메뉴 건너뛰기




Volumn 28, Issue 6, 2014, Pages 2455-2465

HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells

Author keywords

Cartilage; Hypoxia; Intervertebral disc

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SYNDECAN 4; TRANSCRIPTION FACTOR SOX9;

EID: 84901854005     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-243741     Document Type: Article
Times cited : (35)

References (43)
  • 1
    • 28844502298 scopus 로고    scopus 로고
    • Vertebral endplate architecture and vascularization: Application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat
    • DOI 10.1097/01.brs.0000187877.30149.83
    • Gruber, H. E., Ashraf, N., Kilburn, J., Williams, C., Norton, H. J., Gordon, B. E., and Hanley, E. N. Jr. (2005) Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat. Spine 30, 2593-2600 (Pubitemid 41780368)
    • (2005) Spine , vol.30 , Issue.23 , pp. 2593-2600
    • Gruber, H.E.1    Ashraf, N.2    Kilburn, J.3    Williams, C.4    Norton, H.J.5    Gordon, B.E.6    Hanley Jr., E.N.7
  • 2
    • 0014655990 scopus 로고
    • The human intervertebral disc. A microangio-graphical study on its vascular supply at various ages
    • Hassler, O. (1969) The human intervertebral disc. A microangio-graphical study on its vascular supply at various ages. Acta Orthop. Scand. 40, 765-772
    • (1969) Acta Orthop. Scand. , vol.40 , pp. 765-772
    • Hassler, O.1
  • 3
    • 0027466510 scopus 로고
    • Lymph and blood supply of the human intervertebral disc: Cadaver study of correlations to discitis
    • Rudert, M., and Tillmann, B. (1993) Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis. Acta Orthop. Scand. 64, 37-40 (Pubitemid 23092299)
    • (1993) Acta Orthopaedica Scandinavica , vol.64 , Issue.1 , pp. 37-40
    • Rudert, M.1    Tillmann, B.2
  • 4
    • 0031908754 scopus 로고    scopus 로고
    • Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain
    • Bartels, E. M., Fairbank, J. C., Winlove, C. P., and Urban, J. P. (1998) Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 23, 1-7
    • (1998) Spine , vol.23 , pp. 1-7
    • Bartels, E.M.1    Fairbank, J.C.2    Winlove, C.P.3    Urban, J.P.4
  • 5
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G. L., Roth, P. H., Fang, H. M., and Wang, G. L. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763 (Pubitemid 24293585)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.38 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.-M.3    Wang, G.L.4
  • 6
    • 0035989142 scopus 로고    scopus 로고
    • Phenotypic characteristics of the nucleus pulposus: Expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2
    • DOI 10.1007/s00441-002-0563-6
    • Rajpurohit, R., Risbud, M. V., Ducheyne, P., Vresilovic, E. J., and Shapiro, I. M. (2002) Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res. 308, 401-407 (Pubitemid 34666966)
    • (2002) Cell and Tissue Research , vol.308 , Issue.3 , pp. 401-407
    • Rajpurohit, R.1    Risbud, M.V.2    Ducheyne, P.3    Vresilovic, E.J.4    Shapiro, I.M.5
  • 7
    • 33646010313 scopus 로고    scopus 로고
    • Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment
    • Risbud, M. V., Guttapalli, A., Stokes, D. G., Hawkins, D., Danielson, K. G., Schaer, T. P., Albert, T. J., and Shapiro, I. M. (2006) Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J. Cell. Biochem. 98, 152-159
    • (2006) J. Cell. Biochem. , vol.98 , pp. 152-159
    • Risbud, M.V.1    Guttapalli, A.2    Stokes, D.G.3    Hawkins, D.4    Danielson, K.G.5    Schaer, T.P.6    Albert, T.J.7    Shapiro, I.M.8
  • 8
    • 34547763695 scopus 로고    scopus 로고
    • Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
    • DOI 10.1152/ajpcell.00538.2006
    • Agrawal, A., Guttapalli, A., Narayan, S., Albert, T. J., Shapiro, I. M., and Risbud, M. V. (2007) Normoxic stabilization of HIF-1α drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am. J. Physiol. Cell Physiol. 293, C621-C631 (Pubitemid 47235198)
    • (2007) American Journal of Physiology - Cell Physiology , vol.293 , Issue.2
    • Agrawal, A.1    Guttapalli, A.2    Narayan, S.3    Albert, T.J.4    Shapiro, I.M.5    Risbud, M.V.6
  • 9
    • 57349102342 scopus 로고    scopus 로고
    • Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc
    • Agrawal, A., Gajghate, S., Smith, H., Anderson, D. G., Albert, T. J., Shapiro, I. M., and Risbud, M. V. (2008) Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis Rheum. 58, 3798-3808
    • (2008) Arthritis Rheum. , vol.58 , pp. 3798-3808
    • Agrawal, A.1    Gajghate, S.2    Smith, H.3    Anderson, D.G.4    Albert, T.J.5    Shapiro, I.M.6    Risbud, M.V.7
  • 11
    • 84877152316 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity
    • Tran, C. M., Fujita, N., Huang, B. L., Ong, J. R., Lyons, K. M., Shapiro, I. M., and Risbud, M. V. (2013) Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity. J. Biol. Chem. 288, 12654-12666
    • (2013) J. Biol. Chem. , vol.288 , pp. 12654-12666
    • Tran, C.M.1    Fujita, N.2    Huang, B.L.3    Ong, J.R.4    Lyons, K.M.5    Shapiro, I.M.6    Risbud, M.V.7
  • 12
    • 84856160786 scopus 로고    scopus 로고
    • HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
    • Fujita, N., Chiba, K., Shapiro, I. M., and Risbud, M. V. (2012) HIF-1α and HIF-2α degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. J. Bone Miner. Res. 27, 401-412
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 401-412
    • Fujita, N.1    Chiba, K.2    Shapiro, I.M.3    Risbud, M.V.4
  • 13
    • 84860864145 scopus 로고    scopus 로고
    • Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: Distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia
    • Fujita, N., Markova, D., Anderson, D. G., Chiba, K., Toyama, Y., Shapiro, I. M., and Risbud, M. V. (2012) Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia. J. Biol. Chem. 287, 16975-16986
    • (2012) J. Biol. Chem. , vol.287 , pp. 16975-16986
    • Fujita, N.1    Markova, D.2    Anderson, D.G.3    Chiba, K.4    Toyama, Y.5    Shapiro, I.M.6    Risbud, M.V.7
  • 14
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxial
    • Sowter, H. M., Raval, R. R., Moore, J. W., Ratcliffe, P. J., and Harris, A. L. (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1α versus Hif-2α in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130-6134 (Pubitemid 37255150)
    • (2003) Cancer Research , vol.63 , Issue.19 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.2    Moore, J.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 15
    • 16244380777 scopus 로고    scopus 로고
    • Syndecans: New kids on the signaling block
    • DOI 10.1161/01.RES.0000159708.71142.c8
    • Tkachenko, E., Rhodes, J. M., and Simons, M. (2005) Syndecans: new kids on the signaling block. Circ. Res. 96, 488-500 (Pubitemid 40463457)
    • (2005) Circulation Research , vol.96 , Issue.5 , pp. 488-500
    • Tkachenko, E.1    Rhodes, J.M.2    Simons, M.3
  • 16
    • 84455173121 scopus 로고    scopus 로고
    • Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions
    • Chang, S. C., Mulloy, B., Magee, A. I., and Couchman, J. R. (2011) Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions. J. Biol. Chem. 286, 44391-44402
    • (2011) J. Biol. Chem. , vol.286 , pp. 44391-44402
    • Chang, S.C.1    Mulloy, B.2    Magee, A.I.3    Couchman, J.R.4
  • 18
    • 81155132248 scopus 로고    scopus 로고
    • TNF-α and IL-1α promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc
    • Wang, J., Markova, D., Anderson, D. G., Zheng, Z., Shapiro, I. M., and Risbud, M. V. (2011) TNF-α and IL-1α promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J. Biol. Chem. 286, 39738-39749
    • (2011) J. Biol. Chem. , vol.286 , pp. 39738-39749
    • Wang, J.1    Markova, D.2    Anderson, D.G.3    Zheng, Z.4    Shapiro, I.M.5    Risbud, M.V.6
  • 21
    • 33144482986 scopus 로고    scopus 로고
    • Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-κB-dependent manner
    • DOI 10.1093/glycob/cwj061
    • Smith, M. F., Jr., Novotny, J., Carl, V. S., and Comeau, L. D. (2006) Helicobacter pylori and Toll-like receptor agonists induce syndecan-4 expression in an NF-κB-dependent manner. Glycobiology 16, 221-229 (Pubitemid 43264688)
    • (2006) Glycobiology , vol.16 , Issue.3 , pp. 221-229
    • Smith Jr., M.F.1    Novotny, J.2    Carl, V.S.3    Comeau, L.D.4
  • 22
    • 49449100695 scopus 로고    scopus 로고
    • L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    • Han, Y., and Lefebvre, V. (2008) L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol. Cell. Biol. 28, 4999-5013
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4999-5013
    • Han, Y.1    Lefebvre, V.2
  • 24
    • 77950565914 scopus 로고    scopus 로고
    • Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway
    • Fu, J., and Taubman, M. B. (2010) Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway. J. Biol. Chem. 285, 8927-8935
    • (2010) J. Biol. Chem. , vol.285 , pp. 8927-8935
    • Fu, J.1    Taubman, M.B.2
  • 25
    • 77956604234 scopus 로고    scopus 로고
    • HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells
    • Johansen, J. L., Sager, T. N., Lotharius, J., Witten, L., Mørk, A., Egebjerg, J., and Thirstrup, K. (2010) HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells. J. Neurochem. 115, 209-219
    • (2010) J. Neurochem. , vol.115 , pp. 209-219
    • Johansen, J.L.1    Sager, T.N.2    Lotharius, J.3    Witten, L.4    Mørk, A.5    Egebjerg, J.6    Thirstrup, K.7
  • 27
    • 70450263243 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity
    • Sun, Q., Zhou, H., Binmadi, N. O., and Basile, J. R. (2009) Hypoxia-inducible factor-1-mediated regulation of semaphorin 4D affects tumor growth and vascularity. J. Biol. Chem. 284, 32066-32074
    • (2009) J. Biol. Chem. , vol.284 , pp. 32066-32074
    • Sun, Q.1    Zhou, H.2    Binmadi, N.O.3    Basile, J.R.4
  • 28
    • 33845604971 scopus 로고    scopus 로고
    • HIF-dependent induction of adenosine A2B receptor in hypoxia
    • DOI 10.1096/fj.06-6419com
    • Kong, T., Westerman, K. A., Faigle, M., Eltzschig, H. K., and Colgan, S. P. (2006) HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J. 20, 2242-2250 (Pubitemid 44953854)
    • (2006) FASEB Journal , vol.20 , Issue.13 , pp. 2242-2250
    • Kong, T.1    Westerman, K.A.2    Faigle, M.3    Eltzschig, H.K.4    Colgan, S.P.5
  • 29
    • 84869203441 scopus 로고    scopus 로고
    • Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling
    • Fujita, N., Gogate, S. S., Chiba, K., Toyama, Y., Shapiro, I. M., and Risbud, M. V. (2012) Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling. J. Biol. Chem. 287, 39942-39953
    • (2012) J. Biol. Chem. , vol.287 , pp. 39942-39953
    • Fujita, N.1    Gogate, S.S.2    Chiba, K.3    Toyama, Y.4    Shapiro, I.M.5    Risbud, M.V.6
  • 30
    • 80051977344 scopus 로고    scopus 로고
    • Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxiainducible factor-1α transcription factor and its target genes in mice
    • Adluri, R. S., Thirunavukkarasu, M., Dunna, N. R., Zhan, L., Oriowo, B., Takeda, K., Sanchez, J. A., Otani, H., Maulik, G., Fong, G. H., Maulik, N. (2011) Disruption of hypoxia-inducible transcription factor-prolyl hydroxylase domain-1 (PHD-1-/-) attenuates ex vivo myocardial ischemia/reperfusion injury through hypoxiainducible factor-1α transcription factor and its target genes in mice. Antioxid. Redox Signal. 15, 1789-1797
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 1789-1797
    • Adluri, R.S.1    Thirunavukkarasu, M.2    Dunna, N.R.3    Zhan, L.4    Oriowo, B.5    Takeda, K.6    Sanchez, J.A.7    Otani, H.8    Maulik, G.9    Fong, G.H.10    Maulik, N.11
  • 32
    • 75149150805 scopus 로고    scopus 로고
    • Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity
    • Xue, J., Li, X., Jiao, S., Wei, Y., Wu, G., and Fang, J. (2010) Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKβ independent of hydroxylase activity. Gastroenterology 138, 606-615
    • (2010) Gastroenterology , vol.138 , pp. 606-615
    • Xue, J.1    Li, X.2    Jiao, S.3    Wei, Y.4    Wu, G.5    Fang, J.6
  • 33
    • 84876304658 scopus 로고    scopus 로고
    • Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: A mechanism likely deranged in hereditary multiple exostoses
    • Huegel, J., Mundy, C., Sgariglia, F., Nygren, P., Billings, P. C., Yamaguchi, Y., Koyama, E., and Pacifici, M. (2013) Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in hereditary multiple exostoses. Dev. Biol. 377, 100-112
    • (2013) Dev. Biol. , vol.377 , pp. 100-112
    • Huegel, J.1    Mundy, C.2    Sgariglia, F.3    Nygren, P.4    Billings, P.C.5    Yamaguchi, Y.6    Koyama, E.7    Pacifici, M.8
  • 34
    • 0042975394 scopus 로고    scopus 로고
    • The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro
    • DOI 10.1097/01.BRS.0000083204.44190.34
    • Tim, Y. S., Kim, S. K., Li, J., Soo Park, J., Akamaru, T., Elmer, W. A., and Hutton, W. C. (2003) The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine 28, 1773-1780 (Pubitemid 37012751)
    • (2003) Spine , vol.28 , Issue.16 , pp. 1773-1780
    • Yoon, S.T.1    Kim, K.S.2    Li, J.3    Park, J.S.4    Akamaru, T.5    Elmer, W.A.6    Hutton, W.C.7
  • 36
    • 73949092833 scopus 로고    scopus 로고
    • A study on the interactions between heparan sulfate proteoglycans and Wnt proteins
    • Fuerer, C., Habib, S. J., and Nusse, R. (2010) A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev. Dyn. 239, 184-190
    • (2010) Dev. Dyn. , vol.239 , pp. 184-190
    • Fuerer, C.1    Habib, S.J.2    Nusse, R.3
  • 38
    • 84860465584 scopus 로고    scopus 로고
    • Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc
    • Dahia, C. L., Mahoney, E., and Wylie, C. (2012) Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 7, e35944
    • (2012) PLoS One , vol.7
    • Dahia, C.L.1    Mahoney, E.2    Wylie, C.3
  • 39
    • 84874651214 scopus 로고    scopus 로고
    • Degenerative disc disease: Altered Wnt signalling in intervertebral disc degeneration
    • Cully, M. (2013) Degenerative disc disease: Altered Wnt signalling in intervertebral disc degeneration. Nat. Rev. Rheumatol. 9, 136
    • (2013) Nat. Rev. Rheumatol. , vol.9 , pp. 136
    • Cully, M.1
  • 40
    • 18244364365 scopus 로고    scopus 로고
    • Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal
    • DOI 10.1097/01.brs.0000159096.11248.6d
    • Risbud, M. V., Fertala, J., Vresilovic, E. J., Albert, T. J., and Shapiro, I. M. (2005) Nucleus pulposus cells upregulate PI3K/ Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. Spine 30, 882-889 (Pubitemid 40632532)
    • (2005) Spine , vol.30 , Issue.8 , pp. 882-889
    • Risbud, M.V.1    Fertala, J.2    Vresilovic, E.J.3    Albert, T.J.4    Shapiro, I.M.5
  • 41
    • 23844493183 scopus 로고    scopus 로고
    • Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9
    • DOI 10.1016/j.bone.2005.04.040, PII S8756328205002085
    • Robins, J. C., Akeno, N., Mukherjee, A., Dalal, R. R., Aronow, B. J., Koopman, P., and Clemens, T. L. (2005) Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone 37, 313-322 (Pubitemid 41160490)
    • (2005) Bone , vol.37 , Issue.3 , pp. 313-322
    • Robins, J.C.1    Akeno, N.2    Mukherjee, A.3    Dalal, R.R.4    Aronow, B.J.5    Koopman, P.6    Clemens, T.L.7
  • 42
    • 36549088609 scopus 로고    scopus 로고
    • HIF1α regulation of Sox9 in necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
    • DOI 10.1242/dev.008441
    • Amarilio, R., Viukov, S. V., Sharir, A., Eshkar-Oren, I., Johnson, R. S., and Zelzer, E. (2007) HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 134, 3917-3928 (Pubitemid 350187350)
    • (2007) Development , vol.134 , Issue.21 , pp. 3917-3928
    • Amarilio, R.1    Viukov, S.V.2    Sharir, A.3    Eshkar-Oren, I.4    Johnson, R.S.5    Zelzer, E.6
  • 43
    • 35348852177 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype
    • Lafont, J. E., Talma, S., and Murphy, C. L. (2007) Hypoxia-inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype. Arthritis Rheum. 56, 3297-3306
    • (2007) Arthritis Rheum. , vol.56 , pp. 3297-3306
    • Lafont, J.E.1    Talma, S.2    Murphy, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.