The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Nakajima, Takahito ^a   Sato, Kazuhide ^a   Hanaoka, Hirofumi ^a   Watanabe, Rira ^a   Harada, Toshiko ^a   Choyke, Peter L ^a   Kobayashi, Hisataka ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytotoxicity; Light dose; Near infrared light; Necrosis; Photoimmunotherapy

Indexed keywords

ADENOSINE TRIPHOSPHATE; PANITUMUMAB; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; PHOTOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER THERAPY; CONTINUOUS PROCESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; FEMALE; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INFRARED RADIATION; LIGHT INTENSITY; MOUSE; NONHUMAN; PHOTOCHEMOTHERAPY; PHOTOIMMUNOTHERAPY; TREATMENT RESPONSE; BIOSYNTHESIS; BREAST NEOPLASMS; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; PATHOLOGY; PHOTOTHERAPY; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOTHERAPY; PHOTOSENSITIZING AGENTS; PHOTOTHERAPY; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84902276085     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-389     Document Type: Article

References (15)

1. Mitsunaga M, Ogawa M, Kosaka N, Rosenblum LT, Choyke PL, Kobayashi H. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med 2011, 17:1685-1691. 10.1038/nm.2554, 3233641, 22057348.
2. Nakajima T, Sano K, Choyke PL, Kobayashi H. Improving the efficacy of Photoimmunotherapy (PIT) using a cocktail of antibody conjugates in a multiple antigen tumor model. Theranostics 2013, 3:357-365. 10.7150/thno.5908, 3677407, 23781283.
3. Mitsunaga M, Nakajima T, Sano K, Choyke PL, Kobayashi H. Near-infrared theranostic photoimmunotherapy (PIT): repeated exposure of light enhances the effect of immunoconjugate. Bioconjug Chem 2012, 23:604-609. 10.1021/bc200648m, 3401044, 22369484.
4. Mitsunaga M, Nakajima T, Sano K, Kramer-Marek G, Choyke PL, Kobayashi H. Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy. BMC Cancer 2012, 12:345. 10.1186/1471-2407-12-345, 3502522, 22873679.
5. Sano K, Mitsunaga M, Nakajima T, Choyke PL, Kobayashi H. Acute Cytotoxic Effects of Photoimmunotherapy Assessed by 18 F-FDG PET. J Nucl Med 2013, 54:770-775. 10.2967/jnumed.112.112110, 23536226.
6. Lyakhov I, Zielinski R, Kuban M, Kramer-Marek G, Fisher R, Chertov O, Bindu L, Capala J. HER2- and EGFR-specific affiprobes: novel recombinant optical probes for cell imaging. Chembiochem 2010, 11:345-350. 10.1002/cbic.200900532, 3092587, 20052708.
7. Hoffman RM. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer 2005, 5:796-806. 10.1038/nrc1717, 16195751.
8. Hoffman RM, Yang M. Subcellular imaging in the live mouse. Nat Protoc 2006, 1:775-782. 10.1038/nprot.2006.109, 17406307.
9. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M, Hoffman RM. Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 2006, 5:1198-1201. 10.4161/cc.5.11.2795, 16760659.
10. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR, Hoffman RM. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res 2004, 64:4251-4256. 10.1158/0008-5472.CAN-04-0643, 15205338.
11. Kimura H, Lee C, Hayashi K, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, Bouvet M, Hoffman RM. UV light killing efficacy of fluorescent protein-expressing cancer cells in vitro and in vivo. J Cell Biochem 2010, 110:1439-1446. 10.1002/jcb.22693, 20506255.
12. Tsai MH, Aki R, Amoh Y, Hoffman RM, Katsuoka K, Kimura H, Lee C, Chang CH. GFP-fluorescence-guided UVC irradiation inhibits melanoma growth and angiogenesis in nude mice. Anticancer Res 2010, 30:3291-3294.
13. Shimomura O. Discovery of green fluorescent protein (GFP) (Nobel Lecture). Angew Chem Int Ed Engl 2009, 48:5590-5602. 10.1002/anie.200902240, 19579247.
14. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Bulgakova NN, Endo I, Hoffman RM. Fluorescent proteins enhance UVC PDT of cancer cells. Anticancer Res 2012, 32:4327-4330.
15. Momiyama M, Suetsugu A, Kimura H, Kishimoto H, Aki R, Yamada A, Sakurada H, Chishima T, Bouvet M, Endo I, Hoffman RM. Imaging the efficacy of UVC irradiation on superficial brain tumors and metastasis in live mice at the subcellular level. J Cell Biochem 2013, 114:428-434. 10.1002/jcb.24381, 22961687.