Characterization, Biomarkers, and Reversibility of a Monoclonal Antibody-induced Immune Complex Disease in Cynomolgus Monkeys (Macaca fascicularis)

Toxicologic Pathology

Volumn 42, Issue 4, 2014, Pages 765-773

  Heyen, Jonathan R ^a   Rojko, Jennifer ^b   Evans, Mark ^a   Brown, Tom P ^a   Bobrowski, Walter F ^a   Vitsky, Allison ^a   Dalton, Shana ^c   Tripathi, Niraj ^c   Bollini, Sangeetha Subbarao ^a   Johnson, Theodore ^a   Lin, John C ^a   Khan, Nasir ^a   Han, Bora ^a   Morton, Daniel ^a   Tomlinson, Lindsay ^a  

^a PFIZER INC   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

^c 206 Carnegie Center   (United States)

Author keywords

antidrug antibody; cynomolgus monkeys; glomerulonephropathy; immune complex disease; Macaca fascicularis; type III hypersensitivity; vasculopathy

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C4D; COMPLEMENT MEMBRANE ATTACK COMPLEX; DRUG ANTIBODY; IMMUNOGLOBULIN; INTERLEUKIN 6; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RN6G; UNCLASSIFIED DRUG; C REACTIVE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; SC5B-9 PROTEIN COMPLEX; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DRUG BLOOD LEVEL; ERYTHROCYTE; EUTHANASIA; FEMALE; GLOMERULUS; HISTOPATHOLOGY; IMMUNE COMPLEX DISEASE; IMMUNOHISTOCHEMISTRY; MACACA FASCICULARIS; MALE; MONOCYTOSIS; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; THROMBOCYTOPENIA; TOXICOKINETICS; TRANSMISSION ELECTRON MICROSCOPY; UREMIA; URINALYSIS; ADVERSE DRUG REACTION; ANIMAL; BLOOD; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG SCREENING; METABOLISM; PATHOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOMARKERS; C-REACTIVE PROTEIN; COMPLEMENT MEMBRANE ATTACK COMPLEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; IMMUNE COMPLEX DISEASES; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACACA FASCICULARIS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; TUMOR NECROSIS FACTOR-ALPHA; URINALYSIS;

EID: 84902112716     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623314522559     Document Type: Article

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