Codon 104 of p53 is not an adaptively selected site for extreme environments in mammals of the Tibet plateau

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 23, 2014, Pages

  Liu, Zhen ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALTITUDE ACCLIMATIZATION; CHINA; CODON; ENVIRONMENTAL STRESS; EVOLUTIONARY ADAPTATION; GENE MUTATION; LETTER; MAMMAL; MICROTUS OCHROGASTER; MICROTUS OECONOMUS; MOLECULAR EVOLUTION; MYOSPALAX BAILEYI; NONHUMAN; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; APOPTOSIS; ARVICOLINAE; COLD TEMPERATURE; EVOLUTION, MOLECULAR; HUMANS; STRESS, PHYSIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84902174877     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323662111     Document Type: Letter

References (5)

1. Zhao Y, et al. (2013) Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau. Proc Natl Acad Sci USA 110(51):20639-20644.
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4. Kimura M, Ohta T (1974) On some principles governing molecular evolution. Proc Natl Acad Sci USA 71(7):2848-2852.
5. Thomas JW, et al. (2003) Comparative analyses of multi-species sequences from targeted genomic regions. Nature 424(6950):788-793. (Pubitemid 37021709)