Small molecules and small molecule drugs in regenerative medicine

Drug Discovery Today

Volumn 19, Issue 6, 2014, Pages 801-808

  Lu, Baisong ^a   Atala, Anthony ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL MOLECULE TRANSPORT AGENT; DRUG;

ADULT STEM CELL; CELL DIFFERENTIATION; CELL INTERACTION; CELL REGENERATION; CELL THERAPY; EMBRYONIC STEM CELL; HUMAN; NONHUMAN; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REVIEW; STEM CELL; TARGET CELL; TISSUE ENGINEERING; TISSUE REGENERATION; ANIMAL; BIOLOGICAL THERAPY; PROCEDURES; STEM CELL TRANSPLANTATION;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; HUMANS; PHARMACEUTICAL PREPARATIONS; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION;

EID: 84902106977     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.11.011     Document Type: Review

References (60)

1. C. Mason, and P. Dunnill A brief definition of regenerative medicine Regen. Med. 3 2008 1 5 (Pubitemid 351541190)
2. J.A. Thomson et al. Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145 1147 (Pubitemid 28516247)
3. S.D. Schwartz et al. Embryonic stem cell trials for macular degeneration: a preliminary report Lancet 379 2012 713 720
4. K. Takahashi et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872 (Pubitemid 350138099)
5. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
6. B.Y. Hu et al. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency Proc. Natl. Acad. Sci. U. S. A. 107 2010 4335 4340
7. K. Si-Tayeb et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells Hepatology 51 2010 297 305
8. A. Raya et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells Nature 460 2009 53 59
9. K. Tateishi et al. Generation of insulin-secreting islet-like clusters from human skin fibroblasts J. Biol. Chem. 283 2008 31601 31607
10. D.E. Buchholz et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells Stem Cells 27 2009 2427 2434
11. T. Awaya et al. Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells PLoS ONE 7 2012 e51638
12. S. Karumbayaram et al. Directed differentiation of human-induced pluripotent stem cells generates active motor neurons Stem Cells 27 2009 806 811
13. L. Zwi et al. Cardiomyocyte differentiation of human induced pluripotent stem cells Circulation 120 2009 1513 1523
14. J.C. Ra et al. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans Stem Cells Dev. 20 2011 1297 1308
15. T. Wong et al. The role of fibroblasts in tissue engineering and regeneration Br. J. Dermatol. 156 2007 1149 1155 (Pubitemid 47029846)
16. R.A. Oldershaw Cell sources for the regeneration of articular cartilage: the past, the horizon and the future Int. J. Exp. Pathol. 93 2012 389 400
17. A. Atala et al. Tissue-engineered autologous bladders for patients needing cystoplasty Lancet 367 2006 1241 1246
18. H.C. Ott et al. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart Nat. Med. 14 2008 213 221 (Pubitemid 351214548)
19. B.E. Uygun et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix Nat. Med. 16 2010 814 820
20. H.C. Ott et al. Regeneration and orthotopic transplantation of a bioartificial lung Nat. Med. 16 2010 927 933
21. E.A. Ross et al. Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds J. Am. Soc. Nephrol. 20 2009 2338 2347
22. P. Macchiarini et al. First human transplantation of a bioengineered airway tissue J. Thorac. Cardiovasc. Surg. 128 2004 638 641 (Pubitemid 39278409)
23. P. Macchiarini et al. Clinical transplantation of a tissue-engineered airway Lancet 372 2008 2023 2030
24. C.A. Lyssiotis et al. Chemical control of stem cell fate and developmental potential Angew. Chem. Int. Ed. Engl. 50 2011 200 242
25. K. Watanabe et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells Nat. Biotechnol. 25 2007 681 686 (Pubitemid 46897207)
26. N. Sato et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor Nat. Med. 10 2004 55 63 (Pubitemid 38524699)
27. R. Krawetz et al. Large-scale expansion of pluripotent human embryonic stem cells in stirred-suspension bioreactors Tissue Eng. C 16 2010 573 582
28. A. Behfar et al. Stem cell differentiation requires a paracrine pathway in the heart FASEB J. 16 2002 1558 1566 (Pubitemid 35154638)
29. K.A. D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells Nat. Biotechnol. 24 2006 1392 1401 (Pubitemid 44722103)
30. X.J. Li et al. Specification of motoneurons from human embryonic stem cells Nat. Biotechnol. 23 2005 215 221
31. L. Yang et al. Human cardiovascular progenitor cells develop from a KDR1 embryonic-stem-cell-derived population Nature 453 2008 524 528 (Pubitemid 351733312)
32. A. Kirkeby et al. Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions Cell Rep. 1 2012 703 714
33. S.J. Kattman et al. Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Cell Stem Cell 8 2011 228 240
34. J. Yu et al. Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
35. Y. Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells Cell Stem Cell 2 2008 525 528 (Pubitemid 351729222)
36. Y. Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds Cell Stem Cell 3 2008 568 574
37. J.K. Ichida et al. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog Cell Stem Cell 5 2009 491 503
38. D. Huangfu et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds Nat. Biotechnol. 26 2008 795 797 (Pubitemid 351961456)
39. M.A. Esteban et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells Cell Stem Cell 6 2010 71 79
40. Z. Li, and T.M. Rana A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation Nat. Commun. 3 2012 1085
41. R. Trokovic et al. Small molecule inhibitors promote efficient generation of induced pluripotent stem cells from human skeletal myoblasts Stem Cells Dev. 22 2013 114 123
42. P. Hou et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds Science 341 2013 651 654
43. M. Kiuru et al. Genetic control of wayward pluripotent stem cells and their progeny after transplantation Cell Stem Cell 4 2009 289 300
44. Q. Zhao et al. Safeguarding pluripotent stem cells for cell therapy with a non-viral, non-integrating episomal suicide construct Biomaterials 33 2012 7261 7271
45. U. Ben-David et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen Cell Stem Cell 12 2013 167 179
46. S. Tohyama et al. Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes Cell Stem Cell 12 2013 127 137
47. S.J. Morrison, and A.C. Spradling Stem cells and niches: mechanisms that promote stem cell maintenance throughout life Cell 132 2008 598 611 (Pubitemid 351253690)
48. V. Korinek et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 Nat. Genet. 19 1998 379 383 (Pubitemid 28357912)
49. L. Soucek et al. Modelling Myc inhibition as a cancer therapy Nature 455 2008 679 683
50. T. Shingo et al. Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells J. Neurosci. 21 2001 9733 9743 (Pubitemid 34184059)
51. T.C. Luis et al. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion Cell Stem Cell 9 2011 345 356
52. R.D. Paladini et al. Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway J. Invest. Dermatol 125 2005 638 646
53. K. Sternberg et al. Implant-associated local drug delivery systems based on biodegradable polymers: customized designs for different medical applications Biomed. Tech. 58 2013 417 427
54. L.L. Lairson et al. Small molecule-based approaches to adult stem cell therapies Annu. Rev. Pharmacol. Toxicol. 53 2013 107 125
55. T. Ma et al. Progress in the reprogramming of somatic cells Circ. Res. 112 2013 562 574
56. Q. Zhou et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632
57. L. Qian et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes Nature 485 2012 593 598
58. T.E. North et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis Nature 447 2007 1007 1011 (Pubitemid 46975751)
59. A. Kuratnik, and C. Giardina Intestinal organoids as tissue surrogates for toxicological and pharmacological studies Biochem. Pharmacol. 85 2013 1721 1726
60. M. Huch et al. In vitro expansion of single Lgr51 liver stem cells induced by Wnt-driven regeneration Nature 494 2013 247 250