Hyperactivity, concentration difficulties and impulsiveness improve during seven weeks' treatment with valerian root and lemon balm extracts in primary school children

Phytomedicine

Volumn 21, Issue 8-9, 2014, Pages 1098-1103

  Gromball, Jürgen ^a   Beschorner, Frank ^b   Wantzen, Christian ^b   Paulsen, Ute ^c   Burkart, Martin ^c  

^a Dr Willmar Schwabe GmbH and Co KG ^*  (Germany)

^b NONE   (Germany)

^c DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

Concentration deficit; Hyperactivity; Melissa; Primary school children; Valerian lemon balm extract; Valeriana

Indexed keywords

LEMON BALM EXTRACT; NEUROLEPTIC AGENT; PLANT EXTRACT; SANDRIN; UNCLASSIFIED DRUG; VALERIAN; WS; HYPNOTIC SEDATIVE AGENT;

ANAMNESIS; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CHILD; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERACTIVITY; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; OCCUPATIONAL THERAPY; PATIENT SATISFACTION; PRIMARY SCHOOL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECOMMENDED DRUG DOSE; SOCIAL BEHAVIOR; TREATMENT OUTCOME; CHEMISTRY; CLINICAL TRIAL; GENERAL PRACTITIONER; ISOLATION AND PURIFICATION; MELISSA OFFICINALIS; PARENT; PHYTOTHERAPY; PLANT ROOT; PSYCHOMOTOR AGITATION; QUESTIONNAIRE; SLEEP INITIATION AND MAINTENANCE DISORDERS;

CITRUS LIMON; MELISSA; VALERIANA;

CHILD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MELISSA; PARENTS; PHYSICIANS, PRIMARY CARE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROSPECTIVE STUDIES; PSYCHOMOTOR AGITATION; QUESTIONNAIRES; SLEEP INITIATION AND MAINTENANCE DISORDERS; TREATMENT OUTCOME; VALERIAN;

EID: 84901978408     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.04.004     Document Type: Article

References (32)

1. A. Cerny, and K. Schmid Tolerability and efficacy of valerian/lemon balm in healthy volunteers (a double blind, placebo-controlled, multicentre study) Fitoterapia 70 1999 221 228 (Pubitemid 29377035)
2. W. Chaiyana, and S. Okonogi Inhibition of cholinesterase by essential oil from food plant Phytomedicine 19 2012 836 839
3. C. Circosta, R. De Pasquale, S. Samperi, A. Pino, and F. Occhiuto Biological and analytical characterization of two extracts from Valeriana officinalis J. Ethnopharmacol. 112 2007 361 367 (Pubitemid 46756080)
4. K. Dastmalchi, V. Ollilainen, P. Lackman, G. Boije af Gennäs, H.J. Dorman, P.P. Järvinen, J. Yli-Kauhaluoma, and R. Hiltunen Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorg. Med. Chem. 17 2009 867 871
5. A. Diaper, and I. Hindmarch A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults Phytother. Res. 18 2004 831 836 (Pubitemid 39577247)
6. B.M. Dietz, G.B. Mahady, G.F. Pauli, and N.R. Farnsworth Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro Brain Res. Mol. Brain Res. 138 2005 191 197 (Pubitemid 41138038)
7. F. Donath, S. Quispe, K. Diefenbach, A. Maurer, I. Fietze, and I. Roots Critical evaluation of the effect of valerian extract on sleep structure and sleep quality Pharmacopsychiatry 33 2000 47 53 (Pubitemid 30161106)
8. J.L. Donovan, C.L. DeVane, K.D. Chavin, J.S. Wang, B.B. Gibson, H.A. Gefroh, and J.S. Markowitz Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers Drug Metab. Dispos. 32 2004 1333 1336 (Pubitemid 39564550)
9. H. Dreßing, S. Köhler, and W.E. Müller Improvement of sleep quality with a highly dosed valerian/balm preparation: a placebo-controlled double-blind study Psychopharmakotherapie 3 1996 123 130 (Pubitemid 26278240)
10. M.I. Fernández-San-Martín, R. Masa-Font, L. Palacios-Soler, P. Sancho-Gómez, C. Calbó-Caldentey, and G. Flores-Mateo Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials Sleep Med. 11 2010 505 511
11. A.J. Francis, and R.J. Dempster Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial Phytomedicine 9 2002 273 279 (Pubitemid 34712497)
12. B. Gebhardt, E. Finne, O. von Rahden, P. Kolip, G. Glaeske, and E. Würdemann ADHS bei Kindern und Jugendlichen. Befragungsergebnisse und Auswertungen von Daten der Gmünder ErsatzKasse GEK. Bremen/Schwäbisch Gmünd 2008 http://www.bptk.de/uploads/media/20081015-adhs-bei-kindern-und- jugendlichen-gek-report.pdf
13. J.R. Glass, B.A. Sproule, N. Herrmann, D. Streiner, and U.E. Busto Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects J. Clin. Psychopharmacol. 23 2003 260 268 (Pubitemid 36807793)
14. K.T. Hallam, J.S. Olver, C. McGrath, and T.R. Norman Comparative cognitive and psychomotor effects of single doses of Valeriana officinalis and triazolam in healthy volunteers Hum. Psychopharmacol. 18 2003 619 625 (Pubitemid 38028788)
15. HMPC, European Commission Herbal Products Committee, 2007. Assessment report on Valeriana officinalis L., Radix., Doc Ref. EMEA/HMPC/167391/2006.
16. A.V. Kamm-Kohl, W. Jansen, and P. Brockmann Moderne Baldriantherapie gegen nervöse Störungen im Senium Med. Welt. 35 1984 1450 1454 (Pubitemid 14019935)
17. D.O. Kennedy, A.B. Scholey, N.T. Tildesley, E.K. Perry, and K.A. Wesnes Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm) Pharmacol. Biochem. Behav. 72 2002 953 964 (Pubitemid 34621322)
18. D.O. Kennedy, G. Wake, S. Savelev, N.T. Tildesley, E.K. Perry, K.A. Wesnes, and A.B. Scholey Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties Neuropsychopharmacology 28 2003 1871 1881 (Pubitemid 41070853)
19. D.O. Kennedy, W. Little, and A.B. Scholey Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm) Psychosom. Med. 66 2004 607 613 (Pubitemid 38971258)
20. S. Khom, I. Baburin, E. Timin, A. Hohaus, G. Trauner, B. Kopp, and S. Hering Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity Neuropharmacology 53 2007 178 187 (Pubitemid 47125958)
21. K. Kraft Phytopharmaka bei Kindern - Indikationen, Möglichkeiten, Grenzen Kinderärztliche Praxis 79 2008 282 289
22. M.M. Larzelere, J.S. Campbell, and M. Robertson Complementary and alternative medicine usage for behavioral health indications Prim. Care 37 2010 213 236
23. C.M. Morin, U. Koetter, C. Bastien, J.C. Ware, and V. Wooten Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial Sleep 28 2005 1465 1471 (Pubitemid 41573696)
24. S.F. Müller, and S. Klement A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children Phytomedicine 13 2006 383 387 (Pubitemid 43744416)
25. Pharmacopoea Europaea, Ph. Eur. 7.1/1898 Valerianae extractum hydroalcoholicum siccum Pharmacopoea Europaea, Ph. Eur 7.0/2524 Melissae folii extractum siccum.
26. H. Saß, H.U. Wittchen, M. Zaudig, and I. Houben Diagnostisches und Statistisches Manual Psychischer Störungen: Textrevision - DSM-IV-TR 2003 Hogrefe, Göttingen, ISBN 3-8017-1660-0
27. S.A. Shankman, P.M. Lewinsohn, D.N. Klein, J.W. Small, J.R. Seeley, and S.E. Altman Subthreshold conditions as precursors for full syndrome disorders: a 15-year longitudinal study of multiple diagnostic classes J. Child Psychol. Psychiatry 50 2009 1485 1494
28. O.J. Storebø, M. Skoog, D. Damm, P.H. Thomsen, E. Simonsen, and C. Gluud Social skills training for Attention Deficit Hyperactivity Disorder (ADHD) in children aged 5-18 years Cochrane Database Syst. Rev. 7 2011 CD008223
29. D.M. Taibi, M.V. Vitiello, S. Barsness, G.W. Elmer, G.D. Anderson, and C.A. Landis A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia Sleep Med. 10 2009 319 328
30. D.R. Thomas 5-ht5A receptors as a therapeutic target Pharmacol. Ther. 111 2006 707 714
31. G. Wake, J. Court, A. Pickering, R. Lewis, R. Wilkins, and E. Perry CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory J. Ethnopharmacol. 69 2000 105 114 (Pubitemid 30016025)
32. G. Ziegler, M. Ploch, A. Miettinen-Baumann, and W. Collet Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia - a randomized, double-blind, comparative clinical study Eur. J. Med. Res. 7 2002 480 486