Causes of early stent thrombosis in patients presenting with acute coronary syndrome: An ex vivo human autopsy study

Journal of the American College of Cardiology

Volumn 63, Issue 23, 2014, Pages 2510-2520

  Nakano, Masataka ^a   Yahagi, Kazuyuki ^a   Otsuka, Fumiyuki ^a   Sakakura, Kenichi ^a   Finn, Aloke V ^b   Kutys, Robert ^a   Ladich, Elena ^a   Fowler, David R ^c   Joner, Michael ^a   Virmani, Renu ^a  

^a CVPATH INSTITUTE   (United States)

^b EMORY UNIVERSITY HOSPITAL   (United States)

^c OFFICE OF THE CHIEF MEDICAL EXAMINER   (United States)

Author keywords

acute coronary syndrome(s); bare metal stent(s); drug eluting stent(s); early stent thrombosis; histopathology

Indexed keywords

ACUTE CORONARY SYNDROME; AGED; ARTICLE; AUTOPSY; BARE METAL STENT; CAUSE OF DEATH; CONTROLLED STUDY; DRUG ELUTING STENT; FEMALE; HEART MUSCLE ISCHEMIA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; METAL IMPLANTATION; MICROSCOPY; MORPHOMETRICS; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; CORONARY THROMBOSIS; ENDOSCOPIC ECHOGRAPHY; EPIDEMIOLOGY; FOLLOW UP; MORTALITY; PATHOLOGY; PROSTHESIS FAILURE; RETROSPECTIVE STUDY; SURVIVAL RATE; TIME; TRENDS; UNITED STATES; CARDIOVASCULAR MORTALITY; CLINICAL FEATURE; HEART MUSCLE NECROSIS; INCIDENCE; INCOMPLETE APPOSITION AREA; INCOMPLETE APPOSITION DISTANCE; MEDIAL TEAR ARC; MEDIAL TEAR LENGTH; NECROTIC CORE AREA; NECROTIC CORE PROLAPSE; STRUT ASSOCIATED WITH MEDIAL TEAR PER SECTION; STRUT PENETRATING INTO NECROTIC CORE PER SECTION; STRUT PENETRATION DEPTH INTO NECROTIC CORE;

IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN;

ACUTE CORONARY SYNDROME; AGED; AUTOPSY; CAUSE OF DEATH; CORONARY THROMBOSIS; DRUG-ELUTING STENTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; PERCUTANEOUS CORONARY INTERVENTION; PROSTHESIS FAILURE; RETROSPECTIVE STUDIES; SIROLIMUS; SURVIVAL RATE; TIME FACTORS; ULTRASONOGRAPHY, INTERVENTIONAL; UNITED STATES;

EID: 84902215252     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.02.607     Document Type: Article

References (36)

1. H. Jneid, J.L. Anderson, and R.S. Wright et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 60 2012 645 681
2. P.T. O'Gara, F.G. Kushner, and D.D. Ascheim et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 61 2013 e78 e140
3. C.W. Hamm, J.P. Bassand, and S. Agewall et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC) Eur Heart J 32 2011 2999 3054
4. P.G. Steg, S.K. James, and D. Atar et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Eur Heart J 33 2012 2569 2619
5. N. Kukreja, Y. Onuma, H.M. Garcia-Garcia, J. Daemen, R. van Domburg, and P.W. Serruys The risk of stent thrombosis in patients with acute coronary syndromes treated with bare-metal and drug-eluting stents J Am Coll Cardiol Intv 2 2009 534 541
6. A.T. Ong, A. Hoye, and J. Aoki et al. Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation J Am Coll Cardiol 45 2005 947 953
7. F. Alfonso, A. Suarez, and D.J. Angiolillo et al. Findings of intravascular ultrasound during acute stent thrombosis Heart 90 2004 1455 1459
8. J. Aoki, A.J. Lansky, and R. Mehran et al. Early stent thrombosis in patients with acute coronary syndromes treated with drug-eluting and bare metal stents: the Acute Catheterization and Urgent Intervention Triage Strategy trial Circulation 119 2009 687 698
9. G.D. Dangas, B.E. Claessen, and R. Mehran et al. Development and validation of a stent thrombosis risk score in patients with acute coronary syndromes J Am Coll Cardiol Intv 5 2012 1097 1105
10. A.V. Finn, M. Joner, and G. Nakazawa et al. Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization Circulation 115 2007 2435 2441
11. M. Joner, A.V. Finn, and A. Farb et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk J Am Coll Cardiol 48 2006 193 202
12. A. Farb, A.L. Tang, A.P. Burke, L. Sessums, Y. Liang, and R. Virmani Sudden coronary death. Frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction Circulation 92 1995 1701 1709
13. R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions Arterioscler Thromb Vasc Biol 20 2000 1262 1275
14. Faraway JJ. Mixed effect models for nonnormal responses. In: Faraway JJ, editor. Extending the Linear Model with R: Generalized Linear, Mixed Effects and Nonparametric Regression Models. Boca Raton, FL: Chapman and Hall/CRC, 2005:201-10.
15. I. Porto, L. Di Vito, and F. Burzotta et al. Predictors of periprocedural (type IVa) myocardial infarction, as assessed by frequency-domain optical coherence tomography Circ Cardiovasc Interv 5 2012 89 96 S1-6
16. A. Fernandez-Ortiz, J.J. Badimon, and E. Falk et al. Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture J Am Coll Cardiol 23 1994 1562 1569
17. S.Y. Choi, B. Witzenbichler, and A. Maehara et al. Intravascular ultrasound findings of early stent thrombosis after primary percutaneous intervention in acute myocardial infarction: a Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) substudy Circ Cardiovasc Interv 4 2011 239 247
18. E. Cheneau, L. Leborgne, and G.S. Mintz et al. Predictors of subacute stent thrombosis: results of a systematic intravascular ultrasound study Circulation 108 2003 43 47
19. J.W. van Werkum, A.A. Heestermans, and A.C. Zomer et al. Predictors of coronary stent thrombosis: the Dutch Stent Thrombosis Registry J Am Coll Cardiol 53 2009 1399 1409
20. V. Toschi, R. Gallo, and M. Lettino et al. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques Circulation 95 1997 594 599
21. J.N. Wilcox, K.M. Smith, S.M. Schwartz, and D. Gordon Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque Proc Natl Acad Sci U S A 86 1989 2839 2843
22. J.D. Marmur, M. Rossikhina, and A. Guha et al. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury J Clin Invest 91 1993 2253 2259
23. A.B. Baker, W.J. Gibson, and V.B. Kolachalama et al. Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance J Am Coll Cardiol 59 2012 1551 1560
24. A.D. Schecter, P.L. Giesen, and O. Taby et al. Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation J Clin Invest 100 1997 2276 2285
25. R. Kranzhofer, S.K. Clinton, K. Ishii, S.R. Coughlin, J.W. Fenton 2nd, and P. Libby Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes Circ Res 79 1996 286 294
26. H. Loppnow, and P. Libby Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6 J Clin Invest 85 1990 731 738
27. G. De Luca, M.T. Dirksen, and C. Spaulding et al. Time course, predictors and clinical implications of stent thrombosis following primary angioplasty. Insights from the DESERT cooperation Thromb Haemost 110 2013 826 833
28. Y.J. Hong, M.H. Jeong, and Y.H. Choi et al. Clinical, angiographic, and intravascular ultrasound predictors of early stent thrombosis in patients with acute myocardial infarction Int J Cardiol 168 2013 1674 1675
29. K. Fujii, S.G. Carlier, and G.S. Mintz et al. Stent underexpansion and residual reference segment stenosis are related to stent thrombosis after sirolimus-eluting stent implantation: an intravascular ultrasound study J Am Coll Cardiol 45 2005 995 998
30. J. Legutko, J. Jakala, and G.S. Mintz et al. Virtual histology- intravascular ultrasound assessment of lesion coverage after angiographically-guided stent implantation in patients with ST elevation myocardial infarction undergoing primary percutaneous coronary intervention Am J Cardiol 109 2012 1405 1410
31. R. Sakhuja, W.M. Suh, F.A. Jaffer, and I.K. Jang Residual thrombogenic substrate after rupture of a lipid-rich plaque: possible mechanism of acute stent thrombosis? Circulation 122 2010 2349 2350
32. N.G. Uren, S.P. Schwarzacher, and J.A. Metz et al. Predictors and outcomes of stent thrombosis: an intravascular ultrasound registry Eur Heart J 23 2002 124 132
33. J. Gomez-Lara, M. Radu, and S. Brugaletta et al. Serial analysis of the malapposed and uncovered struts of the new generation of everolimus-eluting bioresorbable scaffold with optical coherence tomography J Am Coll Cardiol Intv 4 2011 992 1001
34. K. Kolandaivelu, R. Swaminathan, and W.J. Gibson et al. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings Circulation 123 2011 1400 1409
35. T. Okabe, G.S. Mintz, and A.N. Buch et al. Intravascular ultrasound parameters associated with stent thrombosis after drug-eluting stent deployment Am J Cardiol 100 2007 615 620
36. R.J. Siegel, K. Swan, G. Edwalds, and M.C. Fishbein Limitations of postmortem assessment of human coronary artery size and luminal narrowing: differential effects of tissue fixation and processing on vessels with different degrees of atherosclerosis J Am Coll Cardiol 5 1985 342 346