Masked and overt autoantibodies specific to the DPD epitope of 65-kDa glutamate decarboxylase (GAD65-DPD) are associated with preserved β-Cell functional reserve in ketosis-prone diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 6, 2014, Pages

  Oak, Shilpa ^a   Gaur, Lakshmi K ^a   Radtke, Jared ^a   Patel, Roshni ^b   Iyer, Dinakar ^b   Ram, Nalini ^b,c   Gaba, Ruchi ^b,c   Balasubramanyam, Ashok ^b,c   Hampe, Christiane S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c BEN TAUB GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE RESISTANCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; KETOSIS PRONE DIABETES; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AUTOANTIBODIES; CELL COUNT; DIABETES MELLITUS, TYPE 1; DIABETIC KETOACIDOSIS; EPITOPE MAPPING; EPITOPES; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INSULIN-SECRETING CELLS;

EID: 84902350020     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4189     Document Type: Article

References (19)

1. Maldonado M, Hampe CS, Gaur LK, et al. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab. 2003;88:5090-5098.
2. Balasubramanyam A, Garza G, Rodriguez L, et al. Accuracy and predictive value of classification schemes for ketosis-prone diabetes mellitus (KPDM). Diabetes Care. 2006;29:2575-2579.
3. N alini R, Ozer K, Maldonado M, et al. Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of "A-" ketosis-prone diabetes based on long-term-cell function, human leukocyte antigen class II alle les, and sex predilection. Metabolism. 2010;59:1448-1455.
4. Hampe CS, Nalini R, Maldonado MR, et al. Association of aminoterminal-specific anti-glutamate decarboxylase (GAD65) autoantibodies with-c ell functional reserve and a milder clinical phenotype in patients with GAD65 antibodies and ketosis prone diabetes mellitus. J Clin Endocrinol Metab. 2007;92:462-467.
5. Oak S, Gilliam LK, Landin-Olsson M, et al. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes. Proc Natl Acad Sci U S A. 2008;105:5471-5476.
6. Grubin CE,Daniels T,Toivola B,et al A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM Diabetologia. 1994 37 344-350.
7. Verge CF, Stenger D, Bonifacio E, et al. Combined use of autoantibodies (IA-2) autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoan tibody Workshop. Diabetes. 1998;47:1857-1866.
8. Routsias JG, Dotsika E, Touloupi E, et al. Idiotype-anti-idiotype circuit in non-autoimmune mice after immunization with the epitope and complementary epitope 289-308aa of La/SSB: implications for the maintenance and per petuation of the anti-La/SSB response. J Autoimmun. 2003;21:17-26.
9. Oak S, Radtke J, Landin-Olsson M, Torn C, Lernmark A, Hampe CS. Comparison of three assays for the detection of GAD65 Abspecific anti-idiotypic antibodies. J Immunol Methods. 2009;351: 55-61.
10. Nalini R, Gaur LK, Maldonado M, et al. HLA class II alleles specify phenotypes of ketosis-prone diabetes. Diabetes Care. 2008;31: 1195-1200.
11. Eisenbarth GS, Srikanta S, Fleischnick E, et al. Progressive autoimmune-cell insufficiency: occurrence in the absence of high-risk HLA alleles DR3, DR4. Diabetes Care. 1985;8:477-480.
12. Monos DS, Spielman RS, Gogolin KJ, et al. HLA-DQw3.2 allele of the DR4 haplotype is associated with insulin-dependent diabetes; correlation betweenDQ-restriction fragments andDQ-chain variation. Immunogenetics. 1987;26:299-303.
13. Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ β-chain protects against type 1 diabetes: a fa mily study. Proc Natl Acad Sci. 1988;85:8111-8115.
14. Knip M, Kukko M, Kulmala P, et al. Humoral-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet. 2002;115:48-54.
15. Kordonouri O, Hartmann R, Charpentier N, Knip M, Danne T, Ilonen J. Genetic risk markers related to diabetes-associated autoantibodies in y oung patients with type 1 diabetes in berlin, Germany. Exp Clin Endocrinol Diabetes. 2010;118:245-249.
16. Hagopian WA, Sanjeevi CB, Kockum I, et al. Glutamate decarboxylase-, insulin-and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest. 1995;95:1505-1511.
17. Graham J, Hagopian WA, Kockum I, et al; Diabetes Incidence in Sw eden Study Group, Swedish Childhood Diabetes Study Group. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes. 2002;51:1346-1355.
18. Brooks-Worrell BM, Iyer D, Coraza I, et al. Islet-specific T-cell responses and proinflammatory monocytes define subtypes of autoantibody-negative ketosis-prone diabetes (KPD). Diabetes Care. 2013; 36:4098-4103.
19. Ortqvist E, Brooks-Worrell B, Lynch K, et al. Changes in GAD65Ab-specific antiidiotypic antibody levels correlate with changes in C-peptide levels and progression to islet cell autoimmunity. J Clin Endocrinol Metab. 2010;95:E 310-E318.