Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration

Journal of Biological Chemistry

Volumn 289, Issue 23, 2014, Pages 16349-16361

  Krueger, Aaron B ^a   Drasin, David J ^a   Lea, Wendy A ^b   Patrick, Aaron N ^a   Patnaik, Samarjit ^b   Backos, Donald S ^c   Matheson, Christopher J ^c   Hu, Xin ^b   Barnaeva, Elena ^b   Holliday, Michael J ^a   Blevins, Melanie A ^a   Robin, Tyler P ^a   Eisenmesser, Elan Z ^a   Ferrer, Marc ^b   Simeonov, Anton ^b   Southall, Noel ^b   Reigan, Philip ^c   Marugan, Juan ^b   Ford, Heide L ^a   Zhao, Rui ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; DISEASES; SILICON; TRANSCRIPTION;

ALLOSTERIC INHIBITOR; ANTICANCER DRUG; APOPTOSIS PATHWAYS; BREAST CANCER CELLS; CHEMICAL PROBES; HALOACID DEHALOGENASE; PHOSPHATASE ACTIVITY; TYROSINE PHOSPHATASE;

PHOSPHATASES;

MAGNESIUM ION; MLS 000544460; PHOSPHATASE; PROTEIN EYA2; PROTEIN EYA3; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CELL MIGRATION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEQUENCE ALIGNMENT;

ANTICANCER DRUG; ENZYME INHIBITOR; MIGRATION; PHOSPHATASE; TRANSCRIPTION COACTIVATOR;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CALORIMETRY; CELL LINE; CELL MOVEMENT; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNESIUM; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASES; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84902171852     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.566729     Document Type: Article

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