A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

DMM Disease Models and Mechanisms

Volumn 7, Issue 6, 2014, Pages 649-657

  Carpinelli, Marina R ^a,b   Voss, Anne K ^b,c   Manning, Michael G ^a,b   Perera, Ashwyn A ^a   Cooray, Anne A ^b,c   Kile, Benjamin T ^b,c   Burt, Rachel A ^a,b  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Aspa; Aspartoacylase; Canavan disease; ENU mutagenesis; Leukodystrophy; Myelin

Indexed keywords

ASPARTOACYLASE; ETHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SPONGIOSIS; CANAVAN DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING IMPAIRMENT; LATENT PERIOD; LEUKODYSTROPHY; MALE; MOTOR COORDINATION; MOUSE; MOUSE MODEL; MYELIN DEFICIENCY; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; STARTLE REFLEX; ANIMAL; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASE; DISEASE MODEL; HEARING DISORDER; MUTANT MOUSE STRAIN; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; CANAVAN DISEASE; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; HEARING DISORDERS; MICE; MICE, MUTANT STRAINS;

EID: 84902281294     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.014605     Document Type: Article

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