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Volumn 15, Issue 2, 2014, Pages 238-247

The role of allogeneic stem cell transplantation in Hodgkin's lymphoma

Author keywords

Allogeneic stem cell transplantation; Graft versus Hodgkin's lymphoma effect; Hodgkin's lymphoma; Reduced intensity conditioning regimen; Refractory disease

Indexed keywords

BRENTUXIMAB VEDOTIN; ANTIBODY CONJUGATE; CAC10-VCMMAE; HLA ANTIGEN; OLIGOPEPTIDE; VEDOTIN;

EID: 84902362699     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-014-0287-3     Document Type: Article
Times cited : (13)

References (26)
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    • Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: An analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
    • A total of 168 patients with Hodgkin's lymphoma undergoing a first allogeneic stem cell transplantation [reduced intensity conditioning (RIC), n=89; myeloablative conditioning, n=79] between January 1997 and December 2001 were compared. Nonrelapse mortality was significantly decreased in the RIC group, overall survival was better in the RIC group, and there was a trend for better progression-free survival in the RIC group. The development of chronic graft-versus- host disease significantly decreased the incidence of relapse, which translated into a trend for a better progres-sion- free survival
    • •• Sureda A, Robinson S, Canals C, et al. Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: an analysis from the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. J Clin Oncol. 2008;26:455-62. A total of 168 patients with Hodgkin's lymphoma undergoing a first allogeneic stem cell transplantation [reduced intensity conditioning (RIC), n=89; myeloablative conditioning, n=79] between January 1997 and December 2001 were compared. Nonrelapse mortality was significantly decreased in the RIC group, overall survival was better in the RIC group, and there was a trend for better progression-free survival in the RIC group. The development of chronic graft-versus- host disease significantly decreased the incidence of relapse, which translated into a trend for a better progres-sion- free survival.
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    • In this phase II study, 92 patients with relapsed Hodgkin's lymphoma were treated with salvage chemotherapy followed by reduced-intensity allogeneic transplantation. Seventy-eight patients proceeded to allograft. Fludarabine (150 mg/m(2) iv) and melphalan (140 mg/m(2) iv) were used as the conditioning regimen. The nonrelapse mortality rate was 8% at 100 days and 15% at 1 year. Relapse was the major cause of failure. The progression-free survival rate was 47% at 1 year and 18% at 4 years from trial entry. The overall survival rate was 71% at 1 year and 43% at 4 years. Chronic graft-versus-host disease was associated with a lower incidence of relapse. Patients allografted in complete remission had a significantly better outcome
    • •• Sureda A, Canals C, Arranz R, et al. Allogeneic stem cell transplantation after reduced intensity conditioning in patients with relapsed or refractory Hodgkin's lymphoma. Results of the HDR-ALLO study - a prospective clinical trial by the Grupo Español de Linfomas/Trasplante de Médula Osea (GEL/TAMO) and the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Haematologica. 2012;97:310-7. In this phase II study, 92 patients with relapsed Hodgkin's lymphoma were treated with salvage chemotherapy followed by reduced-intensity allogeneic transplantation. Seventy-eight patients proceeded to allograft. Fludarabine (150 mg/m(2) iv) and melphalan (140 mg/m(2) iv) were used as the conditioning regimen. The nonrelapse mortality rate was 8% at 100 days and 15% at 1 year. Relapse was the major cause of failure. The progression-free survival rate was 47% at 1 year and 18% at 4 years from trial entry. The overall survival rate was 71% at 1 year and 43% at 4 years. Chronic graft-versus-host disease was associated with a lower incidence of relapse. Patients allografted in complete remission had a significantly better outcome.
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    • Forty-nine patients with multiply relapsed Hodgkin's lymphoma were allografted using in vivo T-cell depletion as graft-versus-host disease prophylaxis. Eight of 49 (16%) had grade II-IV acute GVHD and 7 (14%) had chronic GVHD before donor-lymphocyte infusion. Sixteen (33%) patients received donor-lymphocyte infusion from 3 months after transplantation for residual disease or progression. Nonrelapse-related mortality was 16.3% at 730 days. Projected 4-year overall and progression-free survival were 55.7% and 39%, respectively
    • •• Peggs KS, Kayani I, Edwards N, et al. Donor lymphocyte infusions modulate relapse risk in mixed chimeras and induce durable salvage in relapsed patients after T-cell-depleted allogeneic transplantation for Hodgkin's lymphoma. J Clin Oncol. 2011;29:971-8. Forty-nine patients with multiply relapsed Hodgkin's lymphoma were allografted using in vivo T-cell depletion as graft-versus-host disease prophylaxis. Eight of 49 (16%) had grade II-IV acute GVHD and 7 (14%) had chronic GVHD before donor-lymphocyte infusion. Sixteen (33%) patients received donor-lymphocyte infusion from 3 months after transplantation for residual disease or progression. Nonrelapse-related mortality was 16.3% at 730 days. Projected 4-year overall and progression-free survival were 55.7% and 39%, respectively.
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    • The efficacy and safety of brentuximab vedotin were evaluated in patients with relapsed or refractory Hodgkin's lymphoma after autologous stem-cell transplantation. A total of 102 patients were treated with brentuximab vedotin 1.8 mg/kg by intravenous infusion every 3 weeks. In the absence of disease progression or prohibitive toxicity, patients received a maximum of 16 cycles. The overall response rate was 75% with complete remission in 34% of patients. The median progression-free survival time for all patients was 5.6 months, and the median duration of response for those in CR was 20.5 months. The most common treatment-related adverse events were peripheral sensory neuropathy, nausea, fatigue, neutropenia, and diarrhea
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    • • Thomson K, Kayani I, Ardeshna KM, et al. A response-adjusted PET-based transplantation strategy in primary resistant and relapsed Hodgkin lymphoma. Leukemia. 2013;27:1419-22. A response-adjusted transplantation algorithm using allogeneic stem cell transplantation with a BEAM-Campath conditioning protocol for those patients deemed to be at high risk of failure of autologous stem cell transplantation because of a metabolically active disease after first-line salvage chemotherapy is analyzed.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.