The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4

Experimental Gerontology

Volumn 56, Issue , 2014, Pages 45-52

  Goy, Christine ^b   Czypiorski, Philip ^b   Altschmied, Joachim ^b   Jakob, Sascha ^b   Rabanter, Lothar L ^b   Brewer, Alison C ^c   Ale Agha, Niloofar ^b   Dyballa Rukes, Nadine ^b   Shah, Ajay M ^c   Haendeler, Judith ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cathepsin D; Endothelial cells; Imbalanced redox homeostasis; NADPH oxidase 4; Senescence; Thioredoxin 1

Indexed keywords

BETA GALACTOSIDASE; CATHEPSIN D; HYDROGEN PEROXIDE; PEPSTATIN; PROTEIN P21; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; THIOREDOXIN 1; CTSD PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN; OXIDIZING AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOREDOXIN; TXN PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REDOX STRESS; SENESCENCE; UPREGULATION; ANIMAL; C57BL MOUSE; CELL AGING; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS MUSCULUS;

ANIMALS; CATHEPSIN D; CELL AGING; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; MICE, INBRED C57BL; MICE, TRANSGENIC; NADPH OXIDASE; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; THIOREDOXINS; TRANSFECTION;

EID: 84901855572     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.03.005     Document Type: Article

References (30)

1. Abramoff M.D., Magelhaes P.J., Ram S.J. Image processing with ImageJ. Biophoton. Int. 2004, 11:36-42.
2. Ago T., Kuroda J., Pain J., et al. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ. Res. 2010, 106:1253-1264.
3. Altschmied J., Haendeler J. Thioredoxin-1 and endothelial cell aging: role in cardiovascular diseases. Antioxid. Redox Signal. 2009, 11:1733-1740.
4. Anilkumar N., Weber R., Zhang M., et al. Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1347-1354.
5. Babior B.M., Kipnes R.S., Curnutte J.T. Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J. Clin. Invest. 1973, 52:741-744.
6. Barnett A., Brewer G.J. Autophagy in aging and Alzheimer's disease: pathologic or protective?. J. Alzheimers Dis. 2011, 25:385-394.
7. Bedard K., Krause K.H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 2007, 87:245-313.
8. Block K., Gorin Y., Abboud H.E. Subcellular localization of Nox4 and regulation in diabetes. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14385-14390.
9. Cataldo A.M., Barnett J.L., Berman S.A., et al. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 1995, 14:671-680.
10. Fierro-Gonzalez J.C., Gonzalez-Barrios M., Miranda-Vizuete A., et al. The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 2011, 406:478-482.
11. Follo C., Ozzano M., Mugoni V., et al. Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish. PLoS One 2011, 6:e21908.
12. Haendeler J. Thioredoxin-1 and posttranslational modifications. Antioxid. Redox Signal. 2006, 8:1723-1728.
13. Haendeler J., Hoffmann J., Tischler V., et al. Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nat. Cell Biol. 2002, 4:743-749.
14. Haendeler J., Hoffmann J., Diehl J.F., et al. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ. Res. 2004, 94:768-775.
15. Haendeler J., Tischler V., Hoffmann J., et al. Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression. FEBS Lett. 2004, 577:427-433.
16. Haendeler J., Popp R., Goy C., et al. Cathepsin D and H2O2 stimulate degradation of thioredoxin-1: implication for endothelial cell apoptosis. J. Biol. Chem. 2005, 280:42945-42951.
17. Haendeler J., Drose S., Buchner N., et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler. Thromb. Vasc. Biol. 2009, 29:929-935.
18. Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid. Redox Signal. 2000, 2:811-820.
19. Koziel R., Pircher H., Kratochwil M., et al. Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4. Biochem. J. 2013, 452:231-239.
20. Krause K.H. Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidases. Exp. Gerontol. 2007, 42:256-262.
21. Lener B., Koziel R., Pircher H., et al. The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. Biochem. J. 2009, 423:363-374.
22. Lopez-Otin C., Blasco M.A., Partridge L., et al. The hallmarks of aging. Cell 2013, 153:1194-1217.
23. Matsui M., Oshima M., Oshima H., et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev. Biol. 1996, 178:179-185.
24. Moffat J., Grueneberg D.A., Yang X., et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 2006, 124:1283-1298.
25. North B.J., Sinclair D.A. The intersection between aging and cardiovascular disease. Circ. Res. 2012, 110:1097-1108.
26. Ray R., Murdoch C.E., Wang M., et al. Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler. Thromb. Vasc. Biol. 2011, 31:1368-1376.
27. Ronchi J.A., Figueira T.R., Ravagnani F.G., et al. A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities. Free Radic. Biol. Med. 2013, 63:446-456.
28. Strait J.B., Lakatta E.G. Aging-associated cardiovascular changes and their relationship to heart failure. Heart Fail. Clin. 2012, 8:143-164.
29. Yoshida T., Nakamura H., Masutani H., et al. The involvement of thioredoxin and thioredoxin binding protein-2 on cellular proliferation and aging process. Ann. N. Y. Acad. Sci. 2005, 1055:1-12.
30. Zschauer T.C., Matsushima S., Altschmied J., et al. Interacting with thioredoxin-1-disease or no disease?. Antioxid. Redox Signal. 2013, 18:1053-1062.