Synthesis of enantiopure 10-nornaltrexones in the search for toll-like receptor 4 antagonists and opioid ligands

Journal of Organic Chemistry

Volumn 79, Issue 11, 2014, Pages 5007-5018

  Selfridge, Brandon R ^a   Deschamps, Jeffrey R ^b   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOMERS; SYNTHESIS (CHEMICAL);

EFFICIENT SYNTHESIS; ENAMINES; ENANTIOPURE; ISOQUINOLINONES; OPTICAL RESOLUTION; OPTIMIZED SYNTHESIS; TOLL-LIKE RECEPTOR 4;

LIGANDS;

10 NORNALTREXONE DERIVATIVE; 3 (CYCLOPROPYLMETHYL) 4A,9 DIHYDROXY 2,3,4,4A,5,6 HEXAHYDRO 1H BENZOFURO[3,2 E]ISOQUNOLIN 7(7AH) ONE; 4 AH, 9 O TRANS 9 METHOXY 3 METHYL 2,3,4,4A,5,6 HEXAHYDRO 1H BENZOFURO [3,2 E]ISOQUINOLIN 7(7AH) ONE; NALTREXONE DERIVATIVE; PYRIDINE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VANILLIN; (12BR)-7,9-DIMETHOXY-3-METHYL-1,2,3,7-TETRAHYDRO-7,12B-METHANOBENZO(2,3)OXOCINO(5,4-C)PYRIDINE; (3-(CYCLOPROPYLMETHYL)-4A,9-DIHYDROXY-2,3,4,4A,5,6-HEXAHYDRO-1H-BENZOFURO(3,2-E)ISOQUINOLIN-7(7AH)-ONE; BENZOFURAN DERIVATIVE; ISOQUINOLINE DERIVATIVE; NALTREXONE; NARCOTIC ANALGESIC AGENT; OXOCIN DERIVATIVE; PYRIDINE DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ELIMINATION REACTION; ENANTIOMER; OPTICAL RESOLUTION; X RAY ANALYSIS; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANALGESICS, OPIOID; BENZOFURANS; ISOQUINOLINES; MOLECULAR STRUCTURE; NALTREXONE; OXOCINS; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4;

EID: 84902097181     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo500568s     Document Type: Article

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