Pharmacokinetic/pharmacodynamic evaluation of sulbactam against Acinetobacter baumannii in in vitro and murine thigh and lung infection models

International Journal of Antimicrobial Agents

Volumn 43, Issue 6, 2014, Pages 547-552

  Yokoyama, Yuta ^a   Matsumoto, Kazuaki ^a   Ikawa, Kazuro ^b   Watanabe, Erika ^a   Shigemi, Akari ^a   Umezaki, Yasuhiro ^a   Nakamura, Koyo ^a   Ueno, Keiichiro ^a   Morikawa, Norifumi ^b   Takeda, Yasuo ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Acinetobacter baumannii; Infection mouse model; Pharmacokinetic pharmacodynamic; Sulbactam

Indexed keywords

SULBACTAM; ANTIINFECTIVE AGENT;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG ELIMINATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFECTION; LUNG INFECTION; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MURINE MODEL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; SINGLE DRUG DOSE; THIGH INFECTION; ABSCESS; ACINETOBACTER INFECTIONS; ANIMAL; BACTERIAL LOAD; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; LUNG; MICROBIAL SENSITIVITY TEST; MICROBIAL VIABILITY; PATHOLOGY; PLASMA; PNEUMONIA, BACTERIAL; THIGH;

ABSCESS; ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL LOAD; DISEASE MODELS, ANIMAL; FEMALE; LUNG; MICE; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; PLASMA; PNEUMONIA, BACTERIAL; SULBACTAM; THIGH;

EID: 84902113531     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2014.02.012     Document Type: Article

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