Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (platelet inhibition and patient outcomes) trial

Journal of the American College of Cardiology

Volumn 63, Issue 15, 2014, Pages 1493-1499

  Mahaffey, Kenneth W ^a,b   Held, Claes ^c   Wojdyla, Daniel M ^a   James, Stefan K ^c   Katus, Hugo A ^d   Husted, Steen ^e   Steg, Philippe Gabriel ^f,g,h   Cannon, Christopher P ⁱ   Becker, Richard C ^a   Storey, Robert F ^j   Khurmi, Nardev S ^k   Nicolau, José C ^l   Yu, Cheuk Man ^m   Ardissino, Diego ⁿ   Budaj, Andrzej ^o   Morais, Joao ^p   Montgomery, Debra ^a   Himmelmann, Anders ^q   Harrington, Robert A ^b   Wallentin, Lars ^c  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UPPSALA CLINICAL RESEARCH CENTER   (Sweden)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e REGIONAL HOSPITAL WEST JUTLAND   (Denmark)

^f INSERM   (France)

^g BICHAT HOSPITAL   (France)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

^j UNIVERSITY OF SHEFFIELD   (United Kingdom)

^k ASTRAZENECA   (United Kingdom)

^l UNIVERSITY OF SÃO PAULO   (Brazil)

^m CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

ⁿ UNIVERSITY HOSPITAL OF PARMA   (Italy)

^o GROCHOWSKI HOSPITAL   (Poland)

^p Santo Andrés Hospital ^*  (Portugal)

^q ASTRAZENECA R AND D   (Sweden)

more..

Author keywords

acute coronary syndrome(s); adjudication; clinical events committee; clopidogrel; myocardial infarction; outcomes; ticagrelor

Indexed keywords

CLOPIDOGREL; TICAGRELOR; ACETYLSALICYLIC ACID;

ACUTE CORONARY SYNDROME; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART DEATH; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; STENT THROMBOSIS; UNSTABLE ANGINA PECTORIS; CONFIDENCE INTERVAL; CORONARY ARTERY BYPASS SURGERY; DATA ANALYSIS; HAZARD RATIO; KAPLAN MEIER METHOD; LOADING DRUG DOSE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; THROMBOCYTE AGGREGATION INHIBITION; TREATMENT OUTCOME;

ACUTE CORONARY SYNDROME(S); ADJUDICATION; CLINICAL EVENTS COMMITTEE; CLOPIDOGREL; MYOCARDIAL INFARCTION; OUTCOMES; TICAGRELOR;

ACUTE CORONARY SYNDROME; ADENOSINE; AGED; BLOOD PLATELETS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROSPECTIVE STUDIES; PURINERGIC P2Y RECEPTOR ANTAGONISTS; SURVIVAL RATE; TREATMENT OUTCOME; WORLD HEALTH;

EID: 84902095840     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2014.01.038     Document Type: Article

References (14)

1. L. Wallentin, R.C. Becker, and A. Budaj et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes N Engl J Med 361 2009 1045 1057
2. R.C. Becker, J.P. Bassand, and A. Budaj et al. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial Eur Heart J 32 2011 2933 2944
3. S. James, A. Åkerblom, and C.P. Cannon et al. Comparison of ticagrelor, the first reversible P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: rationale, design and baseline characteristics of the PLATelet inhibition and Outcomes (PLATO) trial Am Heart J 157 2009 599 605
4. F. Van de Werf, J. Bax, and A. Betriu et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology Eur Heart J 29 2008 2909 2945
5. J.L. Anderson, C.D. Adams, and E.M. Antman et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) J Am Coll Cardiol 50 2007 e1 e157
6. S. Leonardi, A.A.M. Truffa, and M.L. Neely et al. A novel approach to systematically implement the universal definition of myocardial infarction: insights from the CHAMPION PLATFORM trial Heart 99 2013 1282 1287
7. K. Thygesen, J.S. Alpert, H.D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction Universal definition of myocardial infarction Circulation 116 2007 2634 2653
8. K. Thygesen, J.S. Alpert, and A.S. Jaffe et al. Third universal definition of myocardial infarction Eur Heart J 33 2012 2551 2567
9. K.W. Mahaffey, R.A. Harrington, and M. Akkerhuis et al. Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study Curr Control Trials Cardiovasc Med 2 2001 187 194
10. K.W. Mahaffey, M.T. Roe, and C.K. Dyke et al. Misreporting of myocardial infarction end points: results of adjudication by a central clinical events committee in the PARAGON-B trial Am Heart J 143 2002 242 248
11. C.B. Granger, V. Vogel, and S.R. Cummings et al. Do we need to adjudicate major clinical events? Clin Trials 5 2008 56 60
12. V.L. Serebruany, and D. Atar Viewpoint: central adjudication of myocardial infarction in outcome-driven clinical trials-common patterns in TRITON, RECORD, and PLATO? Thromb Haemost 108 2012 412 414
13. L. Wallentin, R.C. Becker, and S.K. James et al. The PLATO trial reveals further opportunities to improve outcomes in patients with acute coronary syndrome Thromb Haemost 105 2011 760 762
14. C.P. Cannon, R.G. Brindis, and B.R. Chaitman et al. 2013 ACCF/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes and coronary artery disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Acute Coronary Syndromes and Coronary Artery Disease Clinical Data Standards) J Am Coll Cardiol 61 2013 992 1025