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Volumn 3, Issue 1, 2013, Pages 156-159

Developing treatments for pulmonary arterial hypertension

Author keywords

Drug development; Drug targets; Early phase clinical trials; Pulmonary hypertension

Indexed keywords


EID: 84902161742     PISSN: 20458932     EISSN: 20458940     Source Type: Journal    
DOI: 10.4103/2045-8932.109961     Document Type: Article
Times cited : (6)

References (18)
  • 2
    • 79955601786 scopus 로고    scopus 로고
    • Trial watch: Phase II failures: 2008-2010
    • Arrowsmith J. Trial watch: Phase II failures: 2008-2010. Nat Rev Drug Discov 2011;10:328-9.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 328-329
    • Arrowsmith, J.1
  • 4
    • 71949129187 scopus 로고    scopus 로고
    • Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure
    • Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF. Animal models of pulmonary arterial hypertension: The hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 2009;297: L1013-32.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , pp. L1013-L1032
    • Stenmark, K.R.1    Meyrick, B.2    Galie, N.3    Mooi, W.J.4    McMurtry, I.F.5
  • 5
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • International PPH Consortium
    • International PPH Consortium, Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA 3rd, et al. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet 2000;26:81-4.
    • (2000) Nat Genet , vol.26 , pp. 81-84
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3    Thomson, J.R.4    Phillips, J.A.5
  • 6
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (Gene PPH 1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, et al. Familial primary pulmonary hypertension (gene PPH 1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 2000; 67:737-44.
    • (2000) Am J Hum Genet , vol.67 , pp. 737-744
    • Deng, Z.1    Morse, J.H.2    Slager, S.L.3    Cuervo, N.4    Moore, K.J.5    Venetos, G.6
  • 7
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, et al. Survival in patients with idiopathic, familial and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 2010;122:156-63.
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3    Bertocchi, M.4    Habib, G.5    Gressin, V.6
  • 8
    • 77956684064 scopus 로고    scopus 로고
    • Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension
    • Girerd B, Montani D, Eyries M, Yaici A, Sztrymf B, Coulet F, et al. Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension. Respir Res 2010;11:73.
    • (2010) Respir Res , vol.11 , pp. 73
    • Girerd, B.1    Montani, D.2    Eyries, M.3    Yaici, A.4    Sztrymf, B.5    Coulet, F.6
  • 9
    • 77955069395 scopus 로고    scopus 로고
    • Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension
    • Austin ED, Phillips JA, Cogan JD, Hamid R, Yu C, Stanton KC, et al. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir Res 2009; 10:87.
    • (2009) Respir Res , vol.10 , pp. 87
    • Austin, E.D.1    Phillips, J.A.2    Cogan, J.D.3    Hamid, R.4    Yu, C.5    Stanton, K.C.6
  • 10
    • 59649097082 scopus 로고    scopus 로고
    • Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline
    • Thomas M, Docx C, Holmes AM, Beach S, Duggan N, England K, et al. Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol 2009; 174:380-9.
    • (2009) Am J Pathol , vol.174 , pp. 380-389
    • Thomas, M.1    Docx, C.2    Holmes, A.M.3    Beach, S.4    Duggan, N.5    England, K.6
  • 11
    • 74549185752 scopus 로고    scopus 로고
    • Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    • Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, et al. Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation 2010;121:52-62.
    • (2010) Circulation , vol.121 , pp. 52-62
    • Sofat, R.1    Hingorani, A.D.2    Smeeth, L.3    Humphries, S.E.4    Talmud, P.J.5    Cooper, J.6
  • 12
    • 79960031695 scopus 로고    scopus 로고
    • Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension clinical prevalence, outcomes and mechanistic insights
    • Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JS, et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension clinical prevalence, outcomes and mechanistic insights. J Am Coll Cardiol 2011;58:300-9.
    • (2011) J am Coll Cardiol , vol.58 , pp. 300-309
    • Rhodes, C.J.1    Howard, L.S.2    Busbridge, M.3    Ashby, D.4    Kondili, E.5    Gibbs, J.S.6
  • 13
    • 79951850287 scopus 로고    scopus 로고
    • Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: A randomised controlled trial
    • Abraham WT, Adamson PB, Bourge RC, Aaron MF, Costanzo MR, Stevenson LW, et al. Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: A randomised controlled trial. Lancet 2011;377:658-66.
    • (2011) Lancet , vol.377 , pp. 658-666
    • Abraham, W.T.1    Adamson, P.B.2    Bourge, R.C.3    Aaron, M.F.4    Costanzo, M.R.5    Stevenson, L.W.6
  • 15
    • 84858180382 scopus 로고    scopus 로고
    • Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension
    • Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, et al. Lung ¹⁸F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med 2012;185:670-9.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 670-679
    • Marsboom, G.1    Wietholt, C.2    Haney, C.R.3    Toth, P.T.4    Ryan, J.J.5    Morrow, E.6
  • 16
    • 36249016380 scopus 로고    scopus 로고
    • Flexible design and efficient implementation of adaptive dose-finding studies
    • Weir CJ, Spiegelhalter DJ, Grieve AP. Flexible design and efficient implementation of adaptive dose-finding studies. J Biopharm Stat 2007;17:1033-50.
    • (2007) J Biopharm Stat , vol.17 , pp. 1033-1050
    • Weir, C.J.1    Spiegelhalter, D.J.2    Grieve, A.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.