Contribution of anti-β2glycoprotein I IgA antibodies to the diagnosis of anti-phospholipid syndrome: Potential interest of target domains to discriminate thrombotic and non-thrombotic patients

Rheumatology (United Kingdom)

Volumn 53, Issue 7, 2014, Pages 1215-1218

  Despierres, Laura ^a   Beziane, Abdou ^a   Kaplanski, Gilles ^a   Granel, Brigitte ^a   Serratrice, Jacques ^a   Cohen, William ^a   Bretelle, Florence ^a   Rossi, Pascal ^a   Morange, Pierre Emmanuel ^a   Weiller, Pierre Jean ^a   Harlé, Jean Robert ^a   Bongrand, Pierre ^a   Bardin, Nathalie ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Anti cardiolipin antibodies IgA; Anti phospholipid syndrome; Domain of ab GPI antibodies

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN A;

ADULT; ANTIBODY DETECTION; ANTIBODY STRUCTURE; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; D1 DOMAIN; D4 DOMAIN; D5 DOMAIN; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREVALENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RETROSPECTIVE STUDY; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOSIS;

ANTI-CARDIOLIPIN ANTIBODIES IGA; ANTI-PHOSPHOLIPID SYNDROME; ANTI-Β2GLYCOPROTEIN I ANTIBODIES IGA; DOMAIN OF AΒ2GPI ANTIBODIES;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; BIOLOGICAL MARKERS; COHORT STUDIES; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN A; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOSIS;

EID: 84902176295     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu003     Document Type: Article

References (14)

1. Miyakis S, Lockshin MD, Atsumi T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306.
2. 2glycoprotein I testing: report from the 13th International Congress on Antiphospholipid Antibodies. Arthritis Rheum 2012; 64: 1-10.
3. Samarkos M, Asherson RA, Loizou S. The clinical significance of IgA antiphospholipid antibodies. J Rheumatol 2001; 28: 694-7.
4. Akhter E, Shums Z, Norman GL et al. Utility of antiphosphatidylserine/prothrombin and IgA antiphospholipid assays in systemic lupus erythematosus. J Rheumatol 2013; 40: 282-6.
5. 2glycoprotein I antibodies as risk factors for acute myocardial infarction. Arq Bras Cardiol 2004; 83: 137-40.
6. De Laat B, Derksen RH, Urbanus RT et al. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005;15;105:1540-5.
7. Andreoli L, Nalli C, Motta M et al. Anti-2-glycoprotein I IgG antibodies from 1-year-old healthy children born to mothers with systemic autoimmune diseases preferentially target domain 4/5: might it be the reason for their innocent profile? Ann Rheum Dis 2011;70:380.
8. Sanmarco M, Bardin N, Camoin L et al. Antigenic profile, prevalence, and clinical significance of antiphospholipid antibodies in women referred for in vitro fertilization. Ann N Y Acad Sci 2007; 1108: 457-65.
9. Bertolaccini ML, Atsumi T, Escudero Contreras A et al. The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus. J Rheumatol 2001; 28: 2637-43.
10. Mehrani T, Petri M. Association of IgA Anti-beta2 glycoprotein I with clinical and laboratory manifestations of systemic lupus erythematosus. J Rheumatol 2011; 38: 64-8.
11. Sweiss NJ, Bo R, Kapadia R et al. IgA anti-beta2- glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus. PLoS One 2010;19;5:e12280.
12. Serrano A, Garci{dotless}́a F, Serrano M et al. IgA antibodies against b2 glycoprotein I in hemodialysis patients are an independent risk factor for mortality. Kidney Int 2012; 81: 1239-44.
13. Blank M, Asherson RA, Cervera R et al. Antiphospholipid syndrome infectious origin. J Clin Immunol 2004; 24: 12-23.
14. De Groot PG, Urbanus RT. The significance of autoantibodies against b2-glycoprotein I. Blood 2012; 120: 266-74.