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Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response
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Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG
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Ho, P.A., Kopecky, K.J., Alonzo, T.A., Gerbing, R.B., Miller, K.L., Kuhn, J., Zeng, R., Ries, R.E., Raimondi, S.C., Hirsch, B.A., Oehler, V., Hurwitz, C.A., Franklin, J.L., Gamis, A.S., Petersdorf, S.H., Anderson, J.E., Godwin, J.E., Reaman, G.H., Willman, C.L., Bernstein, I.D., Radich, J.P., Appelbaum, F.R., Stirewalt, D.L. & Meshinchi, S. (2011) Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG. Blood, 118, 4561-4566.
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Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: a Study by the Acute Leukemia French Association Group
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A 'silent' polymorphism in the MDR1 gene changes substrate specificity
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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
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Wagner, K., Damm, F., Göhring, G., Görlich, K., Heuser, M., Schäfer, I., Ottmann, O., Lübbert, M., Heit, W., Kanz, L., Schlimok, G., Raghavachar, A.A., Fiedler, W., Kirchner, H.H., Brugger, W., Zucknick, M., Schlegelberger, B., Heil, G., Ganser, A. & Krauter, J. (2010) Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor. Journal of Clinical Oncology, 28, 2356-2364.
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Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China
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Wang, J.H., Chen, W.L., Li, J.M., Wu, S.F., Chen, T.L., Zhu, Y.M., Zhang, W.N., Li, Y., Qiu, Y.P., Zhao, A.H., Mi, J.Q., Jin, J., Wang, Y.G., Ma, Q.L., Huang, H., Wu, D.P., Wang, Q.R., Yan, X.J., Yan, J.S., Li, J.Y., Wang, S., Huang, X.J., Wang, B.S., Jia, W., Shen, Y., Chen, Z. & Chen, S.J. (2013) Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. Proceedings of the National Academy of Sciences of the USA, 110, 17017-17022.
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The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization
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Ward, P.S., Lu, C., Cross, J.R., Abdel-Wahab, O., Levine, R.L., Schwartz, G.K. & Thompson, C.B. (2013) The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization. The Journal of Biological Chemistry, 288, 3804-3815.
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