Protease-mediated ectodomain shedding

Thorax

Volumn 69, Issue 7, 2014, Pages 682-684

  Clark, Peter ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM PROTEIN; GROWTH FACTOR; MATRIX METALLOPROTEINASE; PROTEINASE; SECRETASE; SHEDDASE; UNCLASSIFIED DRUG;

ARTICLE; ASTHMA; CARBOXY TERMINAL SEQUENCE; ECTODOMAIN SHEDDING; EMPHYSEMA; ENZYME ACTIVITY; HUMAN; LUNG DEVELOPMENT; LUNG EMPHYSEMA; LUNG FIBROSIS; LUNG INFECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; REGULATORY MECHANISM;

ADAMS; EMPHYSEMA; MATRIX METALLOPROTEINASE; SECRETASE; SHEDDASE;

ADAM PROTEINS; ANIMALS; APOPTOSIS; HUMANS; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PROTEOLYSIS; PULMONARY EMPHYSEMA;

EID: 84902206460     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2013-204403     Document Type: Article

References (6)

1. Hayashida K, Bartlett AH, Chen Y, et al. Molecular and cellular mechanisms of ectodomain shedding. Anat Rec (Hoboken) 2010;293:925 -37.
2. Weber S, Saftig P. Ectodomain shedding and ADAMs in development. Development 2012;139:3693-709.
3. Mimae T, Hagiyama M, Inoue T, et al. Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema. Thorax 2014;69:223-31.
4. Chow FL, Fernandez-Patron C. Many membrane proteins undergo ectodomain shedding by proteolytic cleavage. Does one sheddase do the job on all of these proteins? IUBMB Life 2007;59:44-7.
5. Higashiyama S, Nanba D, Nakayama H, et al. Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands. J Biochem 2011;150:15-22.
6. Hartmann M, Herrlich A, Herrlich P. Who decides when to cleave an ectodomain? Trends Biochem Sci 2013;38:111-20.