First identification and quantification of lorcaserin in an herbal slimming dietary supplement

Journal of Pharmaceutical and Biomedical Analysis

Volumn 98, Issue , 2014, Pages 94-99

  Hachem, Rabab ^a   Malet Martino, Myriam ^a   Gilard, Véronique ^a  

^a Université Paul Sabatier Toulouse III   (France)

Author keywords

Adulteration; Lorcaserin; Mass Spectrometry (MS); Nuclear Magnetic Resonance (NMR); Slimming dietary supplements

Indexed keywords

LORCASERIN; BENZAZEPINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHROMATOGRAPHY; DIET SUPPLEMENTATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WEIGHT REDUCTION; ANALYSIS; CHEMISTRY; HERBAL MEDICINE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES;

BENZAZEPINES; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; HERBAL MEDICINE; MAGNETIC RESONANCE SPECTROSCOPY; TANDEM MASS SPECTROMETRY;

EID: 84901951763     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.05.003     Document Type: Article

References (13)

1. Petroczi A., Taylor G., Naughton D.P. Mission impossible? Regulatory and enforcement issues to ensure safety of dietary supplements. Food Chem. Toxicol. 2011, 49:393-402.
2. de Carvalho L.M., Martini M., Moreira A.P., de Lima A.P., Correia D., Falcao T., Garcia S.C., de Bairros A.V., do Nascimento P.C., Bohrer D. Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations and their analytical determination. Forensic Sci. Int. 2011, 204:6-12.
3. 1H-NMR. Food Addit. Contam. Part A 2010, 27:903-916.
4. Ariburnu E., Uludag M.F., Yalcinkaya H., Yesilada E. Comparative determination of sibutramine as an adulterant in natural slimming products by HPLC and HPTLC densitometry. J. Pharm. Biomed. Anal. 2012, 64-65:77-81.
5. Deconinck E., Verlinde K., Courselle P., Beer J.O. A validated Ultra High Pressure Liquid Chromatographic method for the characterisation of confiscated illegal slimming products containing anorexics. J. Pharm. Biomed. Anal. 2012, 59:38-43.
6. Shi Y., Sun C., Gao B., Sun A. Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods. J. Chromatogr. A 2011, 1218:7655-7662.
7. Kim H.J., Lee J.H., Park H.J., Cho S.H., Cho S., Kim W.S. Monitoring of 29 weight-loss compounds in foods and dietary supplements by LC-MS/MS. Food Addit. Contam. Part A 2014, 31:777-783.
8. Fleming J.W., McClendon K.S., Riche D.M. New obesity agents: lorcaserin and phentermine/topiramate. Ann. Pharmacother. 2013, 47:1007-1016.
9. (accessed 28.03.14). http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022529lbl.pdf.
10. (accessed 28.03.14). http://www.deadiversion.usdoj.gov/schedules/.
11. Smith B.M., Smith J.M., Tsai J.H., Schultz J.A., Gilson C.A., Estrada S.A., Chen R.R., Park D.M., Prieto E.B., Gallardo C.S., Sengupta D., Dosa P.I., Covel J.A., Ren A., Webb R.R., Beeley N.R.A., Martin M., Morgan M., Espitia S., Saldana H.R., Bjenning C., Whelan K.T., Grottick A.J., Menzaghi F., Thomsen W.J. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. J. Med. Chem. 2008, 51:305-313.
12. Holzgrabe U. Quantitative NMR spectroscopy in pharmaceutical applications. Progr. NMR Spectrosc. 2010, 57:229-240.
13. Shram M.J., Schoedel K.A., Bartlett C., Shazer R.L., Anderson C.M., Sellers E.M. Evaluation of the abuse potential of Lorcaserin, a serotonin 2C (5-HT2C) receptor agonist, in recreational polydrug users. Clin. Pharmacol. Ther. 2011, 89:683-692.