Monitoring of internet forums to evaluate reactions to the introduction of reformulated oxycontin to deter abuse

Journal of Medical Internet Research

Volumn 16, Issue 5, 2014, Pages

  McNaughton, Emily C ^a   Coplan, Paul M ^b,c   Black, Ryan A ^d   Weber, Sarah E ^a   Chilcoat, Howard D ^b,e   Butler, Stephen F ^a  

^a INFLEXXION INC   (United States)

^b PURDUE PHARMA L P   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NOVA SOUTHEASTERN UNIVERSITY   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Drug abuse; Epidemiology; Internet; Opioid analgesic; OxyContin; Prescription drug; Qualitative research; Social media; Surveillance

Indexed keywords

ACETAMINOPHEN, HYDROCODONE DRUG COMBINATION; DRUG COMBINATION; HYDROCODONE; HYDROMORPHONE; NARCOTIC ANALGESIC AGENT; OXYCODONE; PARACETAMOL;

CHEMISTRY; DRUG COMBINATION; HUMAN; INTERNET; MEDICINAL CHEMISTRY; OPIOID-RELATED DISORDERS; SOCIAL MEDIA;

ACETAMINOPHEN; ANALGESICS, OPIOID; CHEMISTRY, PHARMACEUTICAL; DRUG COMBINATIONS; HUMANS; HYDROCODONE; HYDROMORPHONE; INTERNET; OPIOID-RELATED DISORDERS; OXYCODONE; SOCIAL MEDIA;

EID: 84902243141     PISSN: None     EISSN: 14388871     Source Type: Journal    
DOI: 10.2196/jmir.3397     Document Type: Article

References (21)

1. Office of National Drug Control Policy. Epidemic: Responding to America's Prescription Drug Crisis. Washington, DC: Executive Office of the President of the United States; 2011. URL: http://www.whitehouse.gov/sites/default/files/ ondcp/policy-and-research/rx-abuse-plan.pdf [accessed 2013-02-08] [WebCite Cache ID 6O3696g2Q]
2. US Food and Drug Administration. Transcript for the October 21 Joint Meeting of the Anesthetic and Life Support Drugs Advisory Committee and Drug Safety and Risk Managment Advisory Committee. 2010. URL: http://www.fda.gov/ downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/ AnestheticAndAnalgesicDrugProductsAdvisoryCommittee/UCM236243.pdf [accessed 2013-02-08] [WebCite Cache ID 6O38A7lcc]
3. Katz NP, Adams EH, Benneyan JC, Birnbaum HG, Budman SH, Buzzeo RW, et al. Foundations of opioid risk management. Clin J Pain 2007 Feb; 23(2): 103-118. [doi: 10.1097/01.ajp.0000210953.86255.8f] [Medline: 17237659]
4. Budman SH, Grimes Serrano JM, Butler SF. Can abuse deterrent formulations make a difference? Expectation and speculation. Harm Reduct J 2009; 6: 8 [FREE Full text] [doi: 10.1186/1477-7517-6-8] [Medline: 19480676]
5. Katz N. Abuse-deterrent opioid formulations: are they a pipe dream? Curr Rheumatol Rep 2008 Jan; 10(1): 11-18. [Medline: 18457606]
6. Raffa RB, Pergolizzi JV. Opioid formulations designed to resist/deter abuse. Drugs 2010 Sep 10; 70(13): 1657-1675. [doi: 10.2165/11537940-000000000- 00000] [Medline: 20731474]
7. US Food and Drug Administration. Guidance for Industry: Abuse-Deterrent Opioids - Evaluation and Labeling: Draft Guidance. 2013 Jan. URL: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/UCM334743.pdf [accessed 2013-02-08] [WebCite Cache ID 6O38Bf0pg]
8. Butler SF, Cassidy TA, Chilcoat H, Black RA, Landau C, Budman SH, et al. Abuse rates and routes of administration of reformulated extended-release oxycodone: initial findings from a sentinel surveillance sample of individuals assessed for substance abuse treatment. J Pain 2013 Apr; 14(4): 351-358. [doi: 10.1016/j.jpain.2012.08.008] [Medline: 23127293]
9. Cicero TJ, Ellis MS, Surratt HL. Effect of abuse-deterrent formulation of OxyContin. N Engl J Med 2012 Jul 12; 367(2): 187-189. [doi: 10.1056/NEJMc1204141] [Medline: 22784140]
10. Coplan PM, Kale H, Sandstrom L, Landau C, Chilcoat HD. Changes in oxycodone and heroin exposures in the National Poison Data System after introduction of extended-release oxycodone with abuse-deterrent characteristics. Pharmacoepidemiol Drug Saf 2013 Dec; 22(12): 1274-1282. [doi: 10.1002/pds.3522] [Medline: 24123484]
11. Severtson SG, Bartelson BB, Davis JM, Muñoz A, Schneider MF, Chilcoat H, et al. Reduced abuse, therapeutic errors, and diversion following reformulation of extended-release oxycodone in 2010. J Pain 2013 Oct; 14(10): 1122-1130. [doi: 10.1016/j.jpain.2013.04.011] [Medline: 23816949]
12. McNaughton EC, Black RA, Zulueta MG, Budman SH, Butler SF. Measuring online endorsement of prescription opioids abuse: an integrative methodology. Pharmacoepidemiol Drug Saf 2012 Oct; 21(10): 1081-1092. [doi: 10.1002/pds.3307] [Medline: 22777908]
13. Boyer EW, Shannon M, Hibberd PL. The Internet and psychoactive substance use among innovative drug users. Pediatrics 2005 Feb; 115(2): 302-305. [doi: 10.1542/peds.2004-1199] [Medline: 15687436]
14. The National Center on Addiction and Substance Abuse at Columbia University. "You've Got Drugs !" Prescription Drug Pushers on the Internet 2006 Update. 2006. URL: http://www.casacolumbia.org/download/file/fid/ 556 [accessed 2013-02-08] [WebCite Cache ID 6O38DWppH]
15. Cone EJ. Ephemeral profiles of prescription drug and formulation tampering: evolving pseudoscience on the Internet. Drug Alcohol Depend 2006 Jun; 83 Suppl 1: S31-S39. [doi: 10.1016/j.drugalcdep.2005.11.027] [Medline: 16458455]
16. Wax PM. Just a Click Away: Recreational Drug Web Sites on the Internet. PEDIATRICS 2002 Jun 01; 109(6): e96-e96. [doi: 10.1542/peds.109.6.e96] [Medline: 12042590]
17. Butler S, Katz N, Venuti S, Benoit C, Beaulaurier R. Content analysis and monitoring of Internet prescription opioid abuse-related postings. The Journal of Pain 2006 Apr; 7(4): S86-S28. [doi: 10.1016/j.jpain.2006.01.350]
18. Butler SF, Venuti SW, Benoit C, Beaulaurier RL, Houle B, Katz N. Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings. Clin J Pain 2007 Sep; 23(7): 619-628. [doi: 10.1097/AJP.0b013e318125c5cf] [Medline: 17710013]
19. Butler SF, Fernandez KC, Chang A, Benoit C, Morey LC, Black R, et al. Measuring attractiveness for abuse of prescription opioids. Pain Med 2010 Jan; 11(1): 67-80. [doi: 10.1111/j.1526-4637.2009.00736.x] [Medline: 20002325]
20. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977 Mar; 33(1): 159-174. [Medline: 843571]
21. Snijders T, Bosker RJ. Multilevel Analysisan Itroduction to Basic and Advanced Multilevel Modeling. London: Sage Publishers; 2012.