Understanding anti-leukemia responses to donor lymphocyte infusion

OncoImmunology

Volumn 3, Issue 3, 2014, Pages

  Bachireddy, Pavan ^a,b   Wu, Catherine J ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

CML; Donor lymphocyte infusion; Stem cell transplantation; T cell exhaustion; Tumor infiltrating lymphocytes

Indexed keywords

ADOPTIVE TRANSFER; ANTIBODY SPECIFICITY; ARTICLE; BONE MARROW APLASIA; CANCER IMMUNIZATION; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC MYELOID LEUKEMIA; DONOR LYMPHOCYTE INFUSION; GENETIC TRANSCRIPTION; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMORAL IMMUNITY; LEUKEMIA RELAPSE; LYMPHOCYTE DEPLETION; LYMPHOCYTIC INFILTRATION; NONHUMAN; TUMOR IMMUNITY;

EID: 84902436421     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.28187     Document Type: Article

References (10)

1. Wu CJ, Ritz J. Induction of tumor immunity following allogeneic stem cell transplantation. Adv Immunol 2006; 90:133-73; PMID:16730263; http://dx.doi.org/10.1016/S0065-2776(06)90004-2
2. Kolb HJ, Mittermüller J, Clemm C, Holler E, Ledderose G, Brehm G, Heim M, Wilmanns W. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 1990; 76:2462-5; PMID:2265242
3. Roddie C, Peggs KS. Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation. Expert Opin Biol Ther 2011; 11:473-87; PMID:21269237; http://dx.doi.org/10.1517/147125 98.2011.554811
4. Soiffer RJ, Alyea EP, Hochberg E, Wu C, Canning C, Parikh B, Zahrieh D, Webb I, Antin J, Ritz J. Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion. Biol Blood Marrow Transplant 2002; 8:625-32; PMID:12463482; http://dx.doi.org/10.1053/bbmt.2002.v8.abbmt080625
5. Zhang W, Choi J, Zeng W, Rogers SA, Alyea EP, Rheinwald JG, Canning CM, Brusic V, Sasada T, Reinherz EL, et al. Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion. Clin Cancer Res 2010; 16:2729-39; PMID:20460482; http://dx.doi.org/10.1158/1078-0432.CCR-10-0415
6. Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, et al. Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acidimmunoglobulin complexes in humans. J Clin Invest 2011; 121:1574-84; PMID:21403403; http://dx.doi. org/10.1172/JCI44581
7. Bachireddy P, Hainz U, Rooney M, Pozdnyakova O, Aldridge J, Zhang W, Liao X, Hodi FS, O'Connell K, Haining WN, et al. Reversal of in situ T-cell exhaustion during effective human antileukemia responses to donor lymphocyte infusion. Blood 2014; 123:1412-21; PMID:24357730; http://dx.doi. org/10.1182/blood-2013-08-523001
8. Schmid C, Labopin M, Nagler A, Bornhäuser M, Finke J, Fassas A, Volin L, Gürman G, Maertens J, Bordigoni P, et al.; EBMT Acute Leukemia Working Party. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stemcell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J Clin Oncol 2007; 25:4938-45; PMID:17909197; http://dx.doi. org/10.1200/JCO.2007.11.6053
9. Wherry EJ. T cell exhaustion. Nat Immunol 2011; 12:492-9; PMID:21739672; http://dx.doi. org/10.1038/ni.2035
10. Burkhardt UE, Hainz U, Stevenson K, Goldstein NR, Pasek M, Naito M, Wu D, Ho VT, Alonso A, Hammond NN, et al. Autologous CLL cell vaccination early after transplant induces leukemiaspecific T cells. J Clin Invest 2013; 123:3756-65; PMID:23912587; http://dx.doi.org/10.1172/JCI69098