Diagnostic value of serum HE4 in endometrial cancer: A meta-analysis

World Journal of Surgical Oncology

Volumn 12, Issue 1, 2014, Pages

  Bie, Yachun ^a   Zhang, Zhenyu ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Diagnoses; Endometrial cancer (EC); HE4; Meta analysis; Serum

Indexed keywords

HUMAN EPIDIDYMIS PROTEIN 4; PROTEIN; TUMOR MARKER; WFDC2 PROTEIN, HUMAN;

ARTICLE; CLINICAL PRACTICE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ENDOMETRIUM CANCER; HUMAN; META ANALYSIS; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; BLOOD; ENDOMETRIAL NEOPLASMS; FEMALE; METABOLISM; PROGNOSIS;

ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; PROGNOSIS; PROTEINS; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84902116101     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-12-169     Document Type: Article

References (16)

1. Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffiths CT, Parker L, Zurawski VR, Knapp RC. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983, 309:883-887. 10.1056/NEJM198310133091503, 6310399.
2. Aggarwal P, Kehoe S. Serum tumour markers in gynaecological cancers. Maturitas 2010, 67:46-53. 10.1016/j.maturitas.2010.04.017, 20510555.
3. Kirchhoff C. Molecular characterization of epididymal proteins. Rev Reprod 1998, 3:86-95. 10.1530/ror.0.0030086, 9685187.
4. Abdel-Azeez HA, Labib HA, Sharaf SM, Refai AN. HE4 and mesothelin: novel biomarkers of ovarian carcinoma in patients with pelvic masses. Asian Pac J Cancer Prev 2010, 11:111-116.
5. Moore RG, Brown AK, Miller MC, Badgwell D, Lu Z, Allard WJ, Granai CO, Bast RC, Lu K. Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus. Gynecol Oncol 2008, 110:196-201. 10.1016/j.ygyno.2008.04.002, 3594093, 18495222.
6. Zanotti L, Bignotti E, Calza S, Bandiera E, Ruggeri G, Galli C, Tognon G, Ragnoli M, Romani C, Tassi RA, Caimi L, Odicino FE, Sartori E, Pecorelli S, Ravaggi A. Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome. Clin Chem Lab Med 2012, 50:2189-2198.
7. Angioli R, Plotti F, Capriglione S, Montera R, Damiani P, Ricciardi R, Aloisi A, Luvero D, Cafa EV, Dugo N, Angelucci M, Benedetti-Panici P. The role of novel biomarker HE4 in endometrial cancer: a case control prospective study. Tumour Biol 2013, 34:571-576. 10.1007/s13277-012-0583-0, 23179397.
8. Omer B, Genc S, Takmaz O, Dirican A, Kusku-Kiraz Z, Berkman S, Gurdol F. The diagnostic role of human epididymis protein 4 and serum amyloid-A in early-stage endometrial cancer patients. Tumour Biol 2013, 34:2645-2650. 10.1007/s13277-013-0814-z, 23640061.
9. Bignotti E, Ragnoli M, Zanotti L, Calza S, Falchetti M, Lonardi S, Bergamelli S, Bandiera E, Tassi RA, Romani C, Todeschini P, Odicino FE, Facchetti F, Pecorelli S, Ravaggi A. Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients. Br J Cancer 2011, 104:1418-1425. 10.1038/bjc.2011.109, 3101927, 21468050.
10. Zhang AM, Zhang P. [Clinical value of combined detection of serum human epididymal secretory protein E4 and CA(125) in the diagnosis of endometrial carcinoma]. Zhonghua Fu Chan Ke Za Zhi 2012, 47:125-128.
11. Angioli R, Miranda A, Aloisi A, Montera R, Capriglione S, De CiccoNardone C, Terranova C, Plotti F. A critical review on HE4 performance in endometrial cancer: where are we now?. Tumour Biol 2014, 35:881-887. 10.1007/s13277-013-1190-4, 24068567.
12. Plebani M, . HE4 Study Group HE4 in gynecological cancers: report of a European investigators and experts meeting. Clin Chem Lab Med 2012, 50:2127-2136. HE4 Study Group.
13. Mutz-Dehbalaie I, Egle D, Fessler S, Hubalek M, Fiegl H, Marth C, Widschwendter A. HE4 is an independent prognostic marker in endometrial cancer patients. Gynecol Oncol 2012, 126:186-191. 10.1016/j.ygyno.2012.04.022, 22525819.
14. Galgano MT, Hampton GM, Frierson HF. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol 2006, 19:847-853.
15. Jacob F, Meier M, Caduff R, Goldstein D, Pochechueva T, Hacker N, Fink D, Heinzelmann-Schwarz V. No benefit from combining HE4 and CA125 as ovarian tumor markers in a clinical setting. Gynecol Oncol 2011, 121:487-491. 10.1016/j.ygyno.2011.02.022, 21420727.
16. Bolstad N, Oijordsbakken M, Nustad K, Bjerner J. Human epididymis protein 4 reference limits and natural variation in a Nordic reference population. Tumour Biol 2012, 33:141-148. 10.1007/s13277-011-0256-4, 3235278, 22105734.