Long-term renal and neurologic outcomes among survivors of diethylene glycol poisoning

JAMA Internal Medicine

Volumn 174, Issue 6, 2014, Pages 912-917

  Conklin, Laura ^a   Sejvar, James J ^b   Kieszak, Stephanie ^a   Sabogal, Raquel ^a   Sanchez, Carlos ^a   Flanders, Dana ^a   Tulloch, Felicia ^c   Victoria, Gerardo ^c   Rodriguez, Giselle ^d   Sosa, Nestor ^e   McGeehin, Michael A ^a   Schier, Joshua G ^a,f  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^c Santo Tomas Hospital   (Panama)

^d Caja de Seguro Social ^*  (Panama)

^e Gorgas Memorial Institute   (Panama)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DIETHYLENE GLYCOL;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; ALCOHOL INTOXICATION; ARTICLE; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DISEASE EXACERBATION; END STAGE RENAL DISEASE; EVALUATION STUDY; FACIAL NERVE; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HOSPITALIZATION; HUMAN; INGESTION; KIDNEY DISEASE; KIDNEY FUNCTION; LONGITUDINAL STUDY; MALE; MOTOR PERFORMANCE; NERVE CONDUCTION; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; SELF REPORT; SURVIVOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DRUG CONTAMINATION; ETHYLENE GLYCOLS; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; PANAMA; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84902137064     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2014.344     Document Type: Article

References (13)

1. Hasbani MJ, Sansing LH, Perrone J, Asbury AK, Bird SJ. Encephalopathy and peripheral neuropathy following diethylene glycol ingestion. Neurology. 2005;64(7):1273-1275.
2. Scalzo AJ. Diethylene glycol toxicity revisited. The 1996 Haitian epidemic. J Toxicol Clin Toxicol. 1996;34(5):513-516. (Pubitemid 26338655)
3. Schep LJ, Slaughter RJ, TempleWA, Beasley DM. Diethylene glycol poisoning. Clin Toxicol (Phila). 2009;47(6):525-535.
4. Ferrari LA, Giannuzzi L. Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol. Forensic Sci Int. 2005;153(1):45-51. (Pubitemid 41008651)
5. Alfred S, Coleman P, Harris D, Wigmore T, Stachowski E, Graudins A. Delayed neurologic sequelae resulting from epidemic diethylene glycol poisoning. Clin Toxicol (Phila). 2005;43(3):155-159.
6. Rollins YD, Filley CM, McNutt JT, Chahal S, Kleinschmidt-DeMasters BK. Fulminant ascending paralysis as a delayed sequela of diethylene glycol (Sterno) ingestion. Neurology. 2002;59(9):1460-1463. (Pubitemid 35286011)
7. Landry GM, Martin S, McMartin KE. Diglycolic acid in The nephrotoxic metabolite in diethylene glycol poisoning inducing necrosis in human proximal tubule cells in vitro. Toxicol Sci. 2011;124(1):35-44.
8. Besenhofer LM, McLaren MC, Latimer B, et al. Role of tissue metabolite accumulation in The renal toxicity of diethylene glycol. Toxicol Sci. 2011;123(2):374-383.
9. Schier J, Hunt DR, Perala A, et al. Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples fro. The Panama DEG mass poisoning. Clin Toxicol. 2013;51(10):923-929.
10. Schier JG, Rubin CS, Miller D, Barr D,McGeehin MA. Medication-associated diethylene glycol mass poisoning: a review and discussion of The origin of contamination. J Public Health Policy. 2009;30(2):127-143.
11. Rentz ED, Lewis L, Mujica OJ, et al. Outbreak of acute renal failure in Panama in 2006: a case-control study. BullWorld Health Organ. 2008;86(10):749-756.
12. International Society of Nephrology. KDIGO 2012 clinical practice guideline fo. The evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1-136.
13. Geiling E, Cannon P. Pathologic effects of elixir of sulfanilamide (diethylene glycol) poisoning. JAMA. 1938;111(10):919-926.