In oesophageal squamous cells exposed to acidic bile salt medium, omeprazole inhibits IL-8 expression through effects on nuclear factor-κB and activator protein-1

Gut

Volumn 63, Issue 7, 2014, Pages 1042-1052

  Huo, Xiaofang ^a   Zhang, Xi ^a   Yu, Chunhua ^a   Zhang, Qiuyang ^a   Cheng, Edaire ^b   Wang, David H ^a   Pham, Thai H ^a   Spechler, Stuart J ^a   Souza, Rhonda F ^a  

^a VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; OMEPRAZOLE; PROTEIN C FOS; PROTEIN C JUN; TELOMERASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA;

ACIDITY; ADULT; ARTICLE; CELL ASSAY; CELL IMMORTALIZATION; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; ESOPHAGUS MUCOSA; ESOPHAGUS SQUAMOUS EPITHELIAL CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL; TRANSCRIPTION REGULATION;

CHEMOKINES; EPITHELIAL CELLS; GASTROESOPHAGEAL REFLUX DISEASE; MOLECULAR MECHANISMS; PROTON PUMP INHIBITION;

BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; CELL LINE; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; ESOPHAGITIS, PEPTIC; ESOPHAGUS; FEMALE; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NF-KAPPA B; OMEPRAZOLE; PROTON PUMP INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-1;

EID: 84902297758     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-305533     Document Type: Article

References (34)

1. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 2013;108:308-28.
2. Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory effects of proton pump inhibitors: A review and discussion of the clinical implications. Dig Dis Sci 2009;54:2312-17.
3. Handa O, Yoshida N, Fujita N, et al. Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors. Inflamm Res 2006;55:476-80.
4. Yoshida N, Yoshikawa T, Tanaka Y, et al. A new mechanism for anti-inflammatory actions of proton pump inhibitors-inhibitory effects on neutrophil-endothelial cell interactions. Aliment Pharmacol Ther 2000;14(Suppl 1):74-81. (Pubitemid 30199109)
5. Yoshida K, Kyo E, Tsuda T, et al. EGF and TGF-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells, act as autocrine growth factors. Int J Cancer 1990;45:131-5. (Pubitemid 20032110)
6. Sasaki T, Yamaya M, Yasuda H, et al. The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells. Eur J Pharmacol 2005;509:201-10. (Pubitemid 40279079)
7. Ohara T, Arakawa T. Lansoprazole decreases peripheral blood monocytes and intercellular adhesion molecule-1-positive mononuclear cells. Dig Dis Sci 1999;44:1710-15. (Pubitemid 29434749)
8. Cheng E, Zhang X, Huo X, et al. Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD. Gut 2013;62:824-32.
9. Zhang X, Cheng E, Huo X, et al. Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS One 2012;7:e50037.
10. Livstone EM, Sheahan DG, Behar J. Studies of esophageal epithelial cell proliferation in patients with reflux esophagitis. Gastroenterology 1977;73:1315-19. (Pubitemid 8229283)
11. Souza RF, Huo X, Mittal V, et al. Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury. Gastroenterology 2009;137:1776-84.
12. Huo X, Zhang HY, Zhang XI, et al. Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus. Gastroenterology 2010;139:194-203.
13. Zhang HY, Zhang X, Chen X, et al. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol 2008;295:G470-8.
14. Hauert AB, Martinelli S, Marone C, et al. Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int J Biochem Cell Biol 2002;34:838-54. (Pubitemid 34304172)
15. Ohsaka A, Hirota-Komatsu S, Shibata M, et al. Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells. Biochem Biophys Res Commun 2008;368:543-9.
16. Liu T, Zhang X, So CK, et al. Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis 2007;28:488-96. (Pubitemid 46321867)
17. Kauer WK, Peters JH, DeMeester TR, et al. Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 1997;122:874-81. (Pubitemid 27495927)
18. Richter JE, Bradley LA, DeMeester TR, et al. Normal 24-hr ambulatory esophageal pH values. Influence of study center, pH electrode, age, and gender. Dig Dis Sci 1992;37:849-56.
19. Shimotake TK, Izhar FM, Rumilla K, et al. Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway. Pediatr Res 2004;56:907-13. (Pubitemid 39552772)
20. Hoffmann E, Dittrich-Breiholz O, Holtmann H, et al. Multiple control of interleukin-8 gene expression. J Leukoc Biol 2002;72:847-55. (Pubitemid 35365158)
21. Souza RF, Shewmake KL, Shen Y, et al. Differences in ERK Activation in Squamous Mucosa in Patients Who Have Gastroesophageal Reflux Disease with and without Barrett's Esophagus. Am J Gastroenterol 2005;100:551-9. (Pubitemid 40487552)
22. Fitzgerald RC, Onwuegbusi BA, Bajaj-Elliott M, et al. Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut 2002;50:451-9. (Pubitemid 34638860)
23. Isomoto H, Wang A, Mizuta Y, et al. Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis. Am J Gastroenterol 2003;98:551-6. (Pubitemid 36348524)
24. Oh DS, DeMeester SR, Vallbohmer D, et al. Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery. Arch Surg 2007;142:554-9. (Pubitemid 46956405)
25. Bacon K, Baggiolini M, Broxmeyer H, et al. Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res 2002;22:1067-8.
26. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 1998;338:436-45. (Pubitemid 28135672)
27. Furie MB, Randolph GJ. Chemokines and tissue injury. Am J Pathol 1995;146:1287-301.
28. Mukaida N. Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol 2003;284:L566-77. (Pubitemid 36343304)
29. Naito Y, Yoshida N, Yoshikawa T. [Pro-inflammatory chemokine IL-8 in gastroesophageal reflux disease]. Nihon Rinsho 2004;62:1447-53.
30. Yamaguchi T, Yoshida N, Tomatsuri N, et al. Cytokine-induced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats. Int J Mol Med 2005;16:71-7.
31. Isomoto H, Saenko VA, Kanazawa Y, et al. Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy-negative gastroesophageal reflux disease. Am J Gastroenterol 2004;99:589-97. (Pubitemid 38607958)
32. Monkemuller K, Wex T, Kuester D, et al. Interleukin-1beta and interleukin-8 expression correlate with the histomorphological changes in esophageal mucosa of patients with erosive and non-erosive reflux disease. Digestion 2009;79:186-95.
33. Fujioka S, Niu J, Schmidt C, et al. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Mol Cell Biol 2004;24: 7806-19. (Pubitemid 39121503)
34. Yoshida N, Imamoto E, Uchiyama K, et al. Molecular mechanisms involved in interleukin-8 production by normal human oesophageal epithelial cells. Aliment Pharmacol Ther 2006;24:219-26.