A study of plaque vascularization and inflammation using quantitative contrast-enhanced US and PET/CT

European Journal of Radiology

Volumn 83, Issue 7, 2014, Pages 1184-1189

  Hjelmgren, Ola ^a,b   Johansson, Lars ^c   Prahl, Ulrica ^a   Schmidt, Caroline ^a   Fredén Lindqvist, Johan ^b   Bergström, Göran M L ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Carotid artery plaque; Positron emission tomography; Ultrasound

Indexed keywords

FLUORODEOXYGLUCOSE F 18; IOVERSOL; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ALGORITHM; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; FEMALE; HUMAN; IMAGE ANALYSIS; INFLAMMATION; JUGULAR VEIN; MALE; MEDICAL HISTORY; NON INVASIVE PROCEDURE; PET-CT SCANNER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIATION DOSE; TRANSIENT ISCHEMIC ATTACK; ULTRASOUND; VASCULARIZATION; CAROTID ARTERY DISEASES; COMPUTER ASSISTED DIAGNOSIS; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC USE; ECHOGRAPHY; IMAGE ENHANCEMENT; METABOLIC CLEARANCE RATE; METABOLISM; MIDDLE AGED; MULTIMODAL IMAGING; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

AGED; CAROTID ARTERY DISEASES; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MULTIMODAL IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY;

EID: 84902239296     PISSN: 0720048X     EISSN: 18727727     Source Type: Journal    
DOI: 10.1016/j.ejrad.2014.03.021     Document Type: Article

References (27)

1. M.L. Flaherty, B. Kissela, and J.C. Khoury et al. Carotid artery stenosis as a cause of stroke Neuroepidemiology 40 2013 36 41
2. M. Naghavi, P. Libby, and E. Falk et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I Circulation 108 2003 1664 1672
3. T. Thim, M.K. Hagensen, J.F. Bentzon, and E. Falk From vulnerable plaque to atherothrombosis J Intern Med 263 2008 506 516
4. J.C. Sluimer, and M.J. Daemen Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis J Pathol 218 2009 7 29
5. W.E. Hellings, W. Peeters, and F.L. Moll et al. Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study Circulation 121 2010 1941 1950
6. D. Ribatti, F. Levi-Schaffer, and P.T. Kovanen Inflammatory angiogenesis in atherogenesis - a double-edged sword Ann Med 40 2008 606 621
7. M. Jeziorska, and D.E. Woolley Local neovascularization and cellular composition within vulnerable regions of atherosclerotic plaques of human carotid arteries J Pathol 188 1999 189 196
8. O.J. de Boer, A.C. van der Wal, P. Teeling, and A.E. Becker Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization Cardiovasc Res 41 1999 443 449
9. A. Tawakol, R.Q. Migrino, and G.G. Bashian et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients J Am Coll Cardiol 48 2006 1818 1824
10. J.H. Rudd, K.S. Myers, and S. Bansilal et al. (18)Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: implications for atherosclerosis therapy trials J Am Coll Cardiol 50 2007 892 896
11. G.L. Ten Kate, S.C. van den Oord, and E.J. Sijbrands et al. Current status and future developments of contrast-enhanced ultrasound of carotid atherosclerosis J Vasc Surg 57 2013 539 546
12. S. Coli, M. Magnoni, and G. Sangiorgi et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity J Am Coll Cardiol 52 2008 223 230
13. M.F. Giannoni, E. Vicenzini, and M. Citone et al. Contrast carotid ultrasound for the detection of unstable plaques with neoangiogenesis: a pilot study Eur J Vasc Endovasc Surg 37 2009 722 727
14. A. Hoogi, D. Adam, A. Hoffman, H. Kerner, S. Reisner, and D. Gaitini Carotid plaque vulnerability: quantification of neovascularization on contrast-enhanced ultrasound with histopathologic correlation AJR Am J Roentgenol 196 2011 431 436
15. F. Shah, P. Balan, and M. Weinberg et al. Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis Vasc Med 12 2007 291 297
16. O. Hjelmgren, P. Holdfeldt, and L. Johansson et al. Identification of vascularised carotid plaques using a standardised and reproducible technique to measure ultrasound contrast uptake Eur J Vasc Endovasc Surg 46 2013 21 28
17. L. Bokemark, J. Wikstrand, H. Wedel, and B. Fagerberg Insulin, insulin propeptides and intima-media thickness in the carotid artery in 58-year-old clinically healthy men. The Atherosclerosis and Insulin Resistance study (AIR) Diabet Med 19 2002 144 151
18. U. Prahl, P. Holdfeldt, G. Bergstrom, B. Fagerberg, J. Hulthe, and T. Gustavsson Percentage white: a new feature for ultrasound classification of plaque echogenicity in carotid artery atherosclerosis Ultrasound Med Biol 36 2010 218 226
19. L.J. Menezes, C.W. Kotze, and O. Agu et al. Investigating vulnerable atheroma using combined (18)F-FDG PET/CT angiography of carotid plaque with immunohistochemical validation J Nucl Med 52 2011 1698 1703
20. E.J. Folco, Y. Sheikine, and V.Z. Rocha et al. Hypoxia but not inflammation augments glucose uptake in human macrophages: implications for imaging atherosclerosis with (18)fluorine-labeled 2-deoxy-d-glucose positron emission tomography J Am Coll Cardiol 58 2011 603 614
21. J.H. Rudd, E.A. Warburton, and T.D. Fryer et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography Circulation 105 2002 2708 2711
22. S.S. Silvera, H.E. Aidi, and J.H. Rudd et al. Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET/CT and MRI in carotid and femoral arteries Atherosclerosis 207 2009 139 143
23. M. Graebe, L. Borgwardt, L. Hojgaard, H. Sillesen, and A. Kjaer When to image carotid plaque inflammation with FDG PET/CT Nucl Med Commun 31 2010 773 779
24. S.F. Pedersen, M. Graebe, A.M. Hag, L. Hoejgaard, H. Sillesen, and A. Kjaer Microvessel density but not neoangiogenesis is associated with 18F-FDG uptake in human atherosclerotic carotid plaques Mol Imag. Biol 14 2012 384 392 (MIB: the official publication of the Academy of Molecular Imaging)
25. J.R. Davies, J.H. Rudd, and T.D. Fryer et al. Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging Stroke 36 2005 2642 2647
26. N. Tahara, H. Kai, and M. Ishibashi et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography J Am Coll Cardiol 48 2006 1825 1831
27. F.R. Joshi, A.C. Lindsay, D.R. Obaid, E. Falk, and J.H. Rudd Non-invasive imaging of atherosclerosis Eur Heart J Cardiovasc Imaging 13 2012 205 218