Gadoxetic acid-enhanced MRI for hepatocellular carcinoma and hypointense nodule observed in the hepatobiliary phase

Radiologia Medica

Volumn 119, Issue 6, 2014, Pages 367-376

  Iannicelli, Elsa ^a,b   Di Pietropaolo, Marco ^a,b   Marignani, Massimo ^a,b   Briani, Chiara ^a,b   Federici, Giulia Francesca ^a,b   Fave, Gianfranco Delle ^a,b   David, Vincenzo ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Early hepatocellular carcinoma; Gadoxetic acid; Hepatic cirrhosis; Hepatocellular carcinoma; Magnetic resonance imaging

Indexed keywords

CONTRAST MEDIUM; DIAGNOSTIC AGENT; GADOLINIUM PENTETATE; GADOXETIC ACID;

AGED; ARTICLE; COMPUTER ASSISTED DIAGNOSIS; DIFFERENTIAL DIAGNOSIS; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PRECANCER; RETROSPECTIVE STUDY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; GADOLINIUM DTPA; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; RETROSPECTIVE STUDIES;

EID: 84902152275     PISSN: 00338362     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11547-013-0364-x     Document Type: Article

References (29)

1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108 (Pubitemid 40372904)
2. Kobayashi M, Ikeda K, Hosaka T et al (2006) Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis. Cancer 106:636-647 (Pubitemid 43157628)
3. Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 53:1020-1022
4. Motosugi U, Ichikawa T, Sano K et al (2011) Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease. J Magn Reson Imaging 34:88-94
5. Kudo M (2010) Will Gd-EOB-MRI change the diagnostic algorithm in hepatocellular carcinoma? Oncology 78(Suppl 1):87-93
6. Huppertz A, Balzer T, Blakeborough A et al (2004) Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 230:266-275 (Pubitemid 37549812)
7. Mazzaferro V, Regalia E, Doci R et al (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693-699 (Pubitemid 26079803)
8. El-Serag HB, Marrero JA, Rudolph L et al (2008) Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 134:1752-1763 (Pubitemid 351615415)
9. Van Beers BE, Pastor CM, Hussain HK (2012) Primovist, Eovist: what to expect? J Hepatol 57:421-429
10. Saito K, Araki Y, Park J et al (2010) Effect of Gd-EOB-DTPA on T2-weighted and diffusion-weighted images for the diagnosis of hepatocellular carcinoma. J Magn Reson Imaging 32:229-234
11. Goodwin MD, Dobson JE, Sirlin CB et al (2011) Diagnostic challenges and pitfalls in MR imaging with hepatocyte specific contrast agents. Radiographics 31:1547-1568
12. Frydrychowicz A, Lubner MG, Brown JJ et al (2012) Hepatobiliary MR imaging with gadolinium-based contrast agents. J Magn Reson Imaging 35:492-511
13. Ahn SS, Kim MJ, Lim JS (2010) Added value of gadoxetic acid-enhanced hepatobiliary phase MR imaging in the diagnosis of hepatocellular carcinoma. Radiology 255:459-466
14. Van den Bos IC, Hussain SM, Dwarkasing RS et al (2007) MR imaging of hepatocellular carcinoma: relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. J Magn Reson Imaging 26:1548-1555 (Pubitemid 350291283)
15. Hayashida M, Ito K, Fujita T et al (2008) Small hepatocellular carcinomas in cirrhosis: differences in contrast enhancement effects between helical CT and MR imaging during multiphasic dynamic imaging. Magn Reson Imaging 26:65-71 (Pubitemid 350299721)
16. Narita M, Hatano E, Arizono S et al (2009) Expression of AOTP1B3 determines uptake of Gd-EOB- DTPA in hepatocellular carcinoma. J Gastroenterol 44:793-798
17. Suh YJ, Kim MJ, Choi JY et al (2011) Differentiation of hepatic hyperintense lesions seen on gadoxetic acid-enhanced hepatobiliary phase MRI. AJR Am J Roentgenol 197:W44-W52
18. Golfieri R, Renzulli M, Lucidi V et al (2011) Contribution of the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to dynamic MRI in the detection of hypovascular small (≥2 cm) HCC in cirrhosis. Eur Radiol 21:1233-1242
19. Tajima T, Honda H, Taguchi K et al (2002) Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodules: CT angiography and pathologic correlation. AJR Am J Roentgenol 178:885-897 (Pubitemid 34250225)
20. Kogita S, Imai Y, Okada M et al (2010) Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol 20:2405-2413
21. Golfieri R, Grazioli L, Orlando E et al (2012) Which is the best MRI marker of malignancy for atypical cirrhotic nodules: hypointensity in hepatobiliary phase alone or combined with other features? Classification after Gd-EOB-DTPA administration. J Magn Reson Imaging 36:648-657
22. Park YN (2011) Update on precursor and early lesions of hepatocellular carcinomas. Arch Pathol Lab Med 135:704-715
23. Chanyaputhipong J, Low SC, Chow PK (2011) Gadoxetate acid-enhanced MR imaging for HCC: a review for clinicians. Int J Hepatol 2011:489342
24. Akai H, Matsuda I, Kiryu S (2012) Fate of hypointense lesions on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Eur J Radiol 81:2973-2977
25. Sano K, Ichikawa T, Motosugi U (2011) Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging. Radiology 261:834-844
26. Kumada T, Toyoda H, Tada T et al (2011) Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI. AJR Am J Roentgenol 197:58-63
27. Battaglia V, Bozzi E, Zingoni G et al (2010) Correlation between histologic diagnosis and MR signal intensity after Gd-EOB-DTPA administration of nodules detected within cirrhotic explanted livers: retrospective analysis. Eur Radiol 20(suppl. 1):1-70
28. Lee JM, Zech CJ, Bolondi L et al (2011) Consensus report of the 4th international forum for gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging. Korean J Radiol 12:403-415
29. Kudo M, Izumi N, Kokudo N et al (2011) Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis 29:339-364