Systematic investigation of the incorporation mechanisms of zolpidem in fingernails

Drug Testing and Analysis

Volumn 6, Issue 6, 2014, Pages 533-541

  Madry, Milena M ^a   Steuer, Andrea E ^a   Binz, Tina M ^a   Baumgartner, Markus R ^a   Kraemer, Thomas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Detection window; LC MS MS; Nail analysis; Single dose; Zolpidem

Indexed keywords

DRUG DOSAGE; DRUG PRODUCTS; ELECTRODEPOSITION; ELECTROSPRAY IONIZATION; EXTRACTION; LIQUID CHROMATOGRAPHY;

DETECTION WINDOWS; EXTERNAL CONTAMINATION; FORENSICS/ TOXICOLOGIES; INCORPORATION MECHANISM; LC-MS-MS; LC.MS/MS; NAIL ANALYSE; RING FINGER; SINGLE-DOSE; ZOLPIDEM;

MASS SPECTROMETRY;

ZOLPIDEM; HYPNOTIC SEDATIVE AGENT; PYRIDINE DERIVATIVE;

ARTICLE; DRUG BLOOD LEVEL; DRUG CONTAMINATION; DRUG DETERMINATION; DRUG MONITORING; DRUG-FACILITATED SEXUAL ASSAULT; ELECTROSPRAY MASS SPECTROMETRY; FINGER NAIL; FORENSIC TOXICOLOGY; HAIR ANALYSIS; HUMAN; HUMAN EXPERIMENT; HYGIENE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SWEAT; VALIDATION PROCESS; ADULT; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HAIR; LIMIT OF DETECTION; MIDDLE AGED; NAIL; PROCEDURES; SUBSTANCE ABUSE; TANDEM MASS SPECTROMETRY; TIME; VALIDATION STUDY;

ADULT; CHROMATOGRAPHY, LIQUID; FORENSIC TOXICOLOGY; HAIR; HUMANS; HYPNOTICS AND SEDATIVES; LIMIT OF DETECTION; MIDDLE AGED; NAILS; PYRIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 84902343608     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1558     Document Type: Article

References (41)

1. F. Pragst, M.A. Balikova. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta 2006, 370, 17.
2. G.L. Henderson. Mechanisms of drug incorporation into hair. Forensic Sci. Int. 1993, 63, 19.
3. E. Cone. Mechanisms of drug incorporation into hair. Ther. Drug Monit. 1996, 18, 438.
4. J.Y. Kim, J.C. Cheong, M.K. Kim, J.I. Lee, M.K. In. Simultaneous determination of amphetamine-type stimulants and cannabinoids in fingernails by gas chromatography-mass spectrometry. Arch. Pharm. Res. 2008, 31, 805.
5. J.Y. Kim, S.H. Shin, M.K. In. Determination of amphetamine-type stimulants, ketamine and metabolites in fingernails by gas chromatography-mass spectrometry. Forensic Sci. Int. 2010, 194, 108.
6. D.L. Lin, R.M. Yin, H.C. Liu, C.Y. Wang, R.H. Liu. Deposition characteristics of methamphetamine and amphetamine in fingernail clippings and hair sections. J. Anal. Toxicol. 2004, 28, 411.
7. O. Suzuki, H. Hattori, M. Asano. Nails as useful materials for detection of methamphetamine or amphetamine abuse. Forensic Sci. Int. 1984, 24, 9.
8. N.P. Lemos, R.A. Anderson, J.R. Robertson. The Analysis of methadone in nail clippings from patients in a methadone-maintenance program. J. Anal. Toxicol. 2000, 24, 656.
9. J.Y. Kim, J.C. Cheong, J.I. Lee, J.H. Son, M.K. In. Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction. J. Forensic Sci. 2012, 57, 228.
10. D. Garside, J.D. Ropero-Miller, B.A. Goldberger, W.F. Hamilton, W.R. Maples. Identification of cocaine analytes in fingernail and toenail specimens. J. Forensic Sci. 1998, 43, 974.
11. N.P. Lemos, R.A. Anderson, J.R. Robertson. Nail analysis for drugs of abuse: Extraction and determination of cannabis in fingernails by RIA and GC-MS. J. Anal. Toxicol. 1999, 23, 147.
12. L. Morini, M. Colucci, M. Ruberto, A. Groppi. Determination of ethyl glucuronide in nails by liquid chromatography tandem mass spectrometry as a potential new biomarker for chronic alcohol abuse and binge drinking behavior. Anal. Bioanal. Chem. 2012, 402, 1865.
13. J. Jones, M. Jones, C. Plate, D. Lewis, M. Fendrich, L. Berger, D. Fuhrmann. Liquid chromatography-tandem mass spectrometry assay to detect ethyl glucuronide in human fingernail: Comparison to hair and gender differences. Am. J. Anal. Chem. 2012, 3, 83.
14. G. Skopp, L. Potsch. A case report on drug screening of nail clippings to detect prenatal drug exposure. Ther. Drug Monit. 1997, 19, 386.
15. F. Mari, L. Politi, E. Bertol. Nails of newborns in monitoring drug exposure during pregnancy. Forensic Sci. Int. 2008, 179, 176.
16. A.Y. Finlay. Pharmacokinetics of terbinafine in the nail. Brit. J. Dermatol. 1992, 126, 28.
17. L. Matthieu, P. De Doncker, G. Cauwenbergh, R. Woestenborghs, V. van de Velde, P.A. Janssen, P. Dockx. Itraconazole penetrates the nail via the nail matrix and the nail bed--an investigation in onychomycosis. Clin. Exp. Dermatol. 1991, 16, 374.
18. P. Fleckman. Anatomy and physiology of the nail. Dermatol. Clin. 1985, 3, 373.
19. M. Johnson, S. Shuster. Continuous formation of nail along the bed. Brit. J. Dermatol. 1993, 128, 277.
20. R. Baran, R.P.R. Dawber, E. Haneke, A. Tosti, I. Bristow. A Text Atlas of Nail Disorders - Techniques in Investigation and Diagnosis. Martin Dunitz, London and New York, 2003.
21. C. Hang, X. Ping, S. Min. Long-term follow-up analysis of zolpidem in fingernails after a single oral dose. Anal. Bioanal. Chem. 2013, 405, 7281.
22. L.P. Carter. Potential impact of drug effects, availability, pharmacokinetics, and screening on estimates of drugs implicated in cases of assault. Drug Test. Anal. 2011, 3, 586.
23. T. Cairns, V. Hill, M. Schaffer, W. Thistle. Removing and identifying drug contamination in the analysis of human hair. Forensic Sci. Int. 2004, 145, 97.
24. ROTE LISTE Online - Fachinformation Zolpidem. FachInfo Service, Berlin, 2009.
25. K.Y. Rust, M.R. Baumgartner, N. Meggiolaro, T. Kraemer. Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS. Forensic Sci. Int. 2012, 215, 64.
26. F.T. Peters, M. Hartung, M. Herbold, G. Schmitt, T. Daldrup, F. Musshoff. Anhang B zur Richtlinie der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen. Anforderungen an die Validierung von Analysenmethoden. Toxichem. Krimtech. 2009, 76, 185.
27. B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 2003, 75, 3019.
28. F. Musshoff, G. Skopp, F. Pragst, H. Sachs, D. Thieme. Anhang C zur Richtlinie der GTFCh zur Qualitätssicherung bei forensisch-toxikologischen Untersuchungen. Anforderungen an die Untersuchung von Haarproben. Toxichem. Krimtech. 2009, 76, 209.
29. N. Orentreich, J. Markofsky, J.H. Vogelman. The effect of aging on the rate of linear nail growth. J. Invest. Dermatol. 1979, 73, 126.
30. W.E.L.G. Clark, L.H.D. Buxton. Studies in nail growth. Brit. J. Dermatol. 1938, 50, 221.
31. N. De Giovanni, N. Fucci. The current status of sweat testing for drugs of abuse: A review. Curr. Med. Chem. 2013, 20, 545.
32. A.L.S. Lorincz, R.B. Stoughton. Specific metabolic processes of skin. Physiol. Rev. 1958, 38, 481.
33. H. Laufen, T. Zimmermann, R.A. Yeates, T. Schumacher, A. Wildfeuer. The uptake of fluconazole in finger and toe nails. Int. J. Clin. Pharmacol. Ther. 1999, 37, 352.
34. C.S. Munro, S. Shuster. The route of rapid access of drugs to the distal nail plate. Acta Derm. Venerol. 1992, 72, 387.
35. P.R. Stout, J.D. Ropero-Miller, M.R. Baylor, J.M. Mitchell. External contamination of hair with cocaine: Evaluation of external cocaine contamination and development of performance-testing materials. J. Anal. Toxicol. 2006, 30, 490.
36. M.M. Madry, K.Y. Rust, R. Guglielmello, M.R. Baumgartner, T. Kraemer. Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure. Forensic Sci. Int. 2012, 223, 330.
37. R.R. Dawber. The ultrastructure and growth of human nails. Arch. Dermatol. Res. 1980, 269, 197.
38. R.I.C. Spearman, in The Physiology and Pathophysiology of the Skin, (Ed: K Jarrett ). Academic Press, London, 1978, pp. 1810-1855.
39. X. Cui, P. Xiang, J. Zhang, Y. Shi, B. Shen, M. Shen. Segmental hair analysis after a single dose of zolpidem: Comparison with a previous study. J. Anal. Toxicol. 2013, 37, 369.
40. M. Villain, M. Chèze, A. Tracqui, B. Ludes, P. Kintz. Windows of detection of zolpidem in urine and hair: Application to two drug facilitated sexual assaults. Forensic Sci. Int. 2004, 143, 157.
41. R.C. Irving, S.J. Dickson. The detection of sedatives in hair and nail samples using tandem LC-MS-MS. Forensic Sci. Int. 2006, 166, 58.