Treatment of refractory diabetic gastroparesis: Western medicine and traditional Chinese medicine therapies

World Journal of Gastroenterology

Volumn 20, Issue 21, 2014, Pages 6504-6514

  Pang, Bing ^a   Zhou, Qiang ^a   Li, Jun Ling ^b   Zhao, Lin Hua ^a   Tong, Xiao Lin ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Botulinum toxin; Gastric electrical stimulation; Nutrition; Refractory diabetic gastroparesis; Surgery; Traditional Chinese treatment

Indexed keywords

BETHANECHOL; BOTULINUM TOXIN; CISAPRIDE; DOMPERIDONE; ERYTHROMYCIN; METOCLOPRAMIDE; TEGASEROD;

ACUPUNCTURE; BIOMEDICINE; CHINESE MEDICINE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DISEASE ASSOCIATION; ELECTROSTIMULATION THERAPY; GASTRIC ELECTRICAL STIMULATION; HUMAN; META ANALYSIS (TOPIC); NUTRITIONAL SUPPORT; PATHOGENESIS; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REFRACTORY DIABETIC GASTROPARESIS; REVIEW; STOMACH PARESIS; SURGICAL TECHNIQUE; TRADITIONAL MEDICINE; TREATMENT OUTCOME; CHINA; CHRONIC DISEASE; DIABETES COMPLICATIONS; ENDOSCOPY; GASTROPARESIS; PATHOLOGY; PYLORUS; STOMACH; SURGERY;

BOTULINUM TOXINS; CHINA; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; DIABETES COMPLICATIONS; ELECTRIC STIMULATION THERAPY; ENDOSCOPY; GASTROPARESIS; HUMANS; MEDICINE, CHINESE TRADITIONAL; NUTRITIONAL SUPPORT; PYLORUS; STOMACH; TREATMENT OUTCOME;

EID: 84902106896     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i21.6504     Document Type: Review

References (95)

1. Parkman HP, Hasler WL, Fisher RS. American Gastroenterological Association medical position statement: diagnosis and treatment of gastroparesis. Gastroenterology 2004; 127: 1589-1591 [PMID: 15521025 DOI: 10.1053/ j.gastro.2004.09.054]
2. Abell TL, Bernstein RK, Cutts T, Farrugia G, Forster J, Hasler WL, McCallum RW, Olden KW, Parkman HP, Parrish CR, Pasricha PJ, Prather CM, Soffer EE, Twillman R, Vinik AI. Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil 2006; 18: 263-283 [PMID: 16553582 DOI: 10.1111/j.1365-2982.2006.00760.x]
3. Horowitz M, Harding PE, Maddox AF, Wishart JM, Akkermans LM, Chatterton BE, Shearman DJ. Gastric and oesophageal emptying in patients with type 2 (non-insulindependent) diabetes mellitus. Diabetologia 1989; 32: 151-159 [PMID: 2753246 DOI: 10.1111/j.1440-1746.1986.tb00104.x]
4. Camilleri M. Clinical practice. Diabetic gastroparesis. N Engl J Med 2007; 356: 820-829 [PMID: 17314341 DOI: 10.1056/ NEJMcp062614]
5. Waseem S, Moshiree B, Draganov PV. Gastroparesis: current diagnostic challenges and management considerations. World J Gastroenterol 2009; 15: 25-37 [PMID: 19115465 DOI: 10.3748/wjg.15.25]
6. Syed AA, Rattansingh A, Furtado SD. Current perspectives on the management of gastroparesis. J Postgrad Med 2005; 51: 54-60 [PMID: 15793344]
7. Abell TL, Malinowski S, Minocha A. Nutrition aspects of gastroparesis and therapies for drug-refractory patients. Nutr Clin Pract 2006; 21: 23-33 [PMID: 16439767 DOI: 10.1177 /011542650602100123]
8. Hyett B, Martinez FJ, Gill BM, Mehra S, Lembo A, Kelly CP, Leffler DA. Delayed radionucleotide gastric emptying studies predict morbidity in diabetics with symptoms of gastroparesis. Gastroenterology 2009; 137: 445-452 [PMID: 19410575 DOI: 10.1053/j.gastro.2009.04.055]
9. Reddymasu SC, Sarosiek I, McCallum RW. Severe gastroparesis: medical therapy or gastric electrical stimulation. Clin Gastroenterol Hepatol 2010; 8: 117-124 [PMID: 19765675 DOI: 10.1016/j.cgh.2009.09.010]
10. Ma J, Rayner CK, Jones KL, Horowitz M. Diabetic gastroparesis: diagnosis and management. Drugs 2009; 69: 971-986 [PMID: 19496627]
11. Vinik AI, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation 2007; 115: 387-397 [PMID: 17242296 DOI: 10.1161/CIRCULATIONAHA.106.634949]
12. Timratana P, El-Hayek K, Shimizu H, Kroh M, Chand B. Laparoscopic gastric electrical stimulation for medically refractory diabetic and idiopathic gastroparesis. J Gastrointest Surg 2013; 17: 461-470 [PMID: 23288718 DOI: 10.1007/ s11605-012-2128-7]
13. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R, Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR, Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil 2010; 22: 113-133 [PMID: 20003077 DOI: 10.1111/j.1365-2982.2009.01434.x]
14. Tougas G, Eaker EY, Abell TL, Abrahamsson H, Boivin M, Chen J, Hocking MP, Quigley EM, Koch KL, Tokayer AZ, Stanghellini V, Chen Y, Huizinga JD, Rydén J, Bourgeois I, McCallum RW. Assessment of gastric emptying using a low fat meal: establishment of international control values. Am J Gastroenterol 2000; 95: 1456-1462 [PMID: 10894578 DOI: 10.1111/j.1572-0241.2000.02076.x]
15. Lin Z, Sarosiek I, Forster J, Ross RA, Chen JD, McCallum RW. Two-channel gastric pacing in patients with diabetic gastroparesis. Neurogastroenterol Motil 2011; 23: 912-e396 [PMID: 21806741 DOI: 10.1111/j.1365-2982.2011.01754.x]
16. Abell T, McCallum R, Hocking M, Koch K, Abrahamsson H, Leblanc I, Lindberg G, Konturek J, Nowak T, Quigley EM, Tougas G, Starkebaum W. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology 2003; 125: 421-428 [PMID: 12891544 DOI: 10.1016/ S0016-5085(03)00878-3]
17. China Association of Traditional Chinese Medicine. Guideline for TCM Diabetes Prevention and Treatment. Beijing: Traditional Chinese Medicine Press of China, 2007: 39
18. Tong XL. Tang Luo, Za Bing Lun. Beijing: Science Press, 2010: 150
19. Liu WK, Dong L, Su H. Experiential examples of syndrome differentiation and treatment on diabetic gastrointestinal dysfunction by Professor Tong Xiao-Lin. Sichuan Zhongyi 2010; 28: 4-6
20. Pang B, Zhou Q, Li JL, Tong XL. Clinical Experience from Tong Xiao-Lin in treating diabetic gastroparesis. Zhonghua Zhongyiyao Zazhi 2014.In press
21. Talley NJ. Diabetic gastropathy and prokinetics. Am J Gastroenterol 2003; 98: 264-271 [PMID: 12591039 DOI: 10.1111/ j.1572-0241.2003.07268.x]
22. Jones KL, Russo A, Stevens JE, Wishart JM, Berry MK, Horowitz M. Predictors of delayed gastric emptying in diabetes. Diabetes Care 2001; 24: 1264-1269 [PMID: 11423513 DOI: 10.2337/diacare.24.7.1264]
23. Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003; 98: 783-788 [PMID: 12738456 DOI: 10.1111/ j.1572-0241.2003.07389.x]
24. Revicki DA, Rentz AM, Dubois D, Kahrilas P, Stanghellini V, Talley NJ, Tack J. Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms. Qual Life Res 2004; 13: 833-844 [PMID: 15129893 DOI: 10.1023/B: QURE.0000021689.86296.e4]
25. Revicki DA, Camilleri M, Kuo B, Norton NJ, Murray L, Palsgrove A, Parkman HP. Development and content validity of a gastroparesis cardinal symptom index daily diary. Aliment Pharmacol Ther 2009; 30: 670-680 [PMID: 19558608 DOI: 10.1111/j.1365-2036.2009.04078.x]
26. Hasler WL. Gastroparesis: symptoms, evaluation, and treatment. Gastroenterol Clin North Am 2007; 36: 619-647[PMID: 17950441 DOI: 10.1016/j.gtc.2007.07.004]
27. Abrahamsson H. Treatment options for patients with severe gastroparesis. Gut 2007; 56: 877-883 [PMID: 17519490 DOI: 10.1136/gut.2005.078121]
28. Hejazi RA, McCallum RW. Treatment of refractory gastroparesis: gastric and jejunal tubes, botox, gastric electrical stimulation, and surgery. Gastrointest Endosc Clin N Am 2009; 19: 73-82[PMID: 19232282 DOI: 10.1016/j.giec.2008.12.010]
29. Sturm A, Holtmann G, Goebell H, Gerken G. Prokinetics in patients with gastroparesis: a systematic analysis. Digestion 1999; 60: 422-427 [PMID: 10473966 DOI: 10.1159/000007687]
30. Patterson D, Abell T, Rothstein R, Koch K, Barnett J. A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. Am J Gastroenterol 1999; 94: 1230-1234 [PMID: 10235199]
31. Gentilcore D, O'Donovan D, Jones KL, Horowitz M. Nutrition therapy for diabetic gastroparesis. Curr Diab Rep 2003; 3: 418-426 [PMID: 12975033 DOI: 10.1007/s11892-003-0087-9]
32. Lehmann R, Honegger RA, Feinle C, Fried M, Spinas GA, Schwizer W. Glucose control is not improved by accelerating gastric emptying in patients with type 1 diabetes mellitus and gastroparesis. a pilot study with cisapride as a model drug. Exp Clin Endocrinol Diabetes 2003; 111: 255-261 [PMID: 12951630 DOI: 10.1055/s-2003-41283]
33. Kashyap P, Farrugia G. Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years. Gut 2010; 59: 1716-1726 [PMID: 20871131 DOI: 10.1136/gut.2009.199703]
34. Ejskjaer N, Vestergaard ET, Hellström PM, Gormsen LC, Madsbad S, Madsen JL, Jensen TA, Pezzullo JC, Christiansen JS, Shaughnessy L, Kosutic G. Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis. Aliment Pharmacol Ther 2009; 29: 1179-1187 [PMID: 19298585 DOI: 10.1111/ j.1365-2036.2009.03986.x]
35. Wo JM, Ejskjaer N, Hellström PM, Malik RA, Pezzullo JC, Shaughnessy L, Charlton P, Kosutic G, McCallum RW. Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting- -randomised clinical study subset data. Aliment Pharmacol Ther 2011; 33: 679-688 [PMID: 21214610 DOI: 10.1111/ j.1365-2036.2010.04567.x]
36. Chong K, Dhatariya K. A case of severe, refractory diabetic gastroparesis managed by prolonged use of aprepitant. Nat Rev Endocrinol 2009; 5: 285-288 [PMID: 19444262 DOI: 10.1038/nrendo.2009.50]
37. Kim SW, Shin IS, Kim JM, Kang HC, Mun JU, Yang SJ, Yoon JS. Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment. Psychosomatics 2006; 47: 440-442 [PMID: 16959934 DOI: 10.1176/appi.psy.47.5.440]
38. Farmer AD, Kadirkamanathan SS, Aziz Q. Diabetic gastroparesis: pathophysiology, evaluation and management. Br J Hosp Med (Lond) 2012; 73: 451-456 [PMID: 22875523]
39. Wu DJ, Dib C, Hoelzer B, McMahon M, Mueller P. Coeliac plexus block in the management of chronic abdominal pain due to severe diabetic gastroparesis. BMJ Case Rep 2009; 2009. [PMID: 22121392 DOI: 10.1136/bcr.06.2009.1986]
40. Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L. Clinical guideline: management of gastroparesis. Am J Gastroenterol 2013; 108: 18-37quiz 38 [PMID: 23147521 DOI: 10.1038/ajg.2012.373]
41. Cogen R, Weinryb J, Pomerantz C, Fenstemacher P. Complications of jejunostomy tube feeding in nursing facility patients. Am J Gastroenterol 1991; 86: 1610-1613 [PMID: 1951238]
42. Karamanolis G, Tack J. Nutrition and motility disorders. Best Pract Res Clin Gastroenterol 2006; 20: 485-505 [PMID: 16782525 DOI: 10.1016/j.bpg.2006.01.005]
43. Fontana RJ, Barnett JL. Jejunostomy tube placement in refractory diabetic gastroparesis: a retrospective review. Am J Gastroenterol 1996; 91: 2174-2178 [PMID: 8855743]
44. Jacober SJ, Narayan A, Strodel WE, Vinik AI. Jejunostomy feeding in the management of gastroparesis diabeticorum. Diabetes Care 1986; 9: 217-219 [PMID: 3084186]
45. Ginsberg GG, Lipman TO, Fleischer DE. Endoscopic clipassisted placement of enteral feeding tubes. Gastrointest Endosc 1994; 40: 220-222 [PMID: 8013825 DOI: 10.1016/ S0016-5107(94)70170-9]
46. Revicki DA, Rentz AM, Dubois D, Kahrilas P, Stanghellini V, Talley NJ, Tack J. Development and validation of a patient-assessed gastroparesis symptom severity measure: the Gastroparesis Cardinal Symptom Index. Aliment Pharmacol Ther 2003; 18: 141-150 [PMID: 12848636 DOI: 10.1046/ j.0269-2813.2003.01612.x]
47. Kim CH, Nelson DK. Venting percutaneous gastrostomy in the treatment of refractory idiopathic gastroparesis. Gastrointest Endosc 1998; 47: 67-70 [PMID: 9468426 DOI: 10.1016/ S0016-5107(98)70301-3]
48. Guerci B, Bourgeois C, Bresler L, Scherrer ML, Böhme P. Gastric electrical stimulation for the treatment of diabetic gastroparesis. Diabetes Metab 2012; 38: 393-402 [PMID: 22742875 DOI: 10.1016/j.diabet.2012.05.001]
49. McKenna D, Beverstein G, Reichelderfer M, Gaumnitz E, Gould J. Gastric electrical stimulation is an effective and safe treatment for medically refractory gastroparesis. Surgery 2008; 144: 566-572discussion 572-574 [PMID: 18847640 DOI: 10.1016/j.surg.2008.06.024]
50. US Food and Drug Administration. H990014-Enterra Therapy System (formerly named Gastric Electrical Stimulation (GES) system). Cited 22 Sep 2010. Available from: URL: http://www.fda.gov/cdrh/ode/H990014sum.html
51. Maranki JL, Lytes V, Meilahn JE, Harbison S, Friedenberg FK, Fisher RS, Parkman HP. Predictive factors for clinical improvement with Enterra gastric electric stimulation treatment for refractory gastroparesis. Dig Dis Sci 2008; 53: 2072-2078 [PMID: 18080765 DOI: 10.1007/s10620-007-0124-7]
52. Lin Z, Hou Q, Sarosiek I, Forster J, McCallum RW. Association between changes in symptoms and gastric emptying in gastroparetic patients treated with gastric electrical stimulation. Neurogastroenterol Motil 2008; 20: 464-470 [PMID: 18086205 DOI: 10.1111/j.1365-2982.2007.01054.x]
53. McCallum RW, Dusing R, McMillin C. Fluoro-deoxyglucose (FDG) positron emission tomography (PET) in gastroparetic patients before and during gastric electrical stimulation (GES). Gastroenterol 2005; 128: A622 abstract
54. McCallum RW, Lin Z, Forster J, Roeser K, Hou Q, Sarosiek I. Gastric electrical stimulation improves outcomes of patients with gastroparesis for up to 10 years. Clin Gastroenterol Hepatol 2011; 9: 314-319.e1 [PMID: 21185396 DOI: 10.1016/ j.cgh.2010.12.013]
55. McCallum RW, Dusing RW, Sarosiek I, Cocjin J, Forster J, Lin Z. Mechanisms of symptomatic improvement after gastric electrical stimulation in gastroparetic patients. Neurogastroenterol Motil 2010; 22: 161-167. e50-51 [PMID: 19719511 DOI: 10.1111/j.1365-2982.2009.01389.x]
56. Zhang J, Chen JD. Systematic review: applications and future of gastric electrical stimulation. Aliment Pharmacol Ther 2006; 24: 991-1002 [PMID: 16984493 DOI: 10.1111/ j.1365-2036.2006.03087.x]
57. Lin Z, McElhinney C, Sarosiek I, Forster J, McCallum R. Chronic gastric electrical stimulation for gastroparesis reduces the use of prokinetic and/or antiemetic medications and the need for hospitalizations. Dig Dis Sci 2005; 50: 1328-1334 [PMID: 16047482 DOI: 10.1007/s10620-005-2782-7]
58. Kastenmeier AS, Makris KI, Dunst CM, Swanstrom LL. Gastric Electrical Stimulation: Surgical Complications and Impact on Supplemental Nutrition (Poster). Chicago, IL: DDW Annual Meeting, 2011
59. Musunuru S, Beverstein G, Gould J. Preoperative predictors of significant symptomatic response after 1 year of gastric electrical stimulation for gastroparesis. World J Surg 2010; 34: 1853-1858 [PMID: 20411386 DOI: 10.1007/s00268-010-0586-1]
60. Abrahamsson H. Severe gastroparesis: new treatment alternatives. Best Pract Res Clin Gastroenterol 2007; 21: 645-655 [PMID: 17643906]
61. Lacy BE, Zayat EN, Crowell MD, Schuster MM. Botulinum toxin for the treatment of gastroparesis: a preliminary report. Am J Gastroenterol 2002; 97: 1548-1552 [PMID: 12094882 DOI: 10.1111/j.1572-0241.2002.05741.x]
62. Lacy BE, Schettler-Duncan VA, Crowell MD. The treatment of diabetic gastroparesis with botulinum toxin. Am J Gastroenterol 2000; 95: 2455-2456[DOI: 10.1111/ j.1572-0241.2000.02514.x]
63. Bromer MQ, Friedenberg F, Miller LS, Fisher RS, Swartz K, Parkman HP. Endoscopic pyloric injection of botulinum toxin A for the treatment of refractory gastroparesis. Gastrointest Endosc 2005; 61: 833-839 [PMID: 15933684 DOI: 10.1016/ S0016-5107(05)00328-7]
64. Arts J, van Gool S, Caenepeel P, Verbeke K, Janssens J, Tack J. Influence of intrapyloric botulinum toxin injection on gastric emptying and meal-related symptoms in gastroparesis patients. Aliment Pharmacol Ther 2006; 24: 661-667 [PMID: 16907899 DOI: 10.1111/j.1365-2036.2006.03019.x]
65. Coleski R, Anderson MA, Hasler WL. Factors associated with symptom response to pyloric injection of botulinum toxin in a large series of gastroparesis patients. Dig Dis Sci 2009; 54: 2634-2642 [PMID: 19184429 DOI: 10.1007/ s10620-008-0660-9]
66. Coleski R, Hasler W. Clinical and gastric functional predictors of symptom response to pyloric injection of botulinum toxin in patients with gastroparesis. Neurogastroenterol Motil 2005; 17: 628A
67. Arts J, Holvoet L, Caenepeel P, Bisschops R, Sifrim D, Verbeke K, Janssens J, Tack J. Clinical trial: a randomizedcontrolled crossover study of intrapyloric injection of botulinum toxin in gastroparesis. Aliment Pharmacol Ther 2007; 26: 1251-1258 [PMID: 17944739]
68. Friedenberg FK, Palit A, Parkman HP, Hanlon A, Nelson DB. Botulinum toxin A for the treatment of delayed gastric emptying. Am J Gastroenterol 2008; 103: 416-423 [PMID: 18070232 DOI: 10.1111/j.1572-0241.2007.01676.x]
69. Saridena PR, Saridena RA, Sarosiek I. Is total gastrectomy a good option for refractory gastroparesis? One site experience. Am J Gastroenterol 2008; 103: A147
70. Forstner-Barthell AW, Murr MM, Nitecki S, Camilleri M, Prather CM, Kelly KA, Sarr MG. Near-total completion gastrectomy for severe postvagotomy gastric stasis: analysis of early and long-term results in 62 patients. J Gastrointest Surg 1999; 3: 15-21discussion 21-23 [PMID: 10457319 DOI: 10.1016/S1091-255X(99)80003-1]
71. Jones MP, Maganti K. A systematic review of surgical therapy for gastroparesis. Am J Gastroenterol 2003; 98: 2122-2129 [PMID: 14572555 DOI: 10.1111/j.1572-0241.2003.07721.x]
72. Watkins PJ, Buxton-Thomas MS, Howard ER. Long-term outcome after gastrectomy for intractable diabetic gastroparesis. Diabet Med 2003; 20: 58-63 [PMID: 12519321]
73. Sodhi SS, Guo JP, Maurer AH, O'Brien G, Srinivasan R, Parkman HP. Gastroparesis after combined heart and lung transplantation. J Clin Gastroenterol 2002; 34: 34-39 [PMID: 11743243 DOI: 10.1097/00004836-200201000-00007]
74. Nguyen LB, Parker S, Snape WJ. Is pyloroplasty a surgical option in the treatment of refractory gastroparesis? Gastroenterology 2007; 132: M1151.4Abstract
75. Hibbard ML, Dunst CM, Swanström LL. Laparoscopic and endoscopic pyloroplasty for gastroparesis results in sustained symptom improvement. J Gastrointest Surg 2011; 15: 1513-1519 [PMID: 21720926 DOI: 10.1007/s11605-011-1607-6]
76. Sarosiek I, Forster J, Lin Z, Cherry S, Sarosiek J, McCallum R. The addition of pyloroplasty as a new surgical approach to enhance effectiveness of gastric electrical stimulation therapy in patients with gastroparesis. Neurogastroenterol Motil 2013; 25: 134-e80 [PMID: 23113904 DOI: 10.1111/nmo.12032]
77. Li JL, Li M, Pang B, Zhou Q, Zhao XY, Liu HX, Tian JX, Tong XL. "Combination of symptoms, syndrome and disease": Treatment of refractory diabetic gastroparesis. World J Gastroenterol In press
78. Qian Q, Chen W, Yue W, Yang Z, Liu Z, Qian W. Antiemetic effect of Xiao-Ban-Xia-Tang, a Chinese medicinal herb recipe, on cisplatin-induced acute and delayed emesis in minks. J Ethnopharmacol 2010; 128: 590-593 [PMID: 20097280 DOI: 10.1016/j.jep.2010.01.027]
79. Xu XY, Lian JW. The impact of Xiao-Banxia-Tang on motilin in mice. Guoyi Luntan 2002; 17: 45-46
80. Nie K, Ma SQ. The therapeutic effect of Xiao-Banxia-Tang on chemotherapy allotriophagia in mice. Zhongyao Yaoli Yu Linchuang 2007; 23: 32-33
81. Gupta YK, Sharma M. Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale). Methods Find Exp Clin Pharmacol 2001; 23: 501-503 [PMID: 11876024 DOI: 10.1358/mf.2001.23.9.662137]
82. Gonlachanvit S, Chen YH, Hasler WL, Sun WM, Owyang C. Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins. J Pharmacol Exp Ther 2003; 307: 1098-1103 [PMID: 14534370 DOI: 10.1124/jpet.103.053421]
83. Yuan MZ. Clinical Experience from Tong Xiao-Lin in treating diabetic vomiting with Pinellia. Shandong Zhongyi Zazhi 2012; 31: 762-763
84. Li JL, Zhou Q, Pang B, Li M, Tian JX, Tong XL. The experience of treatment on diabetes combined with vomiting by Professor Tong Xiao-Lin. Liaoning Zhongyi Zazhi 2013; 40: 1-3
85. Li H. 34 cases of syndrome differentiation and treatment variation on intractable hyperemesis gravidarum. Shaanxi Zhongyi 2011; 32: 1454-1455
86. Zhang JF. Su Ye Huang Lian Tang treated on severe gastrointestinal side effects caused by interferon. Shaanxi Zhongyi Xueyuan Xuebao 2007; 30: 33
87. Deng WJ. Modified Su Ye Huang Lian Tang in treating 15 patients with chronic renal failure. MudanjiangYixueyuan Xuebao 1998; 19: 84-85
88. Liu GF, Zhao JB, Zhen Z, Sha H, Chen PM, Li M, Zhang JC, Yuan MZ, Gao W, Gregersen H, Tong XL. Effect of tangweian jianji on upper gastrointestinal remodeling in streptozotocin- induced diabetic rats. World J Gastroenterol 2012; 18: 4875-4884 [PMID: 23002359 DOI: 10.3748/wjg.v18.i35.4875]
89. Zhou LB, Li BZ, Zhang JQ, Tong XL. Case examples of treatment with Fuzi Lizhong Decoction applied by Professor Tong Xiao-Lin. Collection of papers in the 12th National Diabetic Conference on TCM: 311-314
90. Ezzo J, Streitberger K, Schneider A. Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting. J Altern Complement Med 2006; 12: 489-495 [PMID: 16813514 DOI: 10.1089/acm.2006.12.489]
91. Ouyang H, Yin J, Wang Z, Pasricha PJ, Chen JD. Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J Physiol Gastrointest Liver Physiol 2002; 282: G390-G396 [PMID: 11804862 DOI: 10.1152/ ajpgi.00272.2001]
92. Wang CP, Kao CH, Chen WK, Lo WY, Hsieh CL. A singleblinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis. J Altern Complement Med 2008; 14: 833-839 [PMID: 18721079 DOI: 10.1089/acm.2008.0107]
93. Kim KH, Kim TH, Choi JY, Kim JI, Lee MS, Choi SM. Acupuncture for symptomatic relief of gastroparesis in a diabetic haemodialysis patient. Acupunct Med 2010; 28: 101-103 [PMID: 20466737 DOI: 10.1136/aim.2009.002204]
94. Yu Y, Yang Y. One case: combination of traditional Chinese and Western medicine in treatment of severe diabetic gastroparesis. Zhongguo Zhongyiyao Xiandai Yuancheng Jiaoyu 2011; 9: 84
95. Ma YJ. Clinical observation on severe diabetic gastroparesis. Zhongguo Shiyong Yiyao 2011; 6: 114-115