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•• Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, the Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. J Obstet Gynaecol Can 2014;36(5):416-438.
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the Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group This pair of papers provides the most up-to-date guidance to direct clincial care. The redefinition of what constitutes 'severe' pre-eclampsia to include only clinical variables that mandate delivery will provide greater clinical clarity than previous documents
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•• Magee LA, Pels A, Helewa M, Rey E, von Dadelszen P, the Canadian Hypertensive Disorders of Pregnancy (HDP) Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy. Pregnancy Hypertens 2014;4(2):105-45. This pair of papers provides the most up-to-date guidance to direct clincial care. The redefinition of what constitutes 'severe' pre-eclampsia to include only clinical variables that mandate delivery will provide greater clinical clarity than previous documents.
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Pregnancy Hypertens
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A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: The miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) multi-country prospective cohort study
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The demographics-, symptom- and sign-based miniPIERS model will direct community-level diagnosis and triage of women with pre-eclampsia in all settings
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• Payne BA, Hutcheon JA, Ansermino JM, Hall DR, Bhutta ZA, Bhutta SZ, et al. A risk prediction model for the assessment and triage of women with hypertensive disorders of pregnancy in low-resourced settings: the miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) multi-country prospective cohort study. PLoS Med. 2014;11(1), e1001589. The demographics-, symptom- and sign-based miniPIERS model will direct community-level diagnosis and triage of women with pre-eclampsia in all settings.
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Payne, B.A.1
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Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: A prospective multicenter study
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This paper provides a breakthrough in our ability to integrate a translational biomarker into clinical care. Placental growth factors not only assist in the diagnosis of pre-eclampsia, it identifies women at incremental risk of imminent delivery
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•• Chappell LC, Duckworth S, Seed PT, Griffin M, Myers J, Mackillop L, et al. Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation. 2013;128(19):2121-31. This paper provides a breakthrough in our ability to integrate a translational biomarker into clinical care. Placental growth factors not only assist in the diagnosis of pre-eclampsia, it identifies women at incremental risk of imminent delivery.
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Redefining preeclampsia using placenta-derived biomarkers
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The paper looks to redefining subtypes of pre-eclampsia on the basis of placental biomarkers, particularly angiongenic imbalance. Through better understanding of the pathogenesis of pre-clampsia we will be able to design effective prediction, prevention and treatment straetgies
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• Staff AC, Benton SJ, von Dadelszen P, Roberts JM, Taylor RN, Powers RW, et al. Redefining preeclampsia using placenta-derived biomarkers. Hypertension. 2013;61(5):932-42. The paper looks to redefining subtypes of pre-eclampsia on the basis of placental biomarkers, particularly angiongenic imbalance. Through better understanding of the pathogenesis of pre-clampsia we will be able to design effective prediction, prevention and treatment straetgies.
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Hypertension
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Staff, A.C.1
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Benton SJ, Hu Y, Xie F, Kupfer K, Lee SW, Magee LA, et al. Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays. Am J Obstet Gynecol. 2011;205(5):469.e1-8.
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• Benton SJ, Hu Y, Xie F, Kupfer K, Lee SW, Magee LA, et al. Can placental growth factor in maternal circulation identify fetuses with placental intrauterine growth restriction? Am J Obstet Gynecol. 2012;206(2):163-7. Angiogenic imbalance is not specific to pre-eclampsia.
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Myatt L, Clifton RG, Roberts JM, Spong CY, Hauth JC, Varner MW, et al. First-trimester prediction of preeclampsia in nulliparous women at low risk. Obstet Gynecol. 2012;119(6):1234-42.
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Kenny LC, Broadhurst DI, Dunn W, Brown M, North RA, McCowan L, et al. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension. 2010;56(4):741-9.
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This study begins to integrate placental growth factor into clinical outcome prediction modeling to identify women at increased risk for pre-eclampsia later in their pregnancy. Such women would be priorities for current prevention strategies and comprise an enriched cohort for future attempts at disease prevention related to a specific pathway to disease
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•• Myers JE, Kenny LC, McCowan LM, Chan EH, Dekker GA, Poston L, et al. Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study. BJOG. 2013;120(10):1215-23. This study begins to integrate placental growth factor into clinical outcome prediction modeling to identify women at increased risk for pre-eclampsia later in their pregnancy. Such women would be priorities for current prevention strategies and comprise an enriched cohort for future attempts at disease prevention related to a specific pathway to disease.
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