The cost-effectiveness ratio of a managed protocol for severe sepsis

Journal of Critical Care

Volumn 29, Issue 4, 2014, Pages 692.e1-692.e6

  Assuncao, Murillo Santucci Cesar ^a   Teich, Vanessa ^b   Shiramizo, Sandra Christina Pereira Lima ^a   Araújo, Denizart Vianna ^c   Carrera, Renato Melli ^a   Serpa Neto, Ary ^a   Silva, Eliezer ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^b MedInsight   (Brazil)

^c STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cost effectiveness analysis; Outcome; Protocol; Sepsis; Septic shock; Severe sepsis

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL PROTOCOL; COHORT ANALYSIS; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; DISEASE SEVERITY; FEMALE; FLUID RESUSCITATION; HEALTH CARE DELIVERY; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HOSPITALIZATION COST; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; LIFE EXPECTANCY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PROSPECTIVE STUDY; RISK REDUCTION; SEPSIS; SEPTIC SHOCK; APACHE; BRAZIL; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; COST BENEFIT ANALYSIS; ECONOMICS; EPIDEMIOLOGY; HOSPITALIZATION; INTENSIVE CARE; MIDDLE AGED; NONPARAMETRIC TEST; SHOCK, SEPTIC;

AGED; APACHE; BRAZIL; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CLINICAL PROTOCOLS; CONTROLLED BEFORE-AFTER STUDIES; COST-BENEFIT ANALYSIS; FEMALE; HOSPITALIZATION; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC; STATISTICS, NONPARAMETRIC;

EID: 84902238950     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2014.03.008     Document Type: Article

References (26)

1. Silva E., Pedro Mde A., Sogayar A.C., et al. Brazilian Sepsis Epidemiological Study (BASES study). Crit Care 2004, 8:R251-R260.
2. Sogayar A.M., Machado F.R., Rea-Neto A., et al. A multicentre, prospective study to evaluate costs of septic patients in Brazilian intensive care units. Pharmacoeconomics 2008, 26:425-434.
3. Ferrer R., Artigas A., Levy M.M., et al. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 2008, 299:2294-2303.
4. Assuncao M., Akamine N., Cardoso G.S., et al. Survey on physicians' knowledge of sepsis: do they recognize it promptly?. J Crit Care 2010, 25:545-552.
5. Westphal G.A., Koenig A., Caldeira Filho M., et al. Reduced mortality after the implementation of a protocol for the early detection of severe sepsis. J Crit Care 2011, 26:76-81.
6. Gao F., Melody T., Daniels D.F., et al. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care 2005, 9:R764-R770.
7. Nguyen H.B., Corbett S.W., Steele R., et al. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007, 35:1105-1112.
8. Castellanos-Ortega A., Suberviola B., Garcia-Astudillo L.A., et al. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med 2010, 38:1036-1043.
9. Suarez D., Ferrer R., Artigas A., et al. Cost-effectiveness of the Surviving Sepsis Campaign protocol for severe sepsis: a prospective nation-wide study in Spain. Intensive Care Med 2011, 37:444-452.
10. Jones A.E., Troyer J.L., Kline J.A. Cost-effectiveness of an emergency department-based early sepsis resuscitation protocol. Crit Care Med 2011, 1:1306-1312.
11. Talmor D., Greenberg D., Howell M.D., et al. The costs and cost-effectiveness of an integrated sepsis treatment protocol. Crit Care Med 2008, 36:1168-1174.
12. Shorr A.F., Micek S.T., Jackson W.L., et al. Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs?. Crit Care Med 2007, 35:1257-1262.
13. Pereira A.J., Fernandes C.J., Sousa A.G., et al. Improving performance and outcome (mortality) after implementation of a change-bundle approach for management of septic patients. Einstein 2008, 6:395-401.
14. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655.
15. Knaus W.A., Draper E.A., Wagner D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829.
16. Brasindice price index: Brasindice price index [Andrei Publicações Médicas, Farmacêuticas e Técnicas Ltda]. http://www.brasindice.com.br.
17. Fundação Instituto de Pesquisas EconÔmicas [Fipe é uma entidade de direito privado, sem fins lucrativos, criada em 1973 para apoiar o Departamento de Economia da Faculdade de Economia, Administração e Contabilidade da Universidade de São Paulo (FEA-USP), com destacada atuação nas áreas de pesquisa e ensino., p site]. http://www.fipe.org.br/web/index.asp.
18. Coughlin M.T., Angus D.C. Economic evaluation of new therapies in critical illness. Crit Care Med 2003, 31:S7-S16.
19. Instituto Brasileiro de Geografia e Estatística, http://www.ibge.gov.br/.
20. Ferrer R., Artigas A., Suarez D., et al. Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med 2009, 180:861-866.
21. Kumar A., Roberts D., Wood K.E., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*. Crit Care Med 2006, 34:1589-1596.
22. Levy M.M., Dellinger R.P., Townsend S.R., et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis*. Crit Care Med 2010, 38:367-374.
23. Shorr A.F., Susla G.M., Kollef M.H. Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin*. Crit Care Med 2004, 137-143.
24. Micek S.T., Roubinian N., Heuring T., et al. Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 2006, 34:2707-2713.
25. Guzauskas G.F., Boudreau D.M., Villa K.F., et al. The cost-effectiveness of primary stroke centers for acute stroke care. Stroke 2012, 43:1617-1623.
26. Awissi D.K., Begin C., Moisan J., et al. I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluation. Ann Pharmacother 2012, 46:21-28.