Remote or extraischemic intracerebral hemorrhage-an uncommon complication of stroke thrombolysis: Results from the safe implementation of treatments in stroke-international stroke thrombolysis register

Stroke

Volumn 45, Issue 6, 2014, Pages 1657-1663

  Mazya, Michael V ^a,b   Ahmed, Niaz ^a,b   Ford, Gary A ^c   Hobohm, Carsten ^d   Mikulik, Robert ^e   Nunes, A Paiva ^f   Wahlgren, Nils ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^f Centro Hospitalar Lisboa Central   (Portugal)

Author keywords

cerebral hemorrhage; cerebral infarction; database; prognosis; thrombolytic therapy

Indexed keywords

ACETYLSALICYLIC ACID; ALTEPLASE; GLUCOSE;

ADULT; AGE; AGED; ARTICLE; BLOOD CLOT LYSIS; BLOOD VESSEL PARAMETERS; BRAIN ARTERY; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; EXTRAISCHEMIC INTRACEREBRAL HEMORRHAGE; FEMALE; FEMININITY; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEART ATRIUM FIBRILLATION; HUMAN; HYPERDENSE CEREBRAL ARTERY SIGN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PARENCHYMAL HEMORRHAGE; PREVALENCE; PRIORITY JOURNAL; REMOTE PARENCHYMAL HEMORRHAGE; RISK FACTOR; SYSTOLIC BLOOD PRESSURE;

CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; DATABASE; PROGNOSIS; THROMBOLYTIC THERAPY;

AGE FACTORS; AGED; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84901941821     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.004923     Document Type: Article

References (21)

1. Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, et al; SITS-MOST investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007;369:275-282
2. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Intracerebral hemorrhage after intravenous t-PA for isch-emic stroke. Stroke. 1997;28:2109-2118.
3. Fiorelli M, Bastianello S, von Kummer R, del Zoppo GJ, Larrue V, Lesaffre E, et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke. 1999;30:2280-2284.
4. Trouillas P, von Kummer R. Classifcation and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke. Stroke. 2006; 37:556-561.
5. Gore JM, Granger CB, Simoons ML, Sloan MA, Weaver WD, White HD, et al. Stroke after thrombolysis. Mortality and functional outcomes in the GUSTO-I trial. Global Use of Strategies to Open Occluded Coronary Arteries. Circulation. 1995;92:2811-2818.
6. Martínez-Hernández E, Martínez-Ramírez S, Delgado-Mederos R, Alcolea D, Marquié M, Marín R, et al. Remote cerebral hema-tomas in patients treated with intravenous rt-PA. J Neurol. 2010; 257:1062-1066.
7. Whiteley WN, Slot KB, Fernandes P, Sandercock P, Wardlaw J. Risk factors for intracranial hemorrhage in acute ischemic stroke patients treated with recombinant tissue plasminogen activator: a systematic review and meta-analysis of 55 studies. Stroke. 2012;43:2904-2909.
8. Mazya M, Egido JA, Ford GA, Lees KR, Mikulik R, Toni D, et al; SITS Investigators. Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracere-bral hemorrhage risk score. Stroke. 2012;43:1524-1531.
9. Wahlgren N, Ahmed N, Davalos A, Hacke W, Millán M, Muir K, et al. Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet. 2008;372:1303-1309.
10. Larrue V, von Kummer R R, Müller A, Bluhmki E. Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke. 2001;32:438-441.
11. Hirohata M, Yoshita M, Ishida C, Ikeda SI, Tamaoka A, Kuzuhara S, et al. Clinical features of non-hypertensive lobar intracerebral hemorrhage related to cerebral amyloid angiopathy. Eur J Neurol. 2010;17:823-829.
12. Attems J, Lauda F, Jellinger KA. Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage. J Neurol. 2008;255:70-76.
13. Oide T, Takahashi H, Yutani C, Ishihara T, Ikeda S. Relationship between lobar intracerebral hemorrhage and leukoencephalopathy associated with cerebral amyloid angiopathy: clinicopathological study of 64 Japanese patients. Amyloid. 2003;10:136-143.
14. Petridis AK, Barth H, Buhl R, Hugo HH, Mehdorn HM. Outcome of cerebral amyloid angiopathic brain haemorrhage. Acta Neurochir (Wien). 2008;150:889-895.
15. Biff A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol. 2011;7:1-9.
16. Gaillard N, Schmidt C, Costalat V, Bousquet JP, Heroum C, Milhaud D, et al. Hemorrhagic risk of recent silent cerebral infarct on pre-thrombolysis MR imaging in acute stroke. AJNR Am J Neuroradiol. 2012;33:227-231.
17. Menon BK, Saver JL, Prabhakaran S, Reeves M, Liang L, Olson DM, et al. Risk score for intracranial hemorrhage in patients with acute isch-emic stroke treated with intravenous tissue-type plasminogen activator. Stroke. 2012;43:2293-2299.
18. Messé SR, Pervez MA, Smith EE, Siddique KA, Hellkamp AS, Saver JL, et al. Lipid profle, lipid-lowering medications, and intracere-bral hemorrhage after tPA in get with the guidelines-stroke. Stroke. 2013;44:1354-1359.
19. Strbian D, Sairanen T, Meretoja A, Pitkäniemi J, Putaala J, Salonen O, et al; Helsinki Stroke Thrombolysis Registry Group. Patient outcomes from symptomatic intracerebral hemorrhage after stroke thrombolysis. Neurology. 2011;77:341-348.
20. McCarron MO, Nicoll JA. Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage. Lancet Neurol. 2004;3:484-492.
21. Charidimou A, Krishnan A, Werring DJ, Rolf Jäger H. Cerebral micro-bleeds: a guide to detection and clinical relevance in different disease settings. Neuroradiology. 2013;55:655-674.