HuD regulates coding and noncoding RNA to induce APP→Aβ processing

Cell Reports

Volumn 7, Issue 5, 2014, Pages 1401-1409

  Kang, Min Ju ^a   Abdelmohsen, Kotb ^a   Hutchison, Emmette R ^a   Mitchell, Sarah J ^a   Grammatikakis, Ioannis ^a   Guo, Rong ^a   Noh, JiHeon ^a   Martindale, Jennifer L ^a   Yang, Xiaoling ^a   Lee, Eun Kyung ^a,e   Faghihi, Mohammad A ^b   Wahlestedt, Claes ^b   Troncoso, Juan C ^c   Pletnikova, Olga ^c   Perrone Bizzozero, Nora ^d   Resnick, Susan M ^a   deCabo, Rafael ^a   Mattson, Mark P ^a   Gorospe, Myriam ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; MESSENGER RNA; PROTEIN HUD; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; BACE1AS RNA; HUD PROTEIN; LONG UNTRANSLATED RNA; UNTRANSLATED RNA; 3' UNTRANSLATED REGION; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; ELAV PROTEIN; SECRETASE;

3' UNTRANSLATED REGION; ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACE1 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE CONTROL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TARGETING; RNA TRANSLATION; SUPERIOR TEMPORAL GYRUS; APP GENE; GENE EXPRESSION; HUMAN TISSUE; MOLECULAR PATHOLOGY; PROTEIN DNA INTERACTION; RNA STABILITY; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CASE CONTROL STUDY; GENETICS; METABOLISM; MIDDLE AGED; TUMOR CELL LINE; VERY ELDERLY;

MUS;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CASE-CONTROL STUDIES; CELL LINE, TUMOR; CEREBRAL CORTEX; ELAV PROTEINS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; RNA STABILITY; RNA, LONG NONCODING;

EID: 84902318203     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.04.050     Document Type: Article

References (23)

1. Abdelmohsen K., Hutchison E.R., Lee E.K., Kuwano Y., Kim M.M., Masuda K., Srikantan S., Subaran S.S., Marasa B.S., Mattson M.P., Gorospe M. miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol. Cell. Biol. 2010, 30:4197-4210.
2. Akamatsu W., Fujihara H., Mitsuhashi T., Yano M., Shibata S., Hayakawa Y., Okano H.J., Sakakibara S., Takano H., Takano T., et al. The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc. Natl. Acad. Sci. USA 2005, 102:4625-4630.
3. Anderson K.D., Sengupta J., Morin M., Neve R.L., Valenzuela C.F., Perrone-Bizzozero N.I. Overexpression of HuD accelerates neurite outgrowth and increases GAP-43 mRNA expression in cortical neurons and retinoic acid-induced embryonic stem cells invitro. Exp. Neurol. 2001, 168:250-258.
4. Bolognani F., Contente-Cuomo T., Perrone-Bizzozero N.I. Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets. Nucleic Acids Res. 2010, 38:117-130.
5. Deschênes-Furry J., Perrone-Bizzozero N.I., Jasmin B.J. The RNA-binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity. Bioessays 2006, 28:822-833.
6. Driscoll I., Troncoso J.C., Rudow G., Sojkova J., Pletnikova O., Zhou Y., Kraut M.A., Ferrucci L., Mathis C.A., Klunk W.E., et al. Correspondence between invivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathol. 2012, 124:823-831.
7. Fabian M.R., Sonenberg N., Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 2010, 79:351-379.
8. Faghihi M.A., Modarresi F., Khalil A.M., Wood D.E., Sahagan B.G., Morgan T.E., Finch C.E., St Laurent G., Kenny P.J., Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat. Med. 2008, 14:723-730.
9. Fukao A., Sasano Y., Imataka H., Inoue K., Sakamoto H., Sonenberg N., Thoma C., Fujiwara T. The ELAV protein HuD stimulates cap-dependent translation in a Poly(A)- and eIF4A-dependent manner. Mol. Cell 2009, 36:1007-1017.
10. Glisovic T., Bachorik J.L., Yong J., Dreyfuss G. RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett. 2008, 582:1977-1986.
11. Good P.J. A conserved family of elav-like genes in vertebrates. Proc. Natl. Acad. Sci. USA 1995, 92:4557-4561.
12. Hinman M.N., Lou H. Diverse molecular functions of Hu proteins. Cell. Mol. Life Sci. 2008, 65:3168-3181.
13. Kasashima K., Terashima K., Yamamoto K., Sakashita E., Sakamoto H. Cytoplasmic localization is required for the mammalian ELAV-like protein HuD to induce neuronal differentiation. Genes Cells 1999, 4:667-683.
14. Keene J.D., Tenenbaum S.A. Eukaryotic mRNPs may represent posttranscriptional operons. Mol. Cell 2002, 9:1161-1167.
15. Kullmann M., Göpfert U., Siewe B., Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev. 2002, 16:3087-3099.
16. Lee E.K., Kim H.H., Kuwano Y., Abdelmohsen K., Srikantan S., Subaran S.S., Gleichmann M., Mughal M.R., Martindale J.L., Yang X., et al. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat. Struct. Mol. Biol. 2010, 17:732-739.
17. Lee E.K., Kim W., Tominaga K., Martindale J.L., Yang X., Subaran S.S., Carlson O.D., Mercken E.M., Kulkarni R.N., Akamatsu W., et al. RNA-binding protein HuD controls insulin translation. Mol. Cell 2012, 45:826-835.
18. Moore M.J. From birth to death: the complex lives of eukaryotic mRNAs. Science 2005, 309:1514-1518.
19. Morris A.R., Mukherjee N., Keene J.D. Systematic analysis of posttranscriptional gene expression. Wiley Interdiscip. Rev. Syst. Biol. Med. 2010, 2:162-180.
20. Pascale A., Gusev P.A., Amadio M., Dottorini T., Govoni S., Alkon D.L., Quattrone A. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Proc. Natl. Acad. Sci. USA 2004, 101:1217-1222.
21. Pascale A., Amadio M., Quattrone A. Defining a neuron: neuronal ELAV proteins. Cell. Mol. Life Sci. 2008, 65:128-140.
22. Perrone-Bizzozero N.I., Tanner D.C., Mounce J., Bolognani F. Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice. ASN Neuro 2011, 3:259-270.
23. Yoon J.H., Abdelmohsen K., Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. J.Mol. Biol. 2013, 425:3723-3730.