN INTERACTIONS; MICE; MICE, MUTANT STRAINS; MYELOID DIFFERENTIATION FACTOR 88; NEUTROPHILS; PERIODONTITIS; PHAGOCYTOSIS; PHOSPHATIDYLINOSITOL 3-KINASES; PORPHYROMONAS GINGIVALIS; RECEPTOR, ANAPHYLATOXIN C5A; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

EID: 84902458366     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2014.05.012     Document Type: Article

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