Relation of t-wave alternans to mortality and nonsustained ventricular tachycardia in patients with non-st-segment elevation acute coronary syndrome from the MERLIN-TIMI 36 Trial of ranolazine versus placebo

American Journal of Cardiology

Volumn 114, Issue 1, 2014, Pages 17-23

  Nieminen, Tuomo ^a,b,c   Scirica, Benjamin M ^c,d   Pegler, Jose R M ^b,e   Tavares, Caio ^b,e   Pagotto, Vitor P F ^b,e   Kanas, Alexandre F ^b,e   Sobrado, Marcel F ^b,e   Nearing, Bruce D ^b,c   Umez Eronini, Amarachi A ^d   Morrow, David A ^c,d   Belardinelli, Luiz ^f   Verrier, Richard L ^b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; RANOLAZINE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR MORTALITY; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPH; FEMALE; FOLLOW UP; HEART DEATH; HEART LEFT VENTRICLE EJECTION FRACTION; HEART VENTRICLE TACHYCARDIA; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; NON SUSTAINED VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); T WAVE; T WAVE ALTERANS;

ACETANILIDES; ACUTE CORONARY SYNDROME; AGED; ARRHYTHMIAS, CARDIAC; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; ENZYME INHIBITORS; FEMALE; HEART CONDUCTION SYSTEM; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; PLACEBOS; PREDICTIVE VALUE OF TESTS; RISK FACTORS; TACHYCARDIA, VENTRICULAR; TREATMENT OUTCOME;

EID: 84902266355     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2014.03.056     Document Type: Article

References (28)

1. R.L. Verrier, T. Klingenheben, M. Malik, N. El-Sherif, D. Exner, S. Hohnloser, T. Ikeda, J.P. Martinez, S. Narayan, T. Nieminen, and D.S. Rosenbaum Microvolt T-wave alternans: physiologic basis, methods of measurement, and clinical utility - Consensus guideline by the International Society for Holter and Noninvasive Electrocardiology J Am Coll Cardiol 44 2011 1309 1324
2. A.S. Go, D. Mozaffarian, V.L. Roger, E.J. Benjamin, J.D. Berry, M.J. Blaha, S. Dai, E.S. Ford, C.S. Fox, S. Franco, H.J. Fullerton, C. Gillespie, S.M. Hailpern, J.A. Heit, V.J. Howard, M.D. Huffman, S.E. Judd, B.M. Kissela, S.J. Kittner, D.T. Lackland, J.H. Lichtman, L.D. Lisabeth, R.H. Mackey, D. Magid, G.M. Marcus, A. Marelli, D.B. Matchar, D.K. McGuire, E.R. Mohler, C.S. Moy, M.E. Mussolino, R.W. Neumar, G. Nichol, D.K. Pandey, N.P. Paynter, M.J. Reeves, P.D. Sorlie, J. Stein, A. Towfighi, T.N. Turan, S.S. Virani, N.D. Wong, D. Woo, and M.B. Turner Heart disease and stroke statistics - 2014 update: a report from the American Heart Association Circulation 129 2014 e28 e292
3. D.A. Morrow Cardiovascular risk prediction in patients with stable and unstable coronary heart disease Circulation 121 2010 2681 2691
4. B.M. Scirica Acute coronary syndrome: emerging tools for diagnosis and risk assessment J Am Coll Cardiol 55 2010 1403 1415
5. B.D. Nearing, and R.L. Verrier Modified moving average method for T-wave alternans analysis with high accuracy to predict ventricular fibrillation J Appl Physiol 92 2002 541 549
6. R.L. Verrier, and T. Ikeda Ambulatory ECG-based T-wave alternans monitoring for risk assessment and guiding medical therapy: mechanisms and clinical applications Prog Cardiovasc Dis 56 2013 172 185
7. D.A. Morrow, B.M. Scirica, E. Karwatowska-Prokopczuk, S.A. Murphy, A. Budaj, S. Varshavsky, A.A. Wolff, A. Skene, C.H. McCabe, and E. Braunwald Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial JAMA 297 2007 1775 1783
8. B.M. Scirica, E. Braunwald, L. Belardinelli, C.M. Hedgepeth, J. Spinar, W. Wang, J. Qin, E. Karwatowska-Prokopczuk, F.W. Verheugt, and D.A. Morrow Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndrome-Thrombolysis In Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial Circulation 122 2010 455 462
9. A. Zanobetti, P.H. Stone, F.E. Speizer, J.D. Schwartz, B.A. Coull, H. Suh, B.D. Nearing, M.A. Mittleman, R.L. Verrier, and D.R. Gold T-wave alternans, air pollution and traffic in high-risk subjects Am J Cardiol 104 2009 665 670
10. R.L. Verrier, B.D. Nearing, R.N. Ghanem, R.E. Olson, R.F. Garberich, W.T. Katsiyiannis, C.C. Gornick, C.Y. Tang, and T.D. Henry Elevated T-wave alternans predicts nonsustained ventricular tachycardia in association with percutaneous coronary intervention in ST-segment elevation myocardial infarction (STEMI) patients J Cardiovasc Electrophysiol 24 2013 658 663
11. J.L. Anderson, C.D. Adams, E.M. Antman, C.R. Bridges, R.M. Califf, D.E. Casey, W.E. Chavey, F.M. Fesmire, J.S. Hochman, T.N. Levin, A.M. Lincoff, E.D. Peterson, P. Theroux, N.K. Wenger, R.S. Wright, and S.C. Smith 2011 ACC/AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 123 2011 e426 e579
12. B.M. Scirica, D.A. Morrow, H. Hod, S.A. Murphy, L. Belardinelli, C.M. Hedgepeth, P. Molhoek, F.W. Verheugt, B.J. Gersh, C.H. McCabe, and E. Braunwald Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non ST-Elevation Acute Coronary Syndrome Thrombolysis in Myocardial Infarction 36 (MERLIN-TIMI 36) randomized controlled trial Circulation 116 2007 1647 1652
13. D.P. Zipes, A.J. Camm, M. Borggrefe, A.E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A.J. Moss, R.J. Myerburg, S.G. Priori, M.A. Quinones, D.M. Roden, M.J. Silka, C. Tracy, S.C. Smith Jr., A.K. Jacobs, C.D. Adams, E.M. Antman, J.L. Anderson, S.A. Hunt, J.L. Halperin, R. Nishimura, J.P. Ornato, R.L. Page, B. Riegel, J.J. Blanc, A. Budaj, V. Dean, J.W. Deckers, C. Despres, K. Dickstein, J. Lekakis, K. McGregor, M. Metra, J. Morais, A. Osterspey, J.L. Tamargo, and J.L. Zamorano ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Circulation 114 2006 e385 e484
14. J.J. Goldberger, M.E. Cain, S.H. Hohnloser, A.H. Kadish, B.P. Knight, M.S. Lauer, B.J. Maron, R.L. Page, R.S. Passman, D. Siscovick, W.G. Stevenson, and D.P. Zipes American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention Circulation 118 2008 1497 1518
15. K. Hoshida, Y. Miwa, M. Miyakoshi, T. Tsukada, S. Yusu, H. Yoshino, and T. Ikeda Simultaneous assessment of T-wave alternans and heart rate turbulence on Holter electrocardiograms as predictors for serious cardiac events in patients after myocardial infarction Circ J 77 2013 432 438
16. L.-N. Ren, X.-H. Fang, L.-D. Ren, J. Gong, Y. Wang, and G. Qi Ambulatory ECG-based T-wave alternans and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus Cardiovasc Diabetol 11 2012 104 111
17. V. Sulimov, E. Okisheva, and D. Tsaregorodtsev Non-invasive risk stratification for sudden cardiac death by heart rate turbulence and microvolt T wave alternans in patients after myocardial infarction Europace 14 2012 1786 1792
18. K. Sakaki, T. Ikeda, Y. Miwa, M. Miyakoshi, A. Abe, T. Tsukada, H. Ishiguro, H. Mera, S. Yusu, and H. Yoshino Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study Heart Rhythm 6 2009 332 337
19. H. Shimada, M. Nishizaki, H. Fujii, N. Yamawake, S. Fukamizu, H. Sakurada, and M. Hiraoka Ambulatory electrocardiogram-based T-wave alternans in patients with vasospastic angina during asymptomatic periods Am J Cardiol 110 2012 1446 1451
20. P.K. Stein, D. Sanghavi, N. Sotoodehnia, D.S. Siscovick, and J. Gottdiener Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health Study J Electrocardiol 43 2010 251 259
21. V. Shusterman, A. Goldberg, and B. London Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans Circulation 113 2006 2880 2887
22. N. Takasugi, T. Kubota, K. Nishigaki, R.L. Verrier, M. Kawasaki, M. Takasugi, H. Ushikoshi, A. Hattori, S. Ojio, T. Aoyama, G. Takemura, and S. Minatoguchi Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome Europace 13 2011 708 715
23. T. Nieminen, D.Y. Nanbu, I.P. Datti, G.R. Vaz, C.A.M. Tavares, J.R.M. Pegler, B.D. Nearing, L. Belardinelli, and R.L. Verrier Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model Heart Rhythm 8 2011 608 614
24. R.L. Verrier, and T. Nieminen T-wave alternans as a therapeutic marker for antiarrhythmic agents J Cardiovasc Pharmacol 55 2010 544 554
25. D.K. Murdock, J. Kaliebe, and N. Overton Ranolazine-induced suppression of ventricular tachycardia in a patient with nonischemic cardiomyopathy: a case report Pacing Clin Electrophysiol 31 2008 765 768
26. C. Antzelevitch, A. Burashnikov, S. Sicouri, and L. Belardinelli Electrophysiologic basis for the antiarrhythmic actions of ranolazine Heart Rhythm 8 2011 1281 1290
27. N. Morita, J.H. Lee, Y. Xie, A. Sovari, Z. Qu, J.N. Weiss, and H.S. Karagueuzian Suppression of reentrant and multifocal ventricular fibrillation by the late Na current blocker ranolazine J Am Coll Cardiol 57 2011 366 375
28. R.L. Verrier, K. Kumar, T. Nieminen, and L. Belardinelli Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation Europace 15 2013 317 324