Evaluation of radioprotective effect of pilocarpine ingestion on salivary glands

Anticancer Research

Volumn 34, Issue 4, 2014, Pages 1993-2000

  Pimentel, Marcele Jardim ^a   Batista Filho, Mário Márcio Vasconcelos ^b   Araújo, Mariângela ^b   Queiroga Gomes, Daliana ^c   Da Costa, Lino João ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c STATE UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Pilocarpine; Radiotherapy; Xerostomia

Indexed keywords

PILOCARPINE; RADIOPROTECTIVE AGENT;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEAD AND NECK CANCER; HUMAN; HYPOSALIVATION; MALE; MOUTH DISEASE; PROSPECTIVE STUDY; RADIATION INJURY; RADIATION PROTECTION; RANDOMIZED CONTROLLED TRIAL; SALIVARY GLAND; SALIVATION; XEROSTOMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; HEAD AND NECK TUMOR; ORAL DRUG ADMINISTRATION; RADIATION EXPOSURE; RADIOTHERAPY; TREATMENT OUTCOME;

PILOCARPINE; RADIOTHERAPY; XEROSTOMIA;

ADMINISTRATION, ORAL; HEAD AND NECK NEOPLASMS; HUMANS; PILOCARPINE; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY; SALIVARY GLANDS; TREATMENT OUTCOME; XEROSTOMIA;

EID: 84902252513     PISSN: 02507005     EISSN: 17917530     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Ohrn KE, Wahlin YB and Sjödén PO: Oral status during radiotherapy and chemotherapy: a descriptive study of patient experiences and the occurrence of oral complications. Support Care Cancer 9 (4): 247-257, 2001.
2. Jensen SB, Pedersen AM, Reibel J and Nauntofte B: Xerostomia and hypofunction of the salivary glands in cancer therapy. Support Care Cancer 11(4): 207-225, 2003.
3. Vissink A, Jansma J, Spijkervet FKL, Burlage FR and Coppes RP: Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med 14(3): 199-212, 2003.
4. Logemann JA, Smith CH, Pauloski BR, Rademaker AW, Lazarus CL, Colangelo LA,Mittal B, MacCracken E, Gaziano J, Stachowiak L and Newman LA: Effects of xerostomia on perception and performance of swallow function. Head Neck 23(4): 317-321, 2003.
5. Rieger JM, Jha N, Tang JAL, Harris J and Seikaly H: Functional outcomes related to the prevention of radiation-induced xerostomia: Oral pilocarpine versus submandibular salivary gland transfer. Head Neck 34(2): 168-174, 2012.
6. Burlage FR, Coppes RP, Meertens H, Stokman MA and Vissink A: Parotid and submandibular/sublingual salivary flow during high-dose radiotherapy. Radiother Oncol 61(3): 271-273, 2001.
7. Gall F, Colella G, Di Onofrio V, Rossiello R, Angelillo IF and Liguori G: Candida spp. in oral cancer and oral precancerous lesion. New Microbiol 36(3): 283-288, 2013.
8. Silva ARS, Alves FA, Antunes A, Goes MF and Lopes MA: Patterns of demineralization and dentin reactions in radiation-related caries. Caries Res 43(1): 43-49, 2009.
9. Taylor SE and Miller EG: Pre-emptive pharmacologic intervention in radiation-induced salivary dysfunction. Proc Soc Exp Biol Med 222(1): 14-26, 1999.
10. Kielbassa AM, Hinkelbein W, Hellwig E and Meyer-Lückel H: Radiation-related damage to dentition. Lancet Oncol 7(4): 326-335, 2006.
11. Horiot JC, Lipinski F, Schraub S, Maulard-Durdux C, Bensadoun RJ, Ardiet JM, Coscas Y, Baillet F, Coche-Dequéant B, Urbajtel M, Montbarbon X, Bourdin S, Wibault M, Alfonsi M, Calais G, Desprez P, Pene F, Lapeyre M, Vinke J and Maral J.: Post-radiation severe xerostomia relieved by pilocarpine: A prospective French cooperative study. Radiother Oncol 55(3): 233-239, 2000.
12. Bonan PRF, Pires FR, Lopes MA and Hipolito O Jr.: Evaluation of salivary flor in patients during head and neck radiotherapy. Pesqui Odontol Bras 17(2): 156-160, 2003.
13. Shafer WG, Hine MK, Levy BM and Tomich CE: A Textbook of Oral Pathology. Fourth Edition. Philadelphia: Saunders, 1983.
14. Batista Neto C. Pilocarpine as a Therapeutic Tool in Post-irradiation Xerostomy. Dissertation. Universidade of Sao Paulo, 2003.
15. Hamlar DD, Schuller DE, Gahbauer RA, Buerki RA, Staubus AE, Hall J, Altman JS, Elzinga DJ and Martin MR: Determination of the efficacy of topical oral pilocarpine for postrradiation xerostomia in patients with head and neck carcinoma. Laryngoscope 106(8): 972-976, 1996.
16. Vissink A, Burlage FR, Spijkervet FKL, Veerman ACI and Nieuw Amerongen AV: Prevention and treatment of salivary gland hypofunction related to head and neck radiation therapy an chemotherapy. Support Cancer Ther 1(2): 111-118, 2004.
17. Taweechaisupapong S, Pesee M, Aromdee C, Laopaiboon M and Khunkitti W: Efficacy of pilocarpine lozenge for post-radioation xerostomia in patients with head and neck cancer. Aust Dent J 51(4): 333-337, 2006.
18. Looström H, Akerman S, Ericson D, Tobin G, Götrick B: Tramadol-induced oral dryness and pilocarpine treatment: effects on total protein and IgA. Arch Oral Biol 56(4): 395-400, 2011.
19. Jha N, Seikaly H, Harris J, Williams D, Sultanem K, Hier M, Ghosh S, Black M, Butler J, Sutherland D, Kerr P and Barnaby P: Phase III randomized study: Oral pilocarpine versus submandibular salivary gland transfer protocol for the management of radiation-induced xerostomia. Head Neck 31(2): 234-243, 2009.
20. Qi B, Narita T, Sugiya H and Murakami M: Pilocarpine-induced salivary fluid secretion in the perfused submandibular gland of the rat. J Med Invest 56 Suppl: 281-283, 2009.
21. Mattioli TMF, Silva S, Grégio AMT, Machado MAN, Lima AAS and Azevedo-Alanis LR: The effects of antidepressants and pilocarpine on rat parotid glands: an immunohistochemical study. Clinics (Sao Paulo) 66(9): 1605-1610, 2011.
22. WHO Handbook for Reporting Results of Cancer Treatment. WHO Offset publication No. 48, World Health Organization, Geneva, 1979.
23. Miller AB, Hoogstraten B, Staquet M and Winkler A: Reporting results of cancer treatment. Cancer 47(1): 207-214, 1981.
24. Ferguson MM, Hayes P, Highton J, Jones DS, MacFadyen EE and Palmer DG: Pilocarpine Oral Solution. Br Dental J 170(7): 251, 1991.
25. Johnson JT, Ferretti GA, Nethery WJ, Valdez IH, Fox PC, Ng D, Muscoplat CC and Gallagher SC: Oral pilocarpine for postirradiation xerostomia in patients with head and neck cancer. N Engl J Med 329(6): 390-395, 1993.
26. Burlage FR, Roesink JM, Kampinga HH, Coppes RP, Terhaard C, Langendijk JA,van Luijk P, Stokman MA and Vissink A: Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study. Int J Radiat Oncol Biol Phys 70(1): 14-22, 2008.
27. Koseki M, Maki Y, Matsukubo T, Ohashi Y and Tsubota K: Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes. Oral Dis 10(2): 75-80, 2004.
28. Almeida JPA and Kowalski LP: Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine theraoy: A pilot study. Braz J Otorhinolaryngol 76(5): 659-662, 2010.