Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 6, 2014, Pages 1070-1075

  Gao, Chao ^a   Du, Hanjian ^a   Hua, Ya ^a   Keep, Richard F ^a   Strahle, Jennifer ^a   Xi, Guohua ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

deferoxamine; hydrocephalus; intracerebral hemorrhage; iron; red blood cell

Indexed keywords

DEFEROXAMINE; FERRITIN; HEME OXYGENASE 1; HEMOGLOBIN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN HISTOLOGY; BRAIN SIZE; CELL DAMAGE; CONTROLLED STUDY; EPENDYMA CELL; ERYTHROCYTE CONCENTRATE; HEMOLYSIS; HYDROCEPHALUS; IRON CHELATION; LATERAL BRAIN VENTRICLE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CEREBRAL HEMORRHAGE; DEFEROXAMINE; ERYTHROCYTES; FERRITINS; HEME OXYGENASE-1; HEMOLYSIS; HYDROCEPHALUS; IRON; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIDEROPHORES;

EID: 84901856173     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.56     Document Type: Article

References (32)

1. Bhattathiri PS, Gregson B, Prasad KS, Mendelow AD. Intraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the stich trial. Acta Neurochir Suppl 2006; 96: 65-68.
2. Hanley DF. Intraventricular hemorrhage: severity factor and treatment target in spontaneous intracerebral hemorrhage. Stroke 2009; 40: 1533-1538.
3. Rosen D, Macdonald R, Huo D, Goldenberg F, Novakovic R, Frank J et al. Intraventricular hemorrhage from ruptured aneurysm: clinical characteristics, complications, and outcomes in a large, prospective, multicenter study population. J Neurosurg 2007; 107: 261-265. (Pubitemid 47219367)
4. Gao F, Liu F, Chen Z, Hua Y, Keep RF, Xi G. Hydrocephalus after intraventricular hemorrhage: the role of thrombin. J Cereb Blood Flow Metab 2014; 34: 489-494.
5. Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A. Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatr Res 2001; 49: 208-212. (Pubitemid 32120148)
6. Suzuki H, Muramatsu M, Tanaka K, Fujiwara H, Kojima T, Taki W. Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage. J Neurol 2006; 253: 1170-1176. (Pubitemid 44511474)
7. Rypens F, Avni EF, Dussaussois L, David P, Vermeylen D, Van Bogaert P et al. Hyperechoic thickened ependyma: sonographic demonstration and significance in neonates. Pediatr Radiol 1994; 24: 550-553.
8. Massicotte EM, Del Bigio MR. Human arachnoid villi response to subarachnoid hemorrhage: possible relationship to chronic hydrocephalus. J Neurosurg 1999; 91: 80-84.
9. Fukumizu M, Takashima S, Becker LE. Glial reaction in periventricular areas of the brainstem in fetal and neonatal posthemorrhagic hydrocephalus and congenital hydrocephalus. Brain Dev 1996; 18: 40-45. (Pubitemid 26061223)
10. Chen Z, Gao C, Hua Y, Keep RF, Muraszko K, Xi G. Role of iron in brain injury after intraventricular hemorrhage. Stroke 2011; 42: 465-470.
11. Okubo S, Strahle J, Keep RF, Hua Y, Xi G. Subarachnoid hemorrhage-induced hydrocephalus in rats. Stroke 2013; 44: 547-550.
12. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg 1998; 89: 991-996. (Pubitemid 28544054)
13. Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke 2009; 40: 1858-1863.
14. Hu S, Xi G, Jin H, He Y, Keep RF, Hua Y. Thrombin-induced autophagy: a potential role in intracerebral hemorrhage. Brain Res 2011; 1424: 60-66.
15. He Y, Karabiyikoglu M, Hua Y, Keep RF, Xi G. Ischemic preconditioning attenuates brain edema after experimental intracerebral hemorrhage. Transl Stroke Res 2012; 3: 180-187.
16. Lodhia KR, Shakui P, Keep RF. Hydrocephalus in a rat model of intraventricular hemorrhage. Acta Neurochir Suppl 2006; 96: 207-211.
17. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral hemorrhage. Lancet Neurol 2006; 5: 53-63. (Pubitemid 41790696)
18. Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol 2012; 11: 720-731.
19. Nakamura T, Xi G, Park JW, Hua Y, Hoff JT, Keep RF. Holo-transferrin and thrombin can interact to cause brain damage. Stroke 2005; 36: 348-352. (Pubitemid 40170821)
20. Erikson KM, Pinero DJ, Connor JR, Beard JL. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 1997; 127: 2030-2038. (Pubitemid 27424443)
21. Huang F, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 2002; 96: 287-293. (Pubitemid 34230243)
22. Gram M, Sveinsdottir S, Ruscher K, Hansson SR, Cinthio M, Akerstrom B et al. Hemoglobin induces inflammation after preterm intraventricular hemorrhage by methemoglobin formation. J Neuroinflammation 2013; 10: 100.
23. Umbreit J. Methemoglobin-it's not just blue: a concise review. Am J Hematol 2007; 82: 134-144. (Pubitemid 46155276)
24. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res 2005; 1039: 30-36. (Pubitemid 40386824)
25. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF. Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 2003; 23: 629-652. (Pubitemid 36713668)
26. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 2003; 34: 2964-2969. (Pubitemid 37517778)
27. Gong Y, Tian H, Xi G, Keep R, Hoff J, Hua Y. Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury. Acta Neurochirur Suppl 2006; 96: 232-236.
28. Hatakeyama T, Okauchi M, Hua Y, Keep RF, Xi G. Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats. Transl Stroke Res 2013; 4: 546-553.
29. Guo F, Hua Y, Wang J, Keep RF, Xi G. Inhibition of carbonic anhydrase reduces brain injury after intracerebral hemorrhage. Transl Stroke Res 2012; 3: 130-137.
30. Baas D, Meiniel A, Benadiba C, Bonnafe E, Meiniel O, Reith W et al. A deficiency in rfx3 causes hydrocephalus associated with abnormal differentiation of ependy-mal cells. Eur J Neurosci 2006; 24: 1020-1030. (Pubitemid 44268133)
31. Lechtreck KF, Delmotte P, Robinson ML, Sanderson MJ, Witman GB. Mutations in hydin impair ciliary motility in mice. J Cell Biol 2008; 180: 633-643. (Pubitemid 351240709)
32. Gavino C, Richard S. Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus. Mol Cell Neurosci 2011; 47: 100-107.